Publications by authors named "Oskar Steinbrecher"
Extranodal marginal zone B-cell lymphoma of the mucosa associated lymphoid tissue (MALT-lymphoma) is an indolent B-cell lymphoma with a distinct affinity for mucosal structures. Most commonly arising in the stomach, only roughly 2% of MALT-lymphomas occur in the colon or the intestine. In view of this, we have retrospectively assessed all patients with MALT-lymphoma involving the intestine for clinicopathological characteristics.
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- Soft tissue sarcomas, like liposarcoma (LPS), are rare with high recurrence after surgery and poor outcomes when advanced.
- Eribulin is a chemotherapy drug approved for use in metastatic LPS after initial treatments fail, but its effectiveness post-surgery wasn't known until this study.
- The study found that five high-risk LPS patients treated with eribulin after surgery had a median progression-free survival of 12.3 months and overall survival of 44.3 months, with manageable side effects, suggesting eribulin may be a viable option for certain patients.
Introduction: Soft tissue sarcomas are rare and heterogenous malignancies with a poor prognosis in advanced disease stages. Eribulin is used in metastatic liposarcoma (LPS) patients, who have failed first-line chemotherapy and has been approved for use in patients with LPS in the USA and Europe due to its efficacy in this histological subtype in a phase 3 trial. We have evaluated efficacy and tolerability of eribulin in LPS and leiomyosarcoma (LMS) patients in the routine clinical setting at our department.
View Article and Find Full Text PDFBackground: Venous thromboembolism (VTE) is a frequent and potentially fatal disease, but its pathophysiology is incompletely understood. microRNAs (miR) dysregulate hemostatic proteins and influence thrombotic pathology by posttranscriptional regulation of gene expression. Consensus in defining VTE-related miR clusters and functionally relevant miR has not been reached.
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- Ewing sarcoma (ES) and osteosarcoma (OSA) are common bone tumors in young adults, with treatment involving chemotherapy and surgery; this study assessed the EURAMOS-A and EURO E.W.I.N.G. protocols.
- A total of 31 patients aged 18 to 39 were analyzed, revealing that most ES cases were localized in the thorax or pelvis, while OSA typically affected the lower extremities; a significant proportion required dose reductions during treatment.
- Both treatment protocols proved to be well-tolerated, suggesting that dose reductions for side effects may be more beneficial than delaying doses in these patients.
Introduction: D-dimer measured shortly after discontinuation of anticoagulation by an immunoturbidimetric assay predicts the risk of recurrent venous thromboembolism (VTE). We assessed the performance of this assay over time and its association with recurrent VTE.
Materials And Methods: We followed 556 patients with a first VTE for a median of 9.
Article Synopsis
- The study compared clopidogrel single antiplatelet therapy (SAPT) with clopidogrel-based dual antiplatelet therapy (DAPT) among 44 volunteers to assess their effects on blood coagulation and platelet activation.
- Both therapies significantly reduced platelet activation (MEA-ADP) at 2, 24 hours, and 8 days, but DAPT showed a stronger inhibitory effect, especially on arachidonic acid-triggered aggregation (MEA-AA).
- Results indicated that while both treatments reduced platelet and coagulation activation, DAPT was more effective in certain parameters, like lowering thromboxane B and d-Dimer levels, which did not change with SAPT.
Background: Patients with spinal cord injury (SCI) are at risk of thrombosis and bleeding. Data on the risks during rehabilitation are inconsistent, and thromboprophylactic strategies are heterogeneous. We aimed to evaluate the thrombotic risk and bleeding events of SCI patients during rehabilitation.
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