Publications by authors named "Outi Vaisanen"

Background: The electroencephalography (EEG) is an attractive and a simple technique to measure the brain activity. It is attractive due its excellent temporal resolution and simple due to its non-invasiveness and sensor design. However, the spatial resolution of EEG is reduced due to the low conducting skull.

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We present the four key areas of research-preprocessing, the volume conductor, the forward problem, and the inverse problem-that affect the performance of EEG and MEG source imaging. In each key area we identify prominent approaches and methodologies that have open issues warranting further investigation within the community, challenges associated with certain techniques, and algorithms necessitating clarification of their implications. More than providing definitive answers we aim to identify important open issues in the quest of source localization.

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We have developed a multielectrode lead technique to improve the signal-to-noise ratio (SNR) of scalp-recorded electroencephalography (EEG) signals generated deep in the brain. The basis of the method lies in optimization of the measurement sensitivity distribution of the multielectrode lead. We claim that two factors improve the SNR in a multielectrode lead: (1) the sensitivity distribution of a multielectrode lead is more specific in measuring signals generated deep in the brain and (2) spatial averaging of noise occurs when several electrodes are applied in the synthesis of a multielectrode lead.

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Article Synopsis
  • Introduces a new parameter called region of interest sensitivity ratio (ROISR) that assesses how specific EEG measurements are to their intended sources within a defined area.
  • Analyzes the impact of interelectrode distance on ROISR using a spherical head model, highlighting differences in sensitivity for cortical and non-cortical regions.
  • Demonstrates that ROISR correlates with signal-to-noise ratio (SNR) in EEG measurements, suggesting that optimizing electrode configurations can enhance measurement quality in future studies.
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The purpose of the present study is to conduct preliminary experimental measurements to validate the improvement in the detection of deep EEG sources achieved with new multielectrode EEG leads. As a measurement we had brainstem auditory evoked potentials (BAEPs), which include deep generators in the brainstem and midbrain. The BAEPs were measured with a 124-channel EEG cap.

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