Utility of T2-weighted MRI and contrast-enhanced MRA in locating the fistula level of spinal arteriovenous fistula.

Objective: To investigate the value of routine T2-weighted magnetic resonance imaging (MRI) and contrast-enhanced magnetic resonance angiography (CE-MRA) sequences in locating the fistula level of spinal arteriovenous fistula (SAVF).

Methods: Retrospectively analyzed the radiological findings of patients with SAVF diagnosed by surgery from May 2018 to September 2024. All patients completed spinal CE-MRA and routine T2-weighted MRI.

Unveiling multiscale spatiotemporal dynamics of volatility in high-frequency financial markets.

This study explores the intricate dynamics of volatility within high-frequency financial markets, focusing on 225 of Chinese listed companies from 2016 to 2023. Utilizing 5-minute high-frequency data, we analyze the realized volatility of individual stocks across six distinct time scales: 5-minute, 10-minute, 30-minute, 1-hour, 2-hour, and 4-hour intervals. Our investigation reveals a consistent power law decay in the auto-correlation function of realized volatility across all time scales.

Molecular epidemiology and antimicrobial resistance of Vibrio parahaemolyticus isolates from the Pearl River Delta region, China.

The Pearl River Delta (PRD) region in southern China is a densely populated area and a hotspot for Vibrio parahaemolyticus infections. However, systematic research on this pathogen, particularly comparing clinical and environmental strains, remains limited. This study analyzed the molecular epidemiology and antimicrobial resistance of 200 V.

Urinary concentrations of eighteen environmental phenols and the associations with feeding pattern in infants in the first 6 months of life.

Environmental phenols are a group of typical endocrine disruptors, and widely detectable in human breast milk and infant formulas. However, exposures data are scarce in early infancy, a particularly sensitive period to environmental pollutants exposures. We aimed to prospectively assess urinary concentrations of eighteen environmental phenols in infants from birth to 6 months of age and their associations with feeding patterns (breastfeeding, formula and mixed-feeding).

Gestational diabetes mellitus and linear growth in early childhood.

Introduction: Gestational diabetes mellitus (GDM) is a common pregnancy complication with potential short- and long-term adverse consequences for both mothers and fetuses. It is unclear whether GDM affects linear growth in the offspring; research data are limited and inconsistent.

Methods: In a prospective birth cohort in Shanghai (n=2055 children; 369 born to mothers with GDM).

Artesunate protects against a mouse model of cerulein and lipopolysaccharide‑induced acute pancreatitis by inhibiting TLR4‑dependent autophagy.

Severe acute pancreatitis (SAP) is a severe clinical condition associated with high rates of morbidity and mortality. Multiple organ dysfunction syndrome that follows systemic inflammatory response syndrome is the leading cause of SAP‑related death. Since the inflammatory mechanism of SAP remains unclear, there is currently a lack of effective drugs available for its treatment.

A Sensitivity and Consistency Comparison Between Next-Generation Sequencing and Sanger Sequencing in HIV-1 Pretreatment Drug Resistance Testing.

Next-generation sequencing (NGS) for HIV drug resistance (DR) testing has an increasing number of applications for the detection of low-abundance drug-resistant variants (LA-DRVs) in regard to its features as a quasi-species. However, there is less information on its detection performance in DR detection with NGS. To determine the feasibility of using NGS technology in LA-DRV detection for HIV-1 pretreatment drug resistance, 80 HIV-infected individuals who had never undergone antiretroviral therapy were subjected to both NGS and Sanger sequencing (SS) in HIV-1 drug resistance testing.

Temperature-driven cotton verticillium wilt: a beta model for risk assessment from laboratory insights to climate scenarios.

Background: Verticillium wilt is a critical disease affecting cotton in the Xinjiang province, a region producing 90% cotton in China. Defining the specific temperature thresholds for disease prevalence is essential but has remained unclear.

Results: This study aimed to establish a model to quantify the relationship between temperature and cotton verticillium wilt disease risk.

Branched-chain amino acid catabolism promotes M2 macrophage polarization.

Introduction: During an immune response, macrophages undergo systematic metabolic rewiring tailored to support their functions. Branched-chain amino acid (BCAA) metabolism has been reported to modulate macrophage function; however, its role in macrophage alternative activation remain unclear. We aimed to investigate the role of BCAA metabolism in macrophage alternative activation.

Brain structures as potential mediators of the causal effect of COVID 19 on migraine risk.

Migraine is a common neurological disorder observed after coronavirus disease 2019 (COVID 19) infection. However, the intricate relationship between COVID 19 and migraine, particularly the potential mediating role of brain imaging-derived phenotypes (BIPs), remains unclear. This study used linkage disequilibrium score regression (LDSC), a bidirectional two-sample Mendelian randomization (MR) approach, and two-step MR analysis to investigate potential causal links.

Aberrant dynamic functional network connectivity in patients with diffuse axonal injury.

Diffuse axonal injury (DAI) results in aberrant functional connectivity and is significantly linked to cognitive impairment. Nevertheless, the network mechanisms influencing neurocognitive function following DAI remain unclear. This study aimed to examine the characteristics of static and dynamic functional network connectivity (FNC) in patients with DAI.

NIR-intervened thermally accelerated urease-propelled MOF nanosubmarine for antibiotic-free antibacterial inhibition via single-wavelength synergistic PDT/PTT.

The increasing resistance of bacteria to antibiotics poses a serious threat to global human health. Herein, we have developed a thermal-accelerated biomacromolecular urease-driven MOF-based nanomotor (ZIF-8@PDA@ICG@Ur) mediated via NIR-intervened antimicrobial therapy. In this system, we have attempted for the first time to introduce an easy-to-operate light combination therapy strategy (only one light source is required) into an enzyme-driven MOF motor system to achieve antibiotic-free antibacterial therapy.

Radiofrequency balloon ablation: 1-year outcomes of the AURORA study.

Background: A novel irrigated radiofrequency balloon (RFB) for pulmonary vein isolation (PVI) integrated into a 3D mapping platform was recently launched.

Methods: Patients undergoing a first atrial fibrillation (AF) ablation at two German high-volume EP centers were included into the prospective AURORA registry. All patients underwent clinical follow-up (FU) at 90, 180, and 360 days following ablation including 48-h Holter ECGs.

Intravascular enhancement sign at 3D T1-weighted turbo spin echo sequence is associated with cerebral atherosclerotic stenosis.

Objective: Intravascular enhancement sign (IVES) at three-dimensional T1-weighted turbo spin echo (3D T1W TSE) sequence may be a simple hemodynamic maker. This study aims to investigate the association between IVES and features of intracranial atherosclerotic stenosis (ICAS).

Method: Retrospective analysis of clinical and imaging data of patients who underwent high resolution-vessel wall imaging (HR-VWI) examination from May 2021 to May 2023.

Chromosome-level genome of Osmia excavata (Hymenoptera: Megachilidae) provides insights into low-temperature tolerance of Osmia pollinator.

The solitary bee Osmia excavata (Hymenoptera: Megachilidae) is a key pollinator managed on a large scale. It has been widely used for commercial pollination of fruit trees, vegetables, and other crops with high efficiency in increasing the crop seeding rate, yield, and seed quality in Northern hemisphere. Here, a high-quality chromosome-level genome of O.

Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice.

Background: In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells within the lesion core, where the fibrotic scar is predominantly orchestrated by platelet-derived growth factor receptor beta (PDGFRβ) fibroblasts. Galectin-3, a carbohydrate-binding protein of the lectin family, is notably expressed by infiltrating hematogenous macrophages and mediates cell-cell interactions. Although Galectin-3 has been shown to contribute to the endocytic internalization of PDGFRβ in vitro, its specific role in driving fibrotic scar formation after SCI has not been determined.