Long-term evaluation of Ifosfamide-related nephrotoxicity in children.

Purpose: Ifosfamide is widely used in pediatric oncology but its nephrotoxicity may become a significant issue in survivors. This study is aimed at evaluating the incidence of late renal toxicity of ifosfamide and its risk factors.

Patients And Methods: Of the 183 patients prospectively investigated for renal function, 77 treated for rhabdomyosarcoma, 39 for other soft tissue sarcoma, 39 for Ewing's sarcoma, and 28 for osteosarcoma were investigated at least 5 years after treatment.

Testicular function of survivors of childhood cancer: a comparative study between ifosfamide- and cyclophosphamide-based regimens.

Purpose: This study aimed at comparing gonadal toxicity of ifosfamide versus cyclophosphamide received during childhood.

Methods: The evaluation was based on basal FSH measurement. LH and testosterone were also measured in most of the patients.