Publications by authors named "Oshini V Keerthisinghe"
Article Synopsis
- Nicotinic acetylcholine receptors (nAChRs) play important roles in brain functions and are linked to neurodegenerative disorders, with the α4β2* and α7 subtypes showing key differences in distribution across brain regions.
- Comparative studies in mouse and rat brains revealed α4β2* is more present in areas like the thalamus and subiculum, whereas α7 dominates the hippocampus.
- The development of KS7, a compound designed to target α7 and β2 subunits, shows varied binding affinities, suggesting that it may not effectively bind to the α7 subunit of the newly identified α7β2 nAChR subtype without further modification.
