Source localization using virtual magnetoencephalography helmets: A simulation study toward a prior-based tailored scheme.

Magnetoencephalography (MEG) source estimation of brain electromagnetic fields is an ill-posed problem. A virtual MEG helmet (VMH), can be constructed by recording in different head positions and then transforming the multiple head-MEG coordinates into one head frame (i.e.

Digital Semiology: A Prototype for Standardized, Computer-Based Semiologic Encoding of Seizures.

Video-EEG monitoring (VEM) is imperative in seizure classification and presurgical assessment of epilepsy patients. Analysis of VEM is currently performed in most institutions using a freeform report, a time-consuming process resulting in a non-standardized report, limiting the use of this essential diagnostic tool. Herein we present a pilot feasibility study of our experience with "Digital Semiology" (DS), a novel seizure encoding software.

Neuronal avalanches and time-frequency representations in stimulus-evoked activity.

Neuronal avalanches are a hallmark feature of critical dynamics in the brain. While the theoretical framework of a critical branching processes is generally accepted for describing avalanches during ongoing brain activity, there is a current debate about the corresponding dynamical description during stimulus-evoked activity. As the brain activity evoked by external stimuli considerably varies in magnitude across time, it is not clear whether the parameters that govern the neuronal avalanche analysis (a threshold or a temporal scale) should be adaptively altered to accommodate these changes.

Deviations from Critical Dynamics in Interictal Epileptiform Activity.

Unlabelled: The framework of criticality provides a unifying perspective on neuronal dynamics from in vitro cortical cultures to functioning human brains. Recent findings suggest that a healthy cortex displays critical dynamics, giving rise to scale-free spatiotemporal cascades of activity, termed neuronal avalanches. Pharmacological manipulations of the excitation-inhibition balance (EIB) in cortical cultures were previously shown to result in deviations from criticality and from the power law scaling of avalanche size distribution.

Near-Critical Dynamics in Stimulus-Evoked Activity of the Human Brain and Its Relation to Spontaneous Resting-State Activity.

Unlabelled: In recent years, numerous studies have found that the brain at resting state displays many features characteristic of a critical state. Here we examine whether stimulus-evoked activity can also be regarded as critical. Additionally, we investigate the relation between resting-state activity and stimulus-evoked activity from the perspective of criticality.

Brain response during the M170 time interval is sensitive to socially relevant information.

Deciphering the social meaning of facial displays is a highly complex neurological process. The M170, an event related field component of MEG recording, like its EEG counterpart N170, was repeatedly shown to be associated with structural encoding of faces. However, the scope of information encoded during the M170 time window is still being debated.

Folding of multidomain proteins: biophysical consequences of tethering even in apparently independent folding.

Most eukaryotic and a substantial fraction of prokaryotic proteins are composed of more than one domain. The tethering of these evolutionary, structural, and functional units raises, among others, questions regarding the folding process of conjugated domains. Studying the folding of multidomain proteins in silico enables one to identify and isolate the tethering-induced biophysical determinants that govern crosstalks generated between neighboring domains.