Publications by authors named "Outi Lyytinen"
Microbial production of lipid-protein vesicles using enveloped bacteriophage phi6.
Microb Cell Fact
February 2019
Background: Cystoviruses have a phospholipid envelope around their nucleocapsid. Such a feature is unique among bacterial viruses (i.e.
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- The study focuses on the replication cycle of double-stranded RNA viruses, particularly how the viral RNA-dependent RNA polymerase (RdRP) functions within the viral capsid of the human picobirnavirus (hPBV).
- Researchers determined the structure of the hPBV RdRP, highlighting a unique flexible loop that plays a crucial role in RNA replication.
- The findings indicate that the RdRP is active with both single-stranded and double-stranded RNA, relies on viral RNA for capsid incorporation, and shows a preference for specific RNA sequences during transcription.
Sortase-dependent surface pili (or fimbriae) in Gram-positive bacteria are well documented as a key virulence factor for certain harmful opportunistic pathogens. However, it is only recently known that these multi-subunit protein appendages are also belonging to the "friendly" commensals and now, with this new perspective, they have come to be categorized as a niche-adaptation factor as well. In this regard, it was shown earlier that sortase-assembled piliation is a native fixture of two human intestinal commensalics (i.
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