Publications by authors named "Ou Hayashi"
Esaxerenone, a non-steroidal mineralocorticoid receptor (MR) blocker, exhibits high selectivity for MR. While clinically used as an anti-hypertensive drug, its impact on cardiac remodeling remains poorly understood. This study investigated the effect of esaxerenone on pressure overload-induced cardiac hypertrophy in mice.
View Article and Find Full Text PDFArticle Synopsis
- This study examines how changes in heart rate influence the recovery of left ventricular ejection fraction (LVEF) in patients with heart failure that initially has reduced ejection (HFrEF).
- Out of 398 patients who previously experienced heart failure, 138 with HFrEF were followed, leading to the identification of 64 patients who improved to heart failure with recovered ejection fraction (HFrecEF).
- The results indicate that a significant decrease in heart rate after hospitalization is a strong predictor of LVEF recovery, independent of other health factors.
Article Synopsis
- Lung subtraction iodine mapping-CT (LSIM-CT) is effective in showing blood flow issues in patients with chronic thromboembolic pulmonary disease (CTEPD), but its links to blood flow measurements are not well-defined.
- This study focused on the relationship between decreased pulmonary perfusion area (DPA) and mean pulmonary arterial pressure (mPAP), using specific DPA ratios based on lung images from 30 CTEPD patients.
- Results showed that the DPA ratio of 0-10 HU had a strong correlation with mPAP and pulmonary vascular resistance, with an optimal cutoff value of 8.5% predicting elevated mPAP levels effectively.
Article Synopsis
- Resistance exercise helps patients with lower extremity arterial disease, and this study investigates how muscle-derived exosomes, specifically those containing microRNAs (miRNAs), may encourage blood vessel formation in endothelial cells.* -
- Using a unique mouse model with induced muscle growth, researchers found that certain miRNAs, particularly miR206, increased significantly in the serum of these mice and were linked to enhanced angiogenic signaling pathways.* -
- The study concludes that the upregulated exosomal miR206 from growing muscle can promote angiogenesis in endothelial cells, suggesting its potential role in improving blood flow in related medical issues.*
Article Synopsis
- The study aimed to understand the clinical characteristics of heart failure with improved ejection fraction (HFimpEF) by looking at its association with initial clinical and echocardiographic parameters in patients with heart failure with reduced ejection fraction (HFrEF).
- It involved 128 outpatients who were categorized into two groups based on their heart function improvement over a year: those who improved their left ventricular ejection fraction (LVEF) to ≥40% and those who did not.
- The research found that a lower baseline E/e' ratio (an echocardiographic measure) was a key predictor of LVEF improvement in HFrEF patients, irrespective of factors like ischemic heart disease or heart rhythm issues.
Article Synopsis
- A 70-year-old man with severe interstitial pneumonia related to limited cutaneous systemic sclerosis experienced worsening breathing difficulties and low oxygen levels.
- High-resolution CT scans did not show significant lung progression, but tests indicated severe right heart dysfunction and high pulmonary arterial pressure.
- Following a vaso reactivity test with inhaled nitric oxide, the patient responded well to pulmonary hypertension-targeted medications, leading to significant improvements in his condition after three weeks of treatment.
Article Synopsis
- Research aimed to determine how these conditions relate to cardiovascular (CV) events in HD patients, analyzing data from 342 individuals and ultimately focusing on 244 who met the criteria.
- Results showed that those with sarcopenia had a significantly higher risk of CV events, while dynapenia also increased risk, indicating the need for clinicians to assess both muscle function and mass in this patient population.
Article Synopsis
- The study aimed to investigate the link between atherosclerosis in the femoropopliteal arteries and impaired blood flow in patients with peripheral arterial disease, using angioscopy to assess the condition.
- Out of 31 patients, 74.2% had ulcerated plaques (UPs), often linked to the presence of mural thrombi, indicating a higher risk of poor blood flow outcomes.
- The findings suggest that the presence of UPs was significantly associated with worse angiographic runoff scores, while the use of oral anticoagulants was linked to better blood flow outcomes.