Publications by authors named "Osterhoff G"
Trauma causes the breakdown of membrane phospholipids and the subsequent degradation of the released polyunsaturated fatty acids (PUFAs) to partially bioactive oxylipins. Here, we screened for circulating PUFAs and oxylipins in patients (n = 34) differing from those of uninjured controls (n = 25) and analyzed their diagnostic potential. Patients were followed up for 1 to 240 h after minor/moderate, severe, and very severe injuries.
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- - Osteoarthritis (OA) is a degenerative condition that often requires total hip replacement, especially in aging populations, leading to anticipated increased demand for Total Hip Arthroplasty (THA) among those over 80 years old.
- - A systematic review analyzed data from eight studies, encompassing 494,144 patients, and found that perioperative mortality rates for octogenarians ranged from 0.33% to 1.96%, with extended hospital stays but similar surgical complication rates compared to younger patients.
- - The review concluded that age should not be the sole factor preventing octogenarians from undergoing THA, emphasizing that decisions should be based on overall health and comorbidities instead.
Background: The German hospital landscape is undergoing comprehensive changes due to the increasing aging population and staff shortages in the healthcare sector. These changes are driven by the current hospital reform and the guidelines of the Federal Joint Committee (G-BA) for the treatment of proximal femoral fractures.
Objective: To investigate the effects of the hospital reform and the implementation of the G‑BA guidelines for the treatment of proximal femoral fractures in Saxony.
Background: The aim of this study was to identify the most responsive foot position for detection of isolated unstable syndesmotic injury.
Methods: Fourteen paired human cadaveric lower legs were positioned in a pressure-controlled radiolucent frame and loaded under 700 N. Computed tomography scans were performed in neutral position, 15° internal / external rotation, and 20° dorsal / plantar flexion of the foot before and after cutting all syndesmotic ligaments.
Background: The significance of computed tomography (CT)-based volume measurement of the inferior vena cava (IVC) in the treatment and prognosis of trauma patients is not yet fully understood. The conflicting results that have been reported may be attributable to differences in injury severity and the use of different measurement methods, including IVC index and volumetry. The purpose of this study was to determine the relationship between IVC volume and red blood cell (RBC) transfusion and mortality in intubated trauma patients who were stable enough for initial CT imaging.
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- The study focused on periprosthetic femur fractures (PPF) following total hip arthroplasty (THA) to assess mortality rates and risk factors associated with these fractures.
- Findings revealed a one-year mortality rate of 23.4% and a two-year rate of 29.2%, with significant risk factors including age, gender, type of treatment, and time of surgery.
- Surgery during normal working hours greatly reduced mortality rates, while revision arthroplasty resulted in lower mortality compared to conservative treatment or plate fixation.
Article Synopsis
- The study aimed to create an easy-to-use score, called the OF Pelvis Score, to help decide between non-operative and surgical treatments for patients with osteoporotic pelvic fractures.
- The score was developed through expert consensus based on extensive analysis of fractures and includes factors like fracture type, pain level, mobility, and overall health, categorizing scores below, above, or equal to 8 for treatment recommendations.
- In a retrospective evaluation of 107 patients, the score guided therapy decisions effectively, with a high compliance rate, and emphasized its adaptable nature as patient conditions evolve.
Article Synopsis
- This study explores how a visualization system can transmit real-time patient data from ambulances to emergency trauma rooms (ETR) to enhance timely medical interventions before and after a patient arrives.
- Researchers conducted in-depth interviews with 32 physicians from six hospitals in Germany and Switzerland to gather insights on a prototype system designed for this purpose.
- The findings indicate that real-time data can improve workflow in ETRs, with physicians emphasizing the need for adaptable and mobile interfaces that display critical information relevant to patient care, suggesting future research should assess the system's practical application in clinical settings.
Article Synopsis
- Body composition parameters, especially sarcopenia, are important for predicting 30-day mortality in severely injured trauma patients requiring mechanical ventilation.
- The study analyzed 472 trauma patients over 12 years, identifying that nearly half had visceral obesity and a significant portion had sarcopenia or sarcopenic obesity.
- Ultimately, sarcopenia was found to be a strong predictor of mortality risk, while no significant relationship was established between body composition and ICU length of stay or mechanical ventilation duration among survivors.
Article Synopsis
- The study looked into whether measurements from CT scans of the lumbar spine could serve as reliable indicators for findings usually assessed by MRI.
- Researchers analyzed data from 198 individuals who had both types of scans between 2006 and 2012, focusing on disc height and endplate degeneration across various lumbar segments.
- The results revealed a strong correlation between disc height from CT and MRI, suggesting that in emergency situations where CT is readily available, it can be a useful alternative to MRI for assessing spine conditions, particularly when disc height falls below 11 mm.
Article Synopsis
- About one-third of cervical spine injuries happen in the upper section, specifically between the base of the skull (occiput) and the second cervical vertebra, with 70% of injuries occurring at this location.
- Types of injuries in this area include atlas fractures, occipital condyle fractures, and injuries to ligaments associated with the upper cervical spine.
- Treatment options range from conservative therapy for stable injuries to surgical intervention for unstable cases, with the article covering details on injury frequency, diagnosis, classification, and standard treatment methods.
Texture analysis can provide new imaging-based biomarkers. Texture analysis derived from computed tomography (CT) might be able to better characterize patients undergoing CT-guided percutaneous bone biopsy. The present study evaluated this and correlated texture features with bioptic outcome in patients undergoing CT-guided bone biopsy.
View Article and Find Full Text PDFStudy Design: Systematic review.
Purpose: Osteoporotic vertebral fractures (OVFs) and degenerative spine conditions are age-related and associated with higher morbidity and mortality and greater health care costs. The relationship between OVFs and prevalent spine degeneration is rarely reported.
TraumaFlow-development of a workflow-based clinical decision support system for the management of severe trauma cases.
Int J Comput Assist Radiol Surg
December 2024
Article Synopsis
- The purpose of the study is to enhance decision-making in the resuscitation room for severely injured patients using a clinical decision support system called TraumaFlow, which helps in coordinating activities and recommending treatments.
- The system was built on medical guidelines and employed a workflow management approach through BPMN 2.0, along with a user-friendly web interface; an evaluation study with medical students and residents showed its effectiveness in training.
- Results indicated that TraumaFlow improved adherence to guidelines, increased confidence in decision-making, reduced errors, and was helpful for both less experienced and highly experienced medical professionals during polytrauma training.
Article Synopsis
- This study compared two surgical methods, locking plates (LP) and retrograde intramedullary nails (RIN), for treating periprosthetic distal femur fractures in patients between 2009 and 2020.
- It included 63 fractures from 59 patients, assessing complications, radiographic results, and functional outcomes through measurements and questionnaires.
- While the complication rates were similar, fractures treated with LP had a higher implant failure rate, and RIN led to more femur recurvation, but functional outcomes remained comparable for both treatment methods.
Article Synopsis
- The study investigates factors related to implant failure in patients with traumatic symphyseal disruptions treated with plate fixation, finding that none of the examined parameters predict failure rates.
- Over a six-year follow-up, 37% of patients experienced anterior implant failure, but this background did not significantly affect pain levels or functional outcomes, except for a slight improvement in the work-adjusted Majeed Pelvic Score for those with failures.
- The study concludes that while implant failure is not predictable, it may not have significant clinical consequences, suggesting that routine additional procedures to prevent failure might not be necessary, especially in asymptomatic patients.
Article Synopsis
- Surgeons experience high levels of physical stress during operations, leading to discomfort in the neck, shoulders, and back.
- This study tested the use of an upper body exoskeleton on surgeons performing surgeries, comparing their physical complaints with and without the device.
- Results showed that the exoskeleton significantly reduced pain and discomfort after surgery, indicating its potential as a supportive tool for surgeons.
Article Synopsis
- This study explored the use of virtual reality (VR) simulators to enhance surgical skills training for medical students, focusing on an elective course in a VR operating theater during summer 2023.
- Using Oculus Quest 2 headsets and the PrecisionOS platform, the 12 participating students trained on five surgical procedures while engaging in discussions and instructional videos, with their progress measured through questionnaires.
- Results showed that students found VR training beneficial, with 91% wanting more VR opportunities; those in the VR group scored significantly higher in procedural knowledge during the training compared to the non-VR group.
Objectives: Coronary artery calcifications detected by computed tomography (CT) provide prognostic relevance for vascular disorders and coronary heart disease, whereas their prognostic relevance in severely injured trauma patients remains unclear.
Material And Methods: All consecutive trauma patients requiring emergency tracheal intubation before initial CT at a level-1 trauma center and admission to the intensive care unit (ICU) over a 12-year period (2008-2019) were reanalyzed. The Weston score, a semiquantitative method to quantify coronary calcifications, was evaluated as a prognostic variable based upon whole-body trauma CT analysis.
Article Synopsis
- - This study investigates how metabolic changes in osteosarcoma influence the tumor immune microenvironment (TIME) and patients' prognoses using data from the TARGET and GEO databases, focusing on metabolic super-pathways and immune cell presence.
- - Four vital metabolic pathways were identified, with vitamin and cofactor metabolism being most linked to prognosis, and two distinct metabolic clusters (C1 and C2) showed differences in immune cell infiltration and chemotherapy response, while three gene clusters (GC1-3) were linked to varied prognoses.
- - A metabolism-related risk model was created, showing significant prognostic power and suggesting that low-risk patients had better immune cell infiltration; experimenting with the gene ST3GAL4 demonstrated its critical role in
Background: Visits to an outpatient cancer clinic represent a challenging situation for patients, which can trigger anxiety and helplessness in those affected. It is important to identify patients with high psychological distress as early as possible in order to provide them with supportive psychological interventions. The aim of this study was to validate the Distress Thermometer (DT), a widely used screening for distress, in a cohort of patients with musculoskeletal tumors and to explore associations between distress, treatment satisfaction and health literacy.
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- This research compares the performance of human researchers and OpenAI's ChatGPT in conducting systematic reviews of clinical articles, assessing how effectively both extract key information using natural language processing (NLP) models.
- The study found a high agreement level between ChatGPT and human researchers in most areas, although there were discrepancies regarding study design and clinical tasks, and highlighted five studies showcasing the diverse uses of NLP in clinical contexts.
- The conclusions emphasize the potential of NLP models like ChatGPT to enhance both healthcare efficiency and accuracy, while also recommending future research to expand applications and address ethical concerns in healthcare settings.
Article Synopsis
- Trauma triggers an immediate immune response to help clear damaged cells and their associated signaling molecules, known as DAMPs.
- In severely injured patients, neutrophils showed a consistent pattern of increased EMR2 expression, peaking at 48 hours post-injury, before declining in some cases.
- The study suggests that the rise in neutrophilic EMR2 is driven by damaged cells and DAMPs, potentially enhancing the body's ability to respond to trauma effectively.
Study Design: Multicenter prospective cohort study.
Objectives: Anxiety in combination with osteoporotic vertebral compression fractures (OVCFs) of the spine remains understudied. The purpose of this study was to analyze whether anxiety has an impact on the short-term functional outcome of patients with an OVCF.
Article Synopsis
- Multidisciplinary tumor conferences are essential for treating cancer patients, and the COVID-19 pandemic allowed a comparison between in-person and virtual formats.
- A study analyzed 209 first-time patient presentations during both conference styles and found that while virtual meetings had slightly fewer participants, they included more diverse disciplines and led to quicker patient discussions and shorter intervals between initial presentations and biopsies.
- The results suggest that virtual tumor conferences may enhance the speed and depth of care for musculoskeletal tumors, indicating they could be a regular part of cancer treatment moving forward.