The effect of extended c, E and K matching in females under 45 years of age on the incidence of transfusion-induced red blood cell alloimmunisation.

Maternal alloantibodies directed against fetal red blood cell (RBC) antigens may cause potentially life-threatening haemolytic disease of the fetus and newborn (HDFN). Dutch transfusion guidelines therefore prescribe preventive cEK matching for all (pre-)fertile females. To quantify the impact of cEK matching, we compared overall and antigen-specific cumulative RBC alloimmunisation incidences in females and males aged <45 years.

Association between renal failure and red blood cell alloimmunization among newly transfused patients.

Background: Renal failure and renal replacement therapy (RRT) affect the immune system and could therefore modulate red blood cell (RBC) alloimmunization after transfusion.

Study Design And Methods: We performed a nationwide multicenter case-control study within a source population of newly transfused patients between 2005 and 2015. Using conditional multivariate logistic regression, we compared first-time transfusion-induced RBC alloantibody formers (N = 505) with two nonalloimmunized recipients with similar transfusion burden (N = 1010).

Correction of a dominant-negative von Willebrand factor multimerization defect by small interfering RNA-mediated allele-specific inhibition of mutant von Willebrand factor.

Unlabelled: Essentials Substitution therapy for von Willebrand (VW) disease leaves mutant VW factor (VWF) unhindered. Presence of mutant VWF may negatively affect phenotypes despite treatment. Inhibition of VWF by allele-specific siRNAs targeting single-nucleotide polymorphisms is effective.

SEM Based CARMA Time Series Modeling for Arbitrary N.

This article explains in detail the state space specification and estimation of first and higher-order autoregressive moving-average models in continuous time (CARMA) in an extended structural equation modeling (SEM) context for N = 1 as well as N > 1. To illustrate the approach, simulations will be presented in which a single panel model (T = 41 time points) is estimated for a sample of N = 1,000 individuals as well as for samples of N = 100 and N = 50 individuals, followed by estimating 100 separate models for each of the one-hundred N = 1 cases in the N = 100 sample. Furthermore, we will demonstrate how to test the difference between the full panel model and each N = 1 model by means of a subject-group-reproducibility test.

Development and Validation of the Computerized Family Relations Test for Children.

The aim of the present study was to develop and investigate the psychometric properties of the Computerized Family Relations Test (CFRT) for children. This test assesses the quality of family relationships with the mother and father from a child's perspective. The CFRT consists of six scales relating to control (Restrictiveness and Justice), and support (Affection, Vulnerability, Acknowledgment, and Trust) within the family relationships.

The Relationships between Individualism, Nationalism, Ethnocentrism, and Authoritarianism in Flanders: A Continuous Time-Structural Equation Modeling Approach.

This article analyzes the relationships among nationalism (N), individualism (I), ethnocentrism (E), and authoritarianism (A) in continuous time (CT), estimated as a structural equation model. The analysis is based on the General Election Study for Flanders, Belgium, for 1991, 1995, and 1999. We find reciprocal effects between A and E and between E and I as well as a unidirectional effect from A on I.

An SEM approach to continuous time modeling of panel data: relating authoritarianism and anomia.

Panel studies, in which the same subjects are repeatedly observed at multiple time points, are among the most popular longitudinal designs in psychology. Meanwhile, there exists a wide range of different methods to analyze such data, with autoregressive and cross-lagged models being 2 of the most well known representatives. Unfortunately, in these models time is only considered implicitly, making it difficult to account for unequally spaced measurement occasions or to compare parameter estimates across studies that are based on different time intervals.

Continuous time modelling with individually varying time intervals for oscillating and non-oscillating processes.

When designing longitudinal studies, researchers often aim at equal intervals. In practice, however, this goal is hardly ever met, with different time intervals between assessment waves and different time intervals between individuals being more the rule than the exception. One of the reasons for the introduction of continuous time models by means of structural equation modelling has been to deal with irregularly spaced assessment waves (e.

Reply to Steele & Ferrer: Modeling Oscillation, Approximately or Exactly?

This article addresses modeling oscillation in continuous time. It criticizes Steele and Ferrer's article "Latent Differential Equation Modeling of Self-Regulatory and Coregulatory Affective Processes" (2011), particularly the approximate estimation procedure applied. This procedure is the latent version of the local linear approximation procedure based on Boker (2001) and Boker, Neale, and Rausch (2004).

Perceptions of problem behavior in adolescents' families: perceiver, target, and family effects.

Considerable research has focused on the reliability and validity of informant reports of family behavior, especially maternal reports of adolescent problem behavior. None of these studies, however, has based their orientation on a theoretical model of interpersonal perception. In this study we used the social relations model (SRM) to examine family members' reports of each others' externalizing and internalizing problem behavior.

Male and female development of delinquency during adolescence and early adulthood: a differential autoregressive model of delinquency using an overlapping cohort design.

Although it is well known that during adolescence the delinquent involvement of females is consistently less when compared to male involvement, it remains an important question whether the development of delinquency has a similar trajectory for both sexes. The main hypothesis tested is whether sex differences in delinquency, specifically growth, peak age, and decline, are constant. An autoregression model in continuous time, implemented as a structural equation model, is used for the description of the development of delinquency in males and females.

Level validity of self-report whole-family measures.

This article introduces an approach to testing the level validity of family assessment instruments (i.e., whether a family instrument measures family functioning at the level of the system it purports to assess).

Current and recollected perceptions of family relationships: the social relations model approach applied to members of three generations.

Data from 81 three-generation families (comprising 567 participants) were analyzed to assess perceptions of current-family and family-of-origin relationships. The dimensions studied (Restrictiveness, Justice, Affection, and Trust) were derived from the family systems theories as developed by Boszormenyi-Nagy (I. Boszormenyi-Nagy & B.

Parents' reasons for enrolment of their motor-disabled child in a Dutch therapeutic toddler class.

This article describes and categorizes the reasons why parents enrol their motor-disabled children in the therapeutic toddler class, a special centre-based service in early intervention. The results among a representative Dutch sample of 84 mothers showed that child-related reasons were considered more important than family- and parent-related reasons. Family- and parent-related reasons were influenced by the presence and severity of the child's behaviour problems.

The rehabilitation process of children with motor disabilities in the Dutch therapeutic toddler class: main phases and parent involvement.

This study describes the implementation of the main phases of the rehabilitation process of children with motor disabilities who visit Dutch therapeutic toddler classes. Parent involvement, as well as parents' and professionals' satisfaction were also investigated. It was found that in about half of the cases there was no initial assessment of the child, nor a jointly formulated intervention plan.

Perceived changes in well-being of parents with a child in a therapeutic toddler class.

A 15-item questionnaire was developed to measure the perceived changes in well-being of parents with a motor disabled child during treatment in a Dutch therapeutic toddler class. Eighty-one mothers and 67 fathers completed the questionnaire. Factor analyses showed that two dimensions had to be distinguished in the questionnaire data.

Service needs of parents with motor or multiply disabled children in Dutch therapeutic toddler classes.

Objective: To determine parents' service needs at the start of therapeutic toddler class treatment, to analyse determinants and to investigate received help after a period of 10 months.

Subjects: Parents with motor or multiply disabled children in therapeutic toddler classes.

Setting: Sixteen out of 17 Dutch rehabilitation centres.

Chromosome no. 1 of Crepis capillaris shows defined 3D-shapes in mitotic prophase.

The shape of mitotic prophase chromosomes has been studied in root tip nuclei by confocal microscopy and 3D-image analysis. Crepis capillaris chromosome no. 1 was used as a test object.

The 5S rRNA gene clusters have a defined orientation toward the nucleolus in Petunia hybrida and Crepis capillaris.

The 3D localization of the 5S ribosomal RNA genes was studied in cells of the cortex zone of roots in the plant species Petunia hybrida inbred line V26 and in Crepis capillaris. The analysis was carried out on interphase nuclei (both species) and on prophase nuclei (C. capillaris).

Characterisation of the nucleolar organising regions during the cell cycle in two varieties of Petunia hybrida as visualised by fluorescence in situ hybridisation and silver staining.

The cell cycle-dependent spatial position, morphology and activity of the four nucleolar organising regions (NORs) of the Petunia hybrida cultivar Mitchell and the inbred line V26 have been analysed. Application of the silver staining technique and fluorescence in situ hybridisation on fixed root-tip material revealed that these interspecific hybrids possess four NORs of which only those of chromosome 2 are active during interphase, which implies that the NOR activity is not of parental origin. However, at the end of mitosis, activity of all NOR regions could be detected, suggesting that the high demand for ribosomes at this stage of the cell cycle requires temporal activity of all NORs.

The relationship between mutual family relations and child psychopathology.

The associations of the mutual mother-child, father-child, and mother-father relationship and various patterns of family relations with child psychopathology were investigated in a sample of 137 families referred to outpatient mental health services. Assessment of the relative association of the different family dyads showed that both the mother-child and the mother-father relationship were related to child problem behaviour. However, whereas the mother-child relationship was consistently more related to externalising behaviour, the mother-father relationship was particularly related to internalising behaviour.

There is an upper limit of chromosome size for normal development of an organism.

A clearly definable upper tolerance limit for chromosome arm length has been found. As a rule we postulate that, for normal development of an organism, the longest chromosome arm must not exceed half of the average length of the spindle axis at telophase. Above this length, fertility and viability of the carrier individuals become severely impaired due to increasingly incomplete separation of the longest chromatids during mitosis, resulting finally in the loss of DNA.

Shoot regeneration in long-term callus cultures derived from mature flowering plants of Cyclamen persicum Mill.

In long-term callus cultures of Cyclamen persicum Mill. two types of tissue could be distinguished. One type featured a brown suberised outer layer and was poorly organogenic.