[Immunological parallels in the use of ultraviolet irradiation of autoblood in patients with suppurative diseases of soft tissue].

Ultraviolet irradiation of autoblood in patients with suppurative diseases of soft tissues increased the titer of specific antibacterial antibodies and the number of antibody-producing cells (APC), which was the most expressed in cases when the erythrocytes and leukocytes were exposed separately. Study of the count of APC during UV exposure showed it to increase 6-8 h after the procedure.

[The Multicenter Captopril and the Quality of Life Study: the effect of antihypertensive agents from the basic groups on the quality of life of patients in different populations. The working group of the Multicenter Captopril and the Quality of Life Study].

This multicenter trial included 205 males aged 30-60 years with stable mild and moderate hypertension. 140 patients were from Moscow (140 patients), St. Petersburg, Kursk, Rostov (Russia); Kharkov, Donetsk (Ukraine); Baku (Azerbaijan).

[The pharmacokinetics of propranolol and its conjugated metabolites in patients with chronic ischemic heart disease and arterial hypertension with a one-time and course intake of the drug].

Pharmacokinetics of propranolol (P), 4-hydroxy-propranolol sulfate (4HOP-Sulf), and glucoronides of pharmacologically active S-enantiomer P (S-PG) and ballast R-enantiomer of P (R-PG) in the blood serum of 21 patients with chronic ischemic heart disease and/or arterial hypertension has been studied at a single and course oral P administration. The values od AUC and T1/2 for potentially active 4HOP-Sulf were significantly higher than those for unchanged P at a single and course administration. The values od AUC and T1/2 for for S-PG were approximately three times higher than those for P-PG after both a single and course administration.

[The long-term monotherapy with preparations from the 4 basic groups of antihypertensive agents of patients with mild and moderate arterial hypertension. The Multicenter Captopril and the Quality of Life Study. The working group of the Multicenter Captopril and the Quality of Life Study].

A multicenter randomized controlled trial was performed to compare antihypertensive effects and tolerance of captopril monotherapy with those of reference drugs from three other main groups of antihypertensive drugs: propranolol, hydrochlorothiazide, nifedipine. The trial included 345 males with essential hypertension stage I-II by WHO criteria. Evaluable patients after 8 months of treatment comprised 85.

[The effect of long-term monotherapy with preparations from the 4 basic groups of antihypertensive agents on the quality of life in patients with mild and moderate arterial hypertension. The Multicenter Captopril and the Quality of Life Study. The working group of the Multicenter Captopril and the Quality of Life Study].

A multicenter, controlled, open, randomized trial of antihypertensive and life quality (LQ) effects of monotherapy with captopril vs propranolol, hydrochlorothiazide and nifedipine included 345 males aged 35-60 years with mild and moderate hypertension. The results of 8-month treatment provided the conclusions: the drugs were much alike by antihypertensive efficacy, LQ parameters proved more beneficial in the group on captopril than those on nifedipine and propranolol, hydrochlorothiazide failed to improve life quality, captopril is an effective and safe antihypertensive drug superior to the drugs of 3 other antihypertensive drug groups by positively affecting LQ.

[Results of clinical investigation of anti-nicotine drug patches].

The paper gives the results of clinical trials of antinicotinic therapeutical films containing anabasinum, cytisinum or their combination in equal ratios. They were used in 74 patients with chronic nicotinism. The level of the drug in a film was 1.

[The efficacy of proxodolol in patients with stable arterial hypertension].

The new original Russian drug proxodolol having alpha- and beta-adrenoblocking activities in a ratio of 1:100 was examined at Stages I and II of clinical trials. The drug was given to 29 male patients aged 30-63 years who suffered from Stages I and II persistent hypertensive disease with a baseline diastolic blood pressure of >95 mm Hg. Proxodolol as 10- and 40-mg tablets was demonstrated to be an effective antihypertensive agent, its antihypertensive effects being revealed in acute and chronic uses.

[Differences in hemodynamic effects of the cardioselective beta-adrenoblocker acebutolol and non-selective beta-adrenoblocker propranolol in long-term antihypertensive therapy].

The cardioselective beta-adrenoblocker acebutolol used as a course therapy for 12 weeks was found to be a highly beneficial antihypertensive agent. The antihypertensive effect of the agent given in doses of 400-800 mg/day was as pronounced and prolonged as that of propranolol, 80-160 mg/day, though there is a tendency for acebutolol to show its complete or partial antihypertensive effect rather at the end of monotherapy than propranolol. At the same time the bradycardiac effect was more pronounced in propranolol therapy.

[The pharmacokinetics of the prolonged-action beta-adrenoblocker nadolol in hypertension patients after a single administration].

The pharmacokinetics of the beta-adrenoceptor blocker nadolol was studied in 30 patients suffering from mild hypertension given a single 80 mg dose of the drug. It has been shown that distribution of the pharmacokinetic parameters in this sample can be assumed normal. Their averages are similar to the reported data on healthy subjects.

[The efficacy of nitrendipine in patients with stable arterial hypertension. The data from a cooperative study in the USSR. The Working Group for the Cooperative Study of Nitrendipine].

Nitrendipine (bypress) manufactured by Bayer Company in the form of 10 and 20 mg tablets and administered in a dose of 20-40 mg/day turned out an effective antihypertensive remedy in 65% of patients with arterial hypertension largely running a mild course. The effect of nitrendipine administered in a single daily dose of 20 mg did not differ from that attained with the same dose given in two intakes. The raising of the daily dose of nitrendipine from 20 to 40 mg was associated with augmentation of the hypotensive effect in 43.

[Screening of single doses of the main antihypertensive drugs at rest and during various exercise tests in patients with hypertension].

The single doses of three reference antihypertensive drugs: corinfar (20 mg), anapriline (80 mg), and hypothiazide (50 mg) were screened on day 5 of drug administration at rest and during paired isometric and dynamic exercises in comparison to placebo. There was a significant decrease in blood pressures: systolic (SBP), diastolic (DBP), and mean (MBP) (p less than 0.01-0.

[Value of isometric and dynamic exercise tests with standard drug doses for selecting long-term antihypertensive treatment with vasodilators, adrenergic beta blockaders and diuretics].

The paper presents the results of the study into the efficacy of single routine doses of essential antihypertensive agents (nifedipine, propranolol, and hydrochlorothiazide) versus its course treatment at rest and during isometric and dynamic exercise tests. The efficacy was assessed by using the Dixon criterion. The routine drug dose tests performed at rest and during isometric and dynamic exercise were shown to have a varying informative value in the prediction of long-term treatment with the above drugs.

[Effect of propranolol on the indicators of carbohydrate metabolism and lipid transport in patients with diabetes mellitus type 2].

The paper is concerned with some data on the time course of indices of carbohydrate metabolism and lipid spectrum in patients with type II diabetes mellitus with concomitant CHD or arterial hypertension during therapy with mean doses of propranolol. The course treatment with propranolol resulted in the deterioration of carbohydrate metabolic indices and unfavorable shifts in the lipid spectrum of some patients. Patients on insulin therapy might demonstrate a significant decrease in the blood sugar level after physical exercise.

[Angina of effort as an unfavorable prognostic factor].

A seven-year prospective study of a random 10% sample of a population of 50- to 59-year-old males from one municipal district in Moscow is reported. Mortality was reviewed among patients with complicated angina pectoris, i.e.

[Changes in the indices of carbohydrate metabolism, of the lipoprotein spectrum and of the blood coagulation system in men with ischemic heart disease undergoing long-term propranolol treatment].

The paper is concerned with evidence of the time course of blood sugar, lipoprotein spectrum and some values of the blood coagulation system in patients with CHD on prolonged propranolol therapy in comparison with their natural time course in a similar group of patients with CHD receiving no therapy. Propranolol therapy for 2 yrs. produced no changes in the lipoprotein spectrum and blood fibrinogen.

[Characteristics of patients with ischemic heart disease under dispensary observation in a regional polyclinic and the evaluation of anti-angina therapy conducted under dispensary conditions].

An analysis has been made of the structure of a group of patients with coronary heart disease (CHD) subjected to prophylactic control in a city polyclinic and the antianginal treatment performed has been assessed. Clinical examination of 85 patients with diagnosed CHD and angina pectoris (AP) and 111 patients with diagnosed CHD only, demonstrated AP in 46.7 and 35.

[CNS pathology in hereditary syndromes of congenital developmental defects].

Analysis of the incidence and diagnostic importance of the congenital central nervous system (CNS) defects in 334 children with multiple congenital developmental defects (MCDD) dying under 1 year allowed the author to distinguish 4 groups of defects according to their informative value for establishing the nosological diagnosis: defects of a high, moderate, small informative value and noninformative ones. Special microscopic study of the CNS performed in 116 stillborns and children of the first year of life with various MCDD showed the disturbance of main morphogenetic processes (mitotic cell activity, cell migration, differentiation and maturation) as a basis of the observed pathological conditions. General rules of the CNS developmental defects in chromosomal and non-chromosomal syndromes may point to the common routes of the genetic material realization.

[Changes in the resting ECG in males with impaired carbohydrate tolerance of different degrees without clinical symptoms of ischemic heart disease and arterial hypertension].

The resting ECGs were analyzed in males aged 20-60 years with various tolerance to carbohydrates. There were statistically significant differences between the values characterizing the functions of automatism and conductivity on the resting ECG in patients with diabetes mellitus without any clinical symptoms of coronary heart disease (CHD), arterial hypertension, cardiac failure and other chronic diseases and in healthy males with the normal tolerance to carbohydrates. in patients with borderline impairments of carbohydrate tolerance (CT), these parameters occupied an intermediate position between the corresponding values in patients with diabetes mellitus and in subjects with the normal tolerance to carbohydrates.

[Evaluation of the stability and prognostic significance of identification of various risk factors of ischemic heart disease in 50 to 59-year-old men].

The authors present the data on the prevalence of coronary heart disease (CHD) and its risk factors, on the incidence of new cases of CHD and the associated mortality in the unorganized population of 50-59-year-old men of Moscow as well as findings on the natural variability of risk factors obtained over six years in a follow-up study. The relationship between the CHD incidence on the one hand and the baseline arterial pressure levels, excessive body weight and smoking habit on the other is evaluated. Arterial hypertension is shown to be the most prognostic risk factor of CHD in the unifactorial analysis.

[Pathological anatomy of monogenic syndromes of multiple congenital developmental defects].

Morphological study, with no selection, is performed of 1106 stillborns and children died before one year of age with congenital malformations (CM), 536 (46.9 +/- 1.5%) among them having multiple CM.

[Major results of a long-term prospective study of a male population].

The results of a prospective study of a Moscow population of males aged 50-59, represented in 4 independent samples (each numbering 500 subjects), are reported. Two examinations were conducted at a 6.5-year interval, and mortality was reviewed in the examined population.

[Pathology of hydranencephaly].

Data on pathological manifestations of hydranencephaly (3 cases) consisting of complete or nearly complete absence of cerebral hemispheres with the intact stem, cerebellum, spinal cord, meninges and skull bones are presented. A number of structural disorders were found in the remaining structures of the brain. A hypothesis on the origin of this central nervous system developmental defect is proposed: hydranencephaly is associated with disorders in the development of leptomeninges at the early stages of embryogenesis.