Publications by authors named "Osvaldo Rodrigues de Souza Neto"
Background: Considering the significant participation of the microenvironment in the local aggressiveness of odontogenic keratocysts, this study aims to evaluate the expression of ADAMTS-1 and its substrates, versican, aggrecan and brevican in this locally invasive odontogenic cyst.
Methods: Immunohistochemistry and polymerase chain reaction (PCR) were conducted on 30 cases of odontogenic keratocysts (OKCs) and 20 dental follicles (DFs).
Results: The immunohistochemical expression of these proteins was predominantly cytoplasmic and granular across all samples.
Article Synopsis
- * The research analyzed tissue samples from 20 cases of ameloblastoma and 10 dental follicles, employing various techniques like RT-PCR and immunofluorescence to assess the expression levels of the target proteins.
- * Results indicated that ADAMTS-1 was more highly expressed in ameloblastoma, suggesting it could be involved in tumor invasion by degrading the extracellular matrix component versican.
Background: ADAMTS expression can be associated with several inflammatory processes, and has been correlated with tumorigenesis of some neoplasms, but its participation in the development of periapical lesions has not been investigated. Therefore, our objective was to verify the expression of ADAMTS-1, versican and pEGFR in Periapical Granuloma (PG) and in the Radicular Cyst (RC) since they are the most common lesions of the periapex.
Methods: 25 samples of RC and 10 of PG were used.