Publications by authors named "Ottakandathil Babu Rosana"
The success of checkpoint inhibitors (CPIs) for cancer has been tempered by immune-related adverse effects including colitis. CPI-induced colitis is hallmarked by expansion of resident mucosal IFNγ cytotoxic CD8 T cells, but how these arise is unclear. Here, we track CPI-bound T cells in intestinal tissue using multimodal single-cell and subcellular spatial transcriptomics (ST).
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- * In an experiment, human liver organoids treated with biliatresone were smaller and showed abnormal development compared to untreated control organoids, indicating detrimental impacts on liver cell organization and function.
- * The study found that biliatresone treatment reduced critical liver cell markers and disrupted important cellular features, suggesting that environmental toxins like biliatresone could play a role in the development of biliary atresia.
Group A (GAS) infection is associated with multiple clinical sequelae, including different subtypes of psoriasis. Such post-streptococcal disorders have been long known but are largely unexplained. CD1a is expressed at constitutively high levels by Langerhans cells and presents lipid antigens to T cells, but the potential relevance to GAS infection has not been studied.
View Article and Find Full Text PDFThe conditions and extent of cross-protective immunity between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and common-cold human coronaviruses (HCoVs) remain open despite several reports of pre-existing T cell immunity to SARS-CoV-2 in individuals without prior exposure. Using a pool of functionally evaluated SARS-CoV-2 peptides, we report a map of 126 immunogenic peptides with high similarity to 285 MHC-presented peptides from at least one HCoV. Employing this map of SARS-CoV-2-non-homologous and homologous immunogenic peptides, we observe several immunogenic peptides with high similarity to human proteins, some of which have been reported to have elevated expression in severe COVID-19 patients.
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- Bacterial wilt, caused by Ralstonia solanacearum, significantly impacts ginger production in warm regions, with a lack of resistant genotypes exacerbating the issue.
- The study utilized Illumina sequencing to analyze the transcriptomes of wilt-sensitive ginger and resistant mango ginger, revealing thousands of genes related to stress resistance and pathogen response.
- Findings include the identification of candidate genes linked to disease resistance in mango ginger and the development of a publicly accessible ginger transcriptome database for further research.