Switching tinnitus on or off: An initial investigation into the role of the pregenual and rostral to dorsal anterior cingulate cortices.

Research indicates that hearing loss significantly contributes to tinnitus, but it alone does not fully explain its occurrence, as many people with hearing loss do not experience tinnitus. To identify a secondary factor for tinnitus generation, we examined a unique dataset of individuals with intermittent chronic tinnitus, who experience fluctuating periods of tinnitus. EEGs of healthy controls were compared to EEGs of participants who reported perceiving tinnitus on certain days, but no tinnitus on other days.

Investigating sensitivity to multi-domain prediction errors in chronic auditory phantom perception.

The perception of a continuous phantom in a sensory domain in the absence of an external stimulus is explained as a maladaptive compensation of aberrant predictive coding, a proposed unified theory of brain functioning. If this were true, these changes would occur not only in the domain of the phantom percept but in other sensory domains as well. We confirm this hypothesis by using tinnitus (continuous phantom sound) as a model and probe the predictive coding mechanism using the established local-global oddball paradigm in both the auditory and visual domains.

Phantom perception as a Bayesian inference problem: a pilot study.

Tinnitus is the perception of a continuous sound in the absence of an external source. Although the role of the auditory system is well investigated, there is a gap in how multisensory signals are integrated to produce a single percept in tinnitus. Here, we train participants to learn a new sensory environment by associating a cue with a target signal that varies in perceptual threshold.

The serial reproduction of an urban myth: revisiting Bartlett's schema theory.

Frederic Bartlett's schema theory is still widely misunderstood as claiming that remembering is inevitably unreliable. However, according to the logic of his schema theory, remembering should, in relation to certain kinds of material, be relatively . In this study we examined whether a "well-worn" urban myth (the ) could be exempt from the fate of other material used in Bartlett's own research on serial reproduction.

Schema and deviation effects in remembering repeated unfamiliar stories.

In today's globalized world, we frequently encounter unfamiliar events that we may have difficulty comprehending - and in turn remembering - due to a lack of appropriate schemata. This research investigated schema effects in a situation where participants established a complex new schema for an unfamiliar type of story through exposure to four variations. We found that immediate recall increased across subsequent stories and that distortions occurred less frequently - participants built on the emerging schema and gradually established representations of parts of the story that were initially transformed.

Dysregulation of adenosine kinase isoforms in breast cancer.

Dysregulated adenosine signaling pathway has been evidenced in the pathogenesis of breast cancer. However, the role of adenosine kinase (ADK) in tumorigenesis remains unclear while it crucially regulates the removal and availability of adenosine. ADK has two isoforms that localize to discrete subcellular spaces: i.

Structured word-lists as a model of basic schemata: deviations from content and order in a repeated event paradigm.

Repeated events are common in everyday life, but relatively neglected as a topic within memory psychology. In two samples of adults, we investigated memory for repeated, schema-establishing simple events (operationalised as structured word-lists), and the effects of deviations within those events. We focused on the effects of deviations from two core dimensions of schema: content and order.

Using metamemory measures and memory tests to estimate eyewitness free recall performance.

Using a mock witness methodology, we investigated the predictive value of metamemory measures and objective memory tests as indicators of eyewitness free recall performance. Participants ( = 208) first completed a metamemory assessment that included assessments of self-rated memory capacity, memory development and use of strategies. In a separate session, participants watched a mock-crime video and provided a free recall account, followed by one out of four independent memory tests (i.

Detecting feigned high impact experiences: A symptom over-report questionnaire outperforms the emotional Stroop task.

Background And Objectives: The Modified Stroop Task (MST) effect refers to a prolonged reaction time (RT) in color-naming words related to an individual's disorder. Some authors argue that its absence in people who claim symptoms might be an indication of feigning.

Method: We tested whether the MST effect is robust against feigning attempts and compared its absence as an index of feigning with over-reporting tendencies on a symptom questionnaire (i.

Low CO2 induces urea cycle intermediate accumulation in Arabidopsis thaliana.

The non-proteinogenic amino acid ornithine links several stress response pathways. From a previous study we know that ornithine accumulates in response to low CO2. To investigate ornithine accumulation in plants, we shifted plants to either low CO2 or low light.

The effect of occipital nerve field stimulation on the descending pain pathway in patients with fibromyalgia: a water PET and EEG imaging study.

Background: Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory, and mood problems. Recently, occipital nerve field stimulation (ONS) has been proposed as an effective potential treatment for fibromyalgia-related pain. The aim of this study is to unravel the neural mechanism behind occipital nerve stimulation's ability to suppress pain in fibromyalgia patients.

The effects of co-witness discussion on confidence and precision in eyewitness memory reports.

We examined the influence of co-witness discussion on the metacognitive regulation of memory reports. Participants (N = 92) watched a crime video. Later, a confederate confidently agreed with (gave confirming feedback), disagreed with (gave disconfirming feedback), or gave no feedback (control) regarding participants' answers to questions about the video.

Computer Mediated Social Comparative Feedback Does Not Affect Metacognitive Regulation of Memory Reports.

In two experiments, we investigated how social comparative feedback affects the metacognitive regulation of eyewitness memory reports. In Experiment 1, 87 participants received negative, positive, or no feedback about a co-witness's performance on a task querying recall of a crime video. Participants then completed the task individually.

Adding Prefrontal Transcranial Direct Current Stimulation Before Occipital Nerve Stimulation in Fibromyalgia.

Objectives: Fibromyalgia (FM) is a type of chronic musculoskeletal pain without a clear peripheral origin of nociception, often associated with depression. The underlying pathophysiology involves changes in a functional network that is related to pain and emotional processing in the central nervous system. Transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex or the occipital nerve (ON) is a noninvasive neuromodulation technique capable of improving fibromyalgia symptoms.

Resting state electrical brain activity and connectivity in fibromyalgia.

The exact mechanism underlying fibromyalgia is unknown, but increased facilitatory modulation and/or dysfunctional descending inhibitory pathway activity are posited as possible mechanisms contributing to sensitization of the central nervous system. The primary goal of this study is to identify a fibromyalgia neural circuit that can account for these abnormalities in central pain. The second goal is to gain a better understanding of the functional connectivity between the default and the executive attention network (salience network plus dorsal lateral prefrontal cortex) in fibromyalgia.

Differential effects of bifrontal and occipital nerve stimulation on pain and fatigue using transcranial direct current stimulation in fibromyalgia patients.

Fibromyalgia is a disorder characterized by widespread musculoskeletal pain frequently accompanied by other symptoms such as fatigue. Moderate improvement from pharmacological and non-pharmacological treatments have proposed non-invasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) to the occipital nerve (more specifically the C2 area) or to the dorsolateral prefrontal cortex (DLPFC) as potential treatments. We aimed to explore the effectiveness of repeated sessions of tDCS (eight sessions) targeting the C2 area and DLPFC in reducing fibromyalgia symptoms, more specifically pain and fatigue.

Progressive Consent and Specimen Accrual Models to Address Sustainability: A Decade's Experience at an Oregon Biorepository.

Background: The Legacy Biorepository is a College of American Pathologists-accredited biorepository operating within a seven-hospital healthcare system, with a decade's experience in specimen accrual, storage, and distribution. While standardization of our practices through accreditation remains a priority, we along with others face challenges with regard to sustainability. Purposeful changes in our consent process, which we term "progressive consent," are expected to improve sustainability and operational flexibility while increasing our scientific impact.

Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress.

Background: In this study we are using source localized neurofeedback to moderate tinnitus related distress by influencing neural activity of the target region as well as the connectivity within the default network.

Hypothesis: We hypothesize that up-training alpha and down-training beta and gamma activity in the posterior cingulate cortex has a moderating effect on tinnitus related distress by influencing neural activity of the target region as well as the connectivity within the default network and other functionally connected brain areas.

Methods: Fifty-eight patients with chronic tinnitus were included in the study.

A mega-analysis of memory reports from eight peer-reviewed false memory implantation studies.

Understanding that suggestive practices can promote false beliefs and false memories for childhood events is important in many settings (e.g., psychotherapeutic, medical, and legal).

The added value of auditory cortex transcranial random noise stimulation (tRNS) after bifrontal transcranial direct current stimulation (tDCS) for tinnitus.

Tinnitus is the perception of a sound in the absence of a corresponding external sound source. Research has suggested that functional abnormalities in tinnitus patients involve auditory as well as non-auditory brain areas. Transcranial electrical stimulation (tES), such as transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex and transcranial random noise stimulation (tRNS) to the auditory cortex, has demonstrated modulation of brain activity to transiently suppress tinnitus symptoms.

Adults' retractions of childhood sexual abuse allegations: high-stakes and the (in)validation of recollection.

Retractors are individuals who have repudiated their earlier claims of having been sexually abused. There has been relatively little research conducted with this population. The growing literature on memory verification strategies and non-believed memories provide a conceptual and empirical lens through which to revisit the accounts of these individuals to try and learn more about the process of making and retracting high stake, consequential beliefs or recollections about the past.

The Neural Correlates of Chronic Symptoms of Vertigo Proneness in Humans.

Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness. The vestibular network governs functions that might be impaired in patients affected with vestibular dysfunction. It is currently unclear how different brain regions/networks process vestibular information and integrate the information into a unified spatial percept related to somatosensory awareness and whether people with recurrent balance complaints have a neural signature as a trait affecting their development of chronic symptoms of vertigo.

Latent variables underlying the memory beliefs of Chartered Clinical Psychologists, Hypnotherapists and undergraduate students.

In courts in the United Kingdom, understanding of memory phenomena is often assumed to be a matter of common sense. To test this assumption 337 UK respondents, consisting of 125 Chartered Clinical Psychologists, 88 individuals who advertised their services as Hypnotherapists (HTs) in a classified directory, the Yellow Pages, and 124 first year undergraduate psychology students, completed a questionnaire that assessed their knowledge of 10 memory phenomena about which there is a broad scientific consensus. HTs' responses were the most inconsistent with the scientific consensus, scoring lowest on six of these ten items.

A Simple Technique for Surgical Placement of Occipital Nerve Stimulators without Anchoring the Lead.

Introduction Greater occipital nerve stimulation is applied in the treatment of occipital neuralgia, headache, and fibromyalgia. Multiple techniques have been described along with their subsequent complications. The most frequent complications are related to lead migration, infection, and undesired stimulation effects.