Publications by authors named "Osia G Gideon"
Article Synopsis
- * Waltheriones A and C demonstrated noteworthy anti-HIV effects in lab tests, effectively protecting cells at certain concentrations and inhibiting HIV P24 formation by over 50%.
- * The structures of the identified alkaloids were confirmed using spectroscopic data analysis.
Two new triterpenoids were isolated from the leaves and twigs of Rhus taitensis. Their structures were elucidated by 1D and 2D NMR spectroscopic studies as 1,10,24,25,30-pentahydroxysqualene and dammar-20(22),24-diene-3 β,26,27-triol. Both compounds exhibited moderate antimycobacterial activities with an MIC of 45 µg/mL.
View Article and Find Full Text PDFTuberculosis has become a major health problem, in particular with the emergence of extremely drug resistant tuberculosis (XDRTB). In our search for new therapeutic leads against TB, we isolated a new triterpene (1) from the plant Rhus taitensis collected in Papua New Guinea. Tetrahydroxysqualene (1) was isolated using bioassay-guided fractionation of the methanolic extract of R.
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