Publications by authors named "Oudessa Kerro"
Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations in isolated from extrapulmonary tuberculosis patients in western Ethiopia.
Basha Chekesa Harinder Singh Norberto Gonzalez-Juarbe Sanjay Vashee Rosana Wiscovitch-Russo Oudessa Kerro
Front Public Health
August 2024
Article Synopsis
- Extrapulmonary tuberculosis (EPTB) is a serious public health issue that often gets overlooked, so this study examines its genetic diversity, drug resistance, and transmission chains in western Ethiopia.
- Using whole-genome sequencing on samples from EPTB patients, researchers found that 87.64% of the bacteria belonged to a dominant lineage (Lineage-4) with varying sub-lineages, and a low rate of multi-drug resistance was observed.
- The study highlights a high clustering rate of infections, signaling the need for better TB control measures, and reveals that many drug-resistance mutations were not detected by standard diagnostic tests, showing the importance of advanced sequencing techniques.
Background: The lineage 4 (L4) of Mycobacterium tuberculosis (MTB) is not only globally prevalent but also locally dominant, surpassing other lineages, with lineage 2 (L2) following in prevalence. Despite its widespread occurrence, factors influencing the expansion of L4 and its sub-lineages remain poorly understood both at local and global levels. Therefore, this study aimed to conduct a pan-genome and identify genomic signatures linked to the elevated prevalence of L4 sublineages among extrapulmonary TB (EPTB) patients in western Ethiopia.
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