Predictors of anthracycline-induced cardiotoxicity in a retro-prolective cohort of children surviving cancer.

Introduction: Cardiotoxicity is an adverse reaction associated with the use of anthracyclines.

Objective: To estimate the factors associated with the development of anthracycline cardiotoxicity in pediatric patients surviving cancer.

Method: Retro-prolective cohort of children diagnosed with cancer and treated with anthracyclines.

Expression of the growth hormone receptor isoforms and its correlation with the metabolic profile in morbidly obese subjects.

Background And Aim Of The Study: Given the lipolytic effect of GH and its potential role in determining adipose tissue distribution, we evaluated the expression of the GH hormone receptor (GHR) isoforms in patients with morbid obesity seeking associations with metabolic parameters.

Methods: 262 morbidly obese subjects (mean age 42.5 ± 11 years, 75% women) underwent PCR-genotyping of the exon 3 GHR polymorphism.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

Background: Anthracyclines are effective drugs in pediatrics cancer treatment. However, anthracycline-induced cardiotoxicity (AIC) is a serious adverse drug reaction that affects the survival in patients treated for childhood cancer.

Clinical Cases: Case 1: Nine-year-old girl with stage IV Hodgkin lymphoma with 12 epirubicin doses and a cumulative dose of 576 mg/m2.

[Effectiveness of the outpatient treatment of the community-acquired pneumonia: systematic review and meta-analysis].

Background: Community-acquired pneumonia is an important cause of mortality and morbidity worldwide. Therefore, our aim was to assess the efficacy and safety of outpatient treatment of community-acquired pneumonia.

Methods: We systematically reviewed randomized clinical trials evaluating efficacy and safety of outpatient treatment (OPT) compared with inpatient treatment (IPT) of community-acquired pneumonia in patients without added co-morbidity.

Bladder agenesis and incomplete kidney duplication: Ileal reservoir with continent diversion as definitive treatment.

Bladder agenesis is an extremely rare entity. A 12-year-old female patient presented with urinary incontinence, recurrent urinary tract infections, visible vaginal introitus and urethra, and two holes at the vulvar vestibule. An investigation revealed bladder agenesis.

[Surgical treatment of hypospadias and complications in relation to the child's age].

Background: Hypospadias is one of the most common congenital malformations. Few studies have explored the association of age at time of surgery and the occurrence of complications after hypospadias repair.

Objective: Determine whether age at hypospadias repair is a risk factor for development of complications.