Anticancer Plant Secondary Metabolites Evicting Linker Histone H1.2 from Chromatin Activate Type I Interferon Signaling.

Previously we discovered that among 15 DNA-binding plant secondary metabolites (PSMs) possessing anticancer activity, 11 compounds cause depletion of the chromatin-bound linker histones H1.2 and/or H1.4.

The complete coding sequence of Influenza A/Unknown/Chelyabinsk/206/H7N4.

An influenza virus strain was obtained during a bird surveillance study in 2023 near Lake Chebarkul in the Chelyabinsk region, Russia. This complete coding genome sequence of the virus sampled from the Ural region significantly expands the knowledge about the spread of the H7N4 subtype of the influenza A virus.

Plasticity of Response Properties of Mouse Visual Cortex Neurons Induced by Optogenetic Tetanization In Vivo.

Heterosynaptic plasticity, along with Hebbian homosynaptic plasticity, is an important mechanism ensuring the stable operation of learning neuronal networks. However, whether heterosynaptic plasticity occurs in the whole brain in vivo, and what role(s) in brain function in vivo it could play, remains unclear. Here, we used an optogenetics approach to apply a model of intracellular tetanization, which was established and employed to study heterosynaptic plasticity in brain slices, to study the plasticity of response properties of neurons in the mouse visual cortex in vivo.

The influence of agrotechnologies of organic farming on the content of humus, phosphorus and potassium in the soil.

Organic agriculture is becoming an increasingly popular direction in modern agriculture. At the same time, some researchers and practitioners still have doubts about the ability of this technology to maintain the balance of nutrients in the soil. The article is a contribution to the study of the influence of long-term organic farming on agrochemical soil parameters.

The effectiveness of the use of selenium-containing top dressing in the cultivation of radish.

Vegetable crops of the Brassicaceae family have the ability to include the necessary trace element selenium (Se) in the composition of organic compounds such as selenoproteins, in addition, they have important properties for human health based on the content of selenium. In our work, we investigated the effect of non-root processing of vegetating radish plants on the quality of finished products. The research results showed that the selenium content in the product part of plants significantly increased with an increase in the concentration of this element in the working solution.

The Spectrum of Germline Nucleotide Variants in Gastric Cancer Patients in the Kyrgyz Republic.

Gastric cancer is a major challenge in modern oncology due to its high detection rate and prevalence. While sporadic cases make up the majority of gastric cancer, hereditary gastric cancer is caused by germline mutations in several genes linked to different syndromes. Thus, identifying hereditary forms of gastric cancer is considered crucial globally.

Medical Antennas for Microwave Radiothermometry of Biological Objects.

The results of an analytical review of various antennas used in medicine are presented. Issues of modern microwave radiothermometry related to the development of new antennas are discussed, as well as possible ways to solve them. The tasks of further research aimed at creating new designs for conformal antennas and antenna arrays providing a significant expansion of the functionality and improvements in the characteristics of medical radiothermographs are formulated.

[Clinical portrait of a patient with COVID-19. The experience of a multidisciplinary clinic].

Aim: Evaluation of the clinical characteristics in patients with COVID-19.

Materials And Methods: The article presents clinical and instrumental data of 1169 patients included in a single-center mixed study. Patients were tested for COVID-19 using polymerase chain reaction, computed tomography (CT), and antibody screening.

Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?

Regulated in Development and DNA Damage Response 1 (REDD1)/DNA Damage-Induced Transcript 4 (DDIT4) is an immediate early response gene activated by different stress conditions, including growth factor depletion, hypoxia, DNA damage, and stress hormones, i.e., glucocorticoids.

Influence of new phytoregulators on oilseed flax growth, development, yielding capacity, and product quality.

The use of phytoregulators is a modern way of producing crops to increase yields and product quality. The components of phytoregulators have a beneficial effect on the growth and development of plants and help to withstand unfavorable environmental factors, stress, lack of mineral nutrition, soil fatigue, and the action of a wide range of pesticides. The research is aimed to investigate the influence of three phytoregulators: Cherkaz, Floravit, EcoFus on two varieties of flax: Severny and LM 98.

Reductive Recyclization of sp-Enriched Functionalized Isoxazolines into α-Hydroxy Lactams.

An efficient synthesis (up to a 200 g scale) of 3-hydroxypyrrolidin-2-ones bearing alkyl substituents or functional groups at the C-5 position is described. The reaction sequence started from 1,3-dipolar cycloaddition of generated nitrile oxides with (meth-)acrylates into 3-substituted isoxazoline-5-carboxylates. The catalytic hydrogenolysis of the isoxazoline N-O bond was optimal upon using H (1 atm) at rt, with the following order of the catalyst activity: Pd-C > Pd(OH)-C > Pt-C.

Extracorporeal Photopheresis in Children with Chronic Graft-Versus-Host Disease.

Chronic graft versus host disease (cGVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). It significantly decreases survival and quality of life. The present study demonstrates retrospective data on extracorporeal photopheresis (ECP) in children with cGVHD.

Study of confounding factors influence on lung cancer diagnostics effectiveness using gas chromatography-mass spectrometry analysis of exhaled breath.

The purpose of this study was to estimate volatile organic compounds (VOCs) ability to distinguish exhaled breath samples of lung cancer patients and healthy volunteers and to assess the effect of smoking status and gender on parameters. Exhaled breath samples of 40 lung cancer patients and 40 healthy individuals were analyzed using gas chromatography-mass spectrometry. Influence of other factors on the exhaled breath VOCs profile was investigated.

Particulate Matter (PM) from Biomass Combustion Induces an Anti-Oxidative Response and Cancer Drug Resistance in Human Bronchial Epithelial BEAS-2B Cells.

Nearly half of the world's population relies on combustion of solid biofuels to cover fundamental energy demands. Epidemiologic data demonstrate that particularly long-term emissions adversely affect human health. However, pathological molecular mechanisms are insufficiently characterized.

Immune checkpoints bone marrow expression as the predictor of clinical outcome in myelodysplastic syndrome.

Aims: In our single-center retrospective study we evaluated whether level of different checkpoint molecules in bone marrow biopsies at diagnosis affect the clinical course of patients with myelodysplastic syndrome (MDS).

Methods And Results: A consecutive cohort of 55 MDS patients treated in our center from 2003 to 2018 with available bone marrow biopsies at time of diagnosis was studied. We used a technique able to detect the expression of the following antigens: PD-1, PD-L1, PD-L2, LAG-3, Gal-9, TIM-3, CD80.

Long-term outcomes of ruxolitinib therapy in steroid-refractory graft-versus-host disease in children and adults.

Acute and chronic steroid-refractory graft-versus-host disease (srGVHD) is a life-threatening complication of allogeneic stem cell transplantation. There are a number of reports on case series describing efficacy of ruxolitinib in both acute and chronic srGVHD. We conducted a prospective study (NCT02997280) in 75 patients with srGVHD (32 acute, 43 chronic, 41 adults, and 34 children).

[Rhinosinusitis in Hurler syndrome patients requiring hematopoietic stem cells transplantation].

Introduction: Allogenic transplantation of hemopoetic stem cells (allo-THSC) is one of the most effective treatment methods for Hurler syndrome, aimed at maximal correction of complications related to the genetic disorder. Presence of infection in the recipient is an adverse risk factor, affecting the possibility of starting the conditioning regimen and THSC peforming in general.

Aim: To assess the condition of the nasal cavity and paranasal sinuses in Hurler syndrome patients before the allo-THSC, dynamics of these changes after the transplantation taking into account the correction of alpha-L-iduronidase enzyme level with donor blood cells.

Stress fibers, autophagy and necrosis by persistent exposure to PM2.5 from biomass combustion.

Fine particulate matter (PM2.5) can adversely affect human health. Emissions from residential energy sources have the largest impact on premature mortality globally, but their pathological and molecular implications on cellular physiology are still elusive.

[Dynamics of duration of tracheal forced expiratory noises during long-term isolation in the "Mars-500" experiment].

Dynamics of duration of tracheal forced expiratory noises in a group of volunteers was studied before, during and after 520-days confinement. The duration did not change in most volunteers. Two volunteers demonstrated significant changes of tracheal sounds duration and some spirometric parameters.

[Influence of changed gas media on acoustic parameters of human forced exhalation].

In previous study it was shown that duration of tracheal forced expiratory noises is promising to reveal negative changes of lung function after dive. The objective is a study of parameters of tracheal forced expiratory noises in changed gas media. The first experiment involved 25 volunteers (22-60 years), performed forced exhalation under normal pressure with air, oxygen-helium and oxygen-krypton mixtures.

[Acoustic and spirometric indices of forced expiration noise in the conditions of 5-day dry immersion].

Dynamic studies of forced expiration (FE) indices involved 7 normal males aged 21 to 25 participating in a 5-d experiment with dry immersion (DI). FE spirometry was conducted simultaneously with registration of tracheal noise with the help of a microphone. Indices included acoustic duration of tracheal noise (Ta), forced lung capacity (FLC), FE volume per a second (FEV1), peak expiratory rate (PER) and time to reach (T(PER)) before DI, on DI days 1 and 4, and next day after completion.

Levels of follicular G-CSF and interleukin-15 appear as noninvasive biomarkers of subsequent successful birth in modified natural in vitro fertilization/intracytoplasmic sperm injection cycles.

Objective: To explore oocyte competence for subsequent birth. The modified natural IVF/intracytoplasmic sperm injection (ICSI) cycle was used as an experimental model by measuring levels of cytokines, chemokines, and growth factors in individual follicular fluids (FF).

Design: A retrospective blinded study.