Exploring sesquiterpene lactones: structural diversity and antiviral therapeutic insights.

Sesquiterpene lactones (SLs) are a structurally diverse group of secondary metabolites primarily produced by plants, particularly within the Asteraceae family. These compounds play significant roles in plant defense and have been extensively studied for their wide range of biological activities, including antiviral, antimicrobial, anti-inflammatory, and anticancer properties. This review focuses on the biosynthesis, structure-activity relationships, and biological activities of sesquiterpene lactones, with an emphasis on their antiviral potential.

Clinical Evaluation of 3D Motion-Correction Via Scout Accelerated Motion Estimation and Reduction Framework Versus Conventional T1-Weighted MRI at 1.5 T in Brain Imaging.

Objectives: The aim of this study was to investigate the occurrence of motion artifacts and image quality of brain magnetic resonance imaging (MRI) T1-weighted imaging applying 3D motion correction via the Scout Accelerated Motion Estimation and Reduction (SAMER) framework compared with conventional T1-weighted imaging at 1.5 T.

Materials And Methods: A preliminary study involving 14 healthy volunteers assessed the impact of the SAMER framework on induced motion during 3 T MRI scans.

Retrospective multicenter analysis of the Trenza Embolization Device for endovascular therapy of intracranial aneurysms: initial results and short-term follow-up.

Background: Intrasaccular devices are increasingly used in endovascular therapy of intracranial aneurysms, in particular wide-necked and ruptured aneurysms. The Trenza Embolization Device (TED) is an innovative intrasaccular device for medium- to large-sized aneurysms. Currently, literature about the TED is scarce.

Comparative assessment of empirical and hybrid machine learning models for estimating daily reference evapotranspiration in sub-humid and semi-arid climates.

Improving the accuracy of reference evapotranspiration (RET) estimation is essential for effective water resource management, irrigation planning, and climate change assessments in agricultural systems. The FAO-56 Penman-Monteith (PM-FAO56) model, a widely endorsed approach for RET estimation, often encounters limitations due to the lack of complete meteorological data. This study evaluates the performance of eight empirical models and four machine learning (ML) models, along with their hybrid counterparts, in estimating daily RET within the Gharb and Loukkos irrigated perimeters in Morocco.

Phospholipid Profiles in Mushrooms: A Review of Extraction, Analysis, and Functional Applications.

Mushrooms are widely recognized for their rich nutritional profile and diverse array of bioactive compounds, including proteins, polysaccharides, and secondary metabolites, which contribute to various health benefits. Among these compounds, phospholipids stand out due to their essential role in cellular processes and their potential applications in food, nutraceuticals, and pharmaceuticals. This review comprehensively examines the phospholipid composition in mushrooms, highlighting the methods of analysis, and delving into their functional applications.

Navigating Toxicity: Investigating the Interplay Between Workplace Gaslighting, Workaholism, and Agility Among Nurses.

Toxic workplace environments, especially those involving gaslighting, are known to contribute to stress and excessive work habits, such as workaholism, which may hinder a nurse's agility-an essential skill in adapting to fast-paced healthcare environments. However, the interplay between workplace gaslighting, workaholism, and agility in nursing remains underexplored. This study aims to investigate the relationship between workplace gaslighting, workaholism, and agility among nurses, focusing on how gaslighting moderates this relationship.

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Small Extracellular Vesicles Derived from Cord Blood Plasma and Placental Mesenchymal Stem Cells Attenuate Acute Lung Injury Induced by Lipopolysaccharide (LPS).

Sepsis is a risk factor associated with increasing neonatal morbidity and mortality, acute lung injury, and chronic lung disease. While stem cell therapy has shown promise in alleviating acute lung injury, its effects are primarily exerted through paracrine mechanisms rather than local engraftment. Accumulating evidence suggests that these paracrine effects are mediated by mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs), which play a critical role in immune system modulation and tissue regeneration.

Epilepsy Arabic renaming to cerebroelectric disorder could minimize the stigma.

Background: Naming is an important part of human communication. The precision of medical terms greatly influences the patients and their caregivers. "Alsara'الصرع " is the Arabic term defining epilepsy.

Characterization and evaluation of the immobilized laccase enzyme potential in dye degradation via one factor and response surface methodology approaches.

In the current study, calcium alginate was used as a carrier for Agaricus bisporus CU13 laccase immobilization, with an immobilization yield of the entrapped laccase of 91.95%. Free and immobilized enzymes showed their best enzyme activity at 60 °C as an optimum temperature.

Ramadan fasting in adolescents with epilepsy: Seizure control and behavioral outcome.

Data about the effect of Ramadan fasting on seizure control among adolescents with epilepsy (AWE) is scarce. Several psycho-behavioral problems have also been encountered in this teenage group. This study aimed to assess seizure frequency and behavioral outcomes after Ramadan fasting in a sample of AWE METHODS: In this prospective study, AWE who completed fasting during Ramadan 2024 were evaluated regarding the seizure frequency of each type during Shaban (the month immediately preceding Ramadan) and Ramadan.

Leaving no one behind: Gender inequality, economic inequality, and organizational entrenchment of nurses in remote areas of Egypt.

Aim: This study investigates the association between gender inequality, economic inequality, and organizational entrenchment among nurses serving in remote areas.

Background: Egypt ranks low in gender equity across the Middle East and North Africa (MENA) region. In the culture of nursing, gender-based discrimination is among the factors that can further hamper nurses' economic advancement and adversely affect organizational entrenchment.

The Critical Influence of Wire Diameter and Bending for Orthodontic Wire Integration-New Insights for Maxillary Movements (In Vitro Study).

: Traditional methods for palatal expansion using fixed appliances often face limitations in comfort and aesthetics. In comparison, aligner therapy has limitations, particularly regarding maxillary expansion. The aim of this study is to examine the biomechanical properties regarding the wire diameter and bending of different stainless steel wires to evaluate their potential for incorporation into maxillary aligner therapy.

Coenzyme Q improves mitochondrial and muscle dysfunction caused by CUG expanded repeats in Caenorhabditis elegans.

Expansion of nucleotide repeat sequences is associated with more than 40 human neuromuscular disorders. The different pathogenic mechanisms associated with the expression of nucleotide repeats are not well understood. We use a Caenorhabditis elegans model that expresses expanded CUG repeats only in cells of the body wall muscle and recapitulate muscle dysfunction and impaired organismal motility to identify the basis by which expression of RNA repeats is toxic to muscle function.

Enhancing the classification of seismic events with supervised machine learning and feature importance.

The accurate classification of seismic events into natural earthquakes (EQ) and quarry blasts (QB) is crucial for geological understanding, seismic hazard mitigation, and public safety. This paper proposes a machine-learning approach to discriminate seismic events, particularly differentiating between natural EQs and man-made QBs. The core of this study is to integrate different features into a unified dataset to train some linear and nonlinear supervised machine learning (ML) models.

Reliability of Automated RECIST 1.1 and Volumetric RECIST Target Lesion Response Evaluation in Follow-Up CT-A Multi-Center, Multi-Observer Reading Study.

Objectives: To evaluate the performance of a custom-made convolutional neural network (CNN) algorithm for fully automated lesion tracking and segmentation, as well as RECIST 1.1 evaluation, in longitudinal computed tomography (CT) studies compared to a manual Response Evaluation Criteria in Solid Tumors (RECIST 1.1) evaluation performed by three radiologists.

Evaluation of gastric tolerability for long-term use of diclofenac and celecoxib in male albino rats and potential gastroprotective benefits of royal jelly: a randomized controlled trial.

Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are used for pain and inflammation relief. Our study aimed to explore the ulcerogenic effect of long-term diclofenac and celecoxib administration on male albino stomachs, focusing on the possible gastroprotective effect of royal jelly administration.

Methods: Five equal groups of 50 male albino rats.

Acceptability, feasibility, and impact of the MyGut digital health platform in the monitoring and management of inflammatory bowel disease.

Background: Digital health monitoring may help facilitate self-management strategies when caring for patients with inflammatory bowel disease (IBD).

Aims: This study investigated the feasibility of implementing the MyGut health application when caring for patients with IBD and evaluated whether its use improved health outcomes.

Methods: We conducted a prospective trial in 2 Canadian hospitals from 2020 to 2023.

Comparison of two approaches to quadratus lumborum block for postoperative analgesia in radical cystectomy: a randomized clinical trial.

Background: The aim of this study was to evaluate the analgesic effects following radical cystectomy using two ultrasound guided QLB techniques: anterior and intramuscular.

Methods: Sixty patients aged 40-60 years old with ASA I, II were considered for this study. They were divided into two equal groups.

DSA-based perfusion parameters versus TICI score after mechanical thrombectomy in acute ischaemic stroke patients: a congruence analysis.

Background: Several factors are frequently considered for outcome prediction rin stroke patients. We assessed the value of digital subtraction angiography (DSA)-based brain perfusion measurements after mechanical thrombectomy (MT) for outcome prediction in acute ischaemic stroke.

Methods: From DSA image data (n = 90; 38 females; age 73.

Efficacy of the Modified Alvarado Scoring System and Radiologic Studies in Diagnosing Appendicitis in Children: A Retrospective Comparative Study.

Background: Appendicitis is a common diagnostic challenge in pediatric patients. Based on clinical and laboratory findings, the modified Alvarado scoring system (MAS) is commonly used to assess the likelihood of appendicitis. This study aims to evaluate the diagnostic performance of MAS compared to radiologic findings and its components in the diagnosis of appendicitis in children.

Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality.

Background: The vitamin D binding protein (DBP) plays a critical role in both innate and adaptive immune systems, participating in several clinical conditions, including coronavirus disease 2019 infection severity, and mortality rate. The study aimed to investigate the correlation between rs7041 and rs4588 polymorphisms in the DBP gene and Coronavirus Disease-2019 (COVID-19) severity and mortality, in patients of Suez Canal University Hospitals in Ismailia, Egypt.

Methods: A case-control study enrolled 220 individuals; 140 COVID-19 patients and 80 healthy controls.

An Atypical Presentation of a Pediatric Mature Teratoma: A Case Report and Review of the Literature.

Immature teratoma is an uncommon type of malignant tumor that mostly consists of immature tissue originating from the neuroepithelium. Mature teratomas in pediatrics are relatively rare and difficult to diagnose because of various symptoms and the tendency to overlap with other illnesses. This study aimed to report a rare case of a mature teratoma in pediatric age.