A simulation study of parameter estimation in the one and two compartment models.

Few attempts have been made to examine the statistical problems that the user of compartmental models must face. Some properties of the estimators of parameters for one and two compartmental models based on nonlinear estimation were studied through simulation. Of particular interest were the effect of the experimental design and the effect of different error structures on the empirical sampling distribution for the estimators.

Estimating pA2 values for different designs.

The method for analyzing data leading to the estimation of a pA2 depends on the experimental design. Three different experimental designs are discussed. For each design, we provide a brief description of experimental situations that give rise to the design, a means for verifying relevant assumptions, and sample data with summary calculations.

Genetic Control and Linkage Relationships among Aminopeptidases in Maize.

Maize aminopeptidase is coded by four genes. Amp1 and Amp2 have been localized to chromosome 1. A three-point cross shows the gene order to be Amp2-15%-Amp1-33%-Adh2 (alcohol dehydrogenase).

Effect of zimelidine (H 102/09) in depressive patients.

Z-1-(4-Bromophenyl)-1-(3-pyridyl)-3-dimethylaminopropene dihydrochloride hydrate (zimelidine; H 102/09), a newly developed bicyclic substance, was tested in a pilot study for its clinical effect in 10 female patients with a depressive syndrome. Zimelidine inhibits the 5-hydroxytryptamine (5-HT) reuptake more potently than does chlorimipramine. The action on the norepinephrine reuptake is weaker compared with imipramine, also the cardiotoxic and anticholinergic effects are lower.

Genetically defined peptidases of maize. I. Biochemical characterization of allelic and nonallelic forms.

A number of biochemical properties have been investigated for both allelic and nonallelic forms of maize peptidases. Four aminopeptidases exist in maize (LAP-A, LAP-B, LAP-C, and LAP-D) and are the products of four diallelic loci. The aminopeptidases fall into two biochemical groups on the basis of these studies.

Genetic control and intracellular localization of glutamate oxaloacetic transaminase in maize.

Glutamate oxaloacetic transaminase (L-aspertate: 2-oxoglutarate aminotransferase, E.C. 2.