Publications by authors named "Ourania Katopodi"
Background/aim: The use of multi-gene panels for germline testing in breast cancer enables the estimation of cancer risk and guides risk-reducing management options. The aim of this study was to present data that demonstrate the different levels of actionability for multi-gene panels used in genetic testing of breast cancer patients and their family members.
Materials And Methods: We performed an analysis in our clinical database to identify breast cancer patients undergoing genetic testing.
Background: Hereditary cancer predisposition syndromes are responsible for approximately 5-10% of all diagnosed cancer cases. In the past, single-gene analysis of specific high risk genes was used for the determination of the genetic cause of cancer heritability in certain families. The application of Next Generation Sequencing (NGS) technology has facilitated multigene panel analysis and is widely used in clinical practice, for the identification of individuals with cancer predisposing gene variants.
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- There is a gap in following international guidelines for managing metastatic colorectal cancer (CRC) in Greece and Cyprus, prompting the need for a new consensus on treatment strategies.
- An executive team from the Hellenic Society of Medical Oncology collaborated with international experts using the Delphi methodology to develop and vote on 109 statements regarding CRC management.
- The final consensus highlights the importance of a centralized approach, multidisciplinary care, adherence to guidelines, patient personalization, and that R0 resection is key for better oncological outcomes.
In rectal cancer management, accurate staging by magnetic resonance imaging, neo-adjuvant treatment with the use of radiotherapy, and total mesorectal excision have resulted in remarkable improvement in the oncological outcomes. However, there is substantial discrepancy in the therapeutic approach and failure to adhere to international guidelines among different Greek-Cypriot hospitals. The present guidelines aim to aid the multidisciplinary management of rectal cancer, considering both the local special characteristics of our healthcare system and the international relevant agreements (ESMO, EURECCA).
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- There is significant variation in colon cancer outcomes across European countries, particularly in Greece and Cyprus, largely due to differing management strategies and guideline adherence.
- A consensus for multidisciplinary colon cancer management was created based on European guidelines, involving extensive discussions and a structured Delphi voting process among international experts.
- Ultimately, the consensus included 60 statements on colon cancer management, achieving over 80% agreement, highlighting the need for centralized care, multidisciplinary teamwork, and strict adherence to established guidelines.
Colorectal cancer remains a major cause of cancer mortality in the Western world both in men and women. In this manuscript a concise overview and recommendations on adjuvant chemotherapy in colon cancer are presented. An executive team from the Hellenic Society of Medical Oncology was assigned to develop a consensus statement and guidelines on the adjuvant treatment of colon cancer.
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