Publications by authors named "Osmel Alvarez"
Purpose: To develop and validate a deep learning (DL) model to differentiate ocular surface squamous neoplasia (OSSN) from pterygium and pinguecula using high resolution anterior segment optical coherence tomography (AS-OCT).
Design: Retrospective Diagnostic Accuracy Study METHODS: xxx.
Setting: Single Center STUDY POPULATION: All eyes with a clinical or biopsy-proven diagnosis of OSSN, pterygium, or pinguecula that received AS-OCT imaging.
Article Synopsis
- The study focuses on conjunctival keratoacanthomas, rare eye lesions, by analyzing patient data from 2005 to 2023, including clinical characteristics and treatment outcomes.
- Out of nine patients identified, most were middle-aged Hispanic males, with lesions commonly found in the right eye and on the temporal conjunctiva, showing rapid growth and specific imaging features.
- Histopathological examination revealed distinct features such as keratin-filled lesions, and after surgical removal, most patients (except two lost to follow-up) showed no recurrence over an average follow-up period.
Purpose: To present the first known cases of punctal and canalicular stenosis following topical 5-fluorouracil (5-FU) eye drops for ocular surface squamous neoplasia (OSSN).
Methods: A retrospective chart review of patients with OSSN receiving topical 1% 5-FU eye drops as a primary or adjuvant treatment between 2013 and 2021 was performed. Individuals diagnosed with punctal or canalicular stenosis during or after topical 5-FU use were included in this study.
Purpose: To determine the efficacy and safety of topical 1% 5-fluorouracil (5FU) eye drops as primary treatment of ocular surface squamous neoplasia (OSSN).
Methods: Patients were diagnosed with OSSN based on slit-lamp examination and anterior segment optical coherence tomography (AS-OCT). In ambiguous cases an incisional biopsy was performed.
Purpose: To assess the effect of mask wear on corneal topography and tomography readings.
Setting: Tertiary ophthalmic center.
Design: Prospective, observational, comparative study.
Management of ocular surface squamous neoplasia: Bowman Club Lecture 2021.
BMJ Open Ophthalmol
July 2021
The gold-standard treatment for ocular surface squamous neoplasia (OSSN) has traditionally been surgical excision with wide margins and a no-touch technique. However, surgery may be associated with several unfavourable sequelae, as well as significant recurrence rates if margins are positive. In recent years, topical chemotherapy with 5-fluorouracil, interferon α-2b and mitomycin C have emerged as valuable agents capable of effectively treating OSSN with varying adverse effects.
View Article and Find Full Text PDFPurpose Of Review: To discuss recent studies of imaging modalities for ocular surface pathologies.
Recent Findings: Novel micro-ocular coherence tomography technology can produce high-resolution images of corneal cellular and nervous structures. Ocular coherence tomography angiography can aid in detecting early stage limbal stem cell deficiency.
Introduction: Kaposi's sarcoma (KS) is a multifocal low-grade vascular neoplasm that can affect the skin, mucus membranes, visceral organs, and lymph nodes. KS can also affect the ocular surface and adnexa and can masquerade as other entities, delaying prompt diagnosis.
Areas Covered: In this review, the manifestations of ocular KS are discussed along with theories for pathogenesis, common risk factors, and management options.