Publications by authors named "Ottavia Bartolo"
Article Synopsis
- - Gastric cancer (GC) is a complex and aggressive type of cancer that starts in the stomach and can spread to other organs, often becoming deadly by stage IV.
- - The study analyzed gene expression data from 719 patients to identify a specific gene signature linked to the progression from stage I to stage IV GC, focusing on factors like ECM organization and epithelial-to-mesenchymal transition (EMT).
- - The findings suggest that this gene signature could help identify stage I patients at higher risk of progression, potentially aiding in early treatment strategies, while also providing a new experimental model to study how gastric cancer spreads.
The present document constitutes Part 2 of the EoETALY Consensus Statements guideline on the diagnosis and management of eosinophilic esophagitis (EoE) developed by experts in the field of EoE across Italy (i.e., EoETALY Consensus Group).
View Article and Find Full Text PDFArticle Synopsis
- * A group of Italian experts in EoE conducted a Delphi process to create updated management guidelines, which include the latest evidence and improve upon previous guidelines from the Italian Society of Gastroenterology (SIGE).
- * The new guidelines are split into two parts covering topics like the definition and diagnosis of EoE, as well as treatment and follow-up, and they have been endorsed by several Italian medical societies and incorporated feedback from patient associations.
Objectives: Rising trends in eosinophilic esophagitis (EoE) have been repeatedly linked to declining Helicobacter pylori (H. pylori) infection, mostly in retrospective studies. We aimed to prospectively evaluate this inverse association.
View Article and Find Full Text PDFThe 21st century offers new advances in diagnostic procedures and protocols in the management of esophageal diseases. This review highlights the most recent advances in esophageal diagnostic technologies, including clinical applications of novel endoscopic devices, such as ultrathin endoscopy and confocal laser endomicroscopy for diagnosis and management of Barrett's esophagus; novel parameters and protocols in high-resolution esophageal manometry for the identification and better classification of motility abnormalities; innovative connections between esophageal motility disorder diagnosis and detection of gastroesophageal reflux disease (GERD); impedance-pH testing for detecting the various GERD phenotypes; performance of distensibility testing for better pathophysiological knowledge of the esophagus and other gastrointestinal abnormalities; and a modern view of positron emission tomography scanning in metastatic disease detection in the era of accountability as a model for examining other new technologies. We now have better tools than ever for the detection of esophageal diseases and disorders, and emerging data are helping to define how well these tools change management and provide value to clinicians.
View Article and Find Full Text PDFBackground: Limited data are available on eosinophilic oesophagitis in Italy.
Aim: To evaluate typical features of eosinophilic oesophagitis patients in a tertiary centre.
Methods: 973 consecutive patients with dysphagia and/or bolus impaction were prospectively enrolled and underwent upper endoscopy for eosinophilic oesophagitis (≥15 eosinophils in at least one high-power field [hpf] and no response to acid suppressants).
Purpose: Wilson disease (WD) is a disorder of hepatic copper metabolism leading to copper accumulation in hepatocytes and in extrahepatic organs, as the brain and cornea. The aim of this study was to investigate central corneal changes and in particular to assess the parameters of corneal subbasal nerve plexus (SBNP) in patients affected by WD, using corneal confocal microscopy (CCM).
Methods: A total of 24 patients affected by WD and 24 healthy control subjects were included in this cross-sectional comparative study.