Measurement of ophthalmodynamometric pressure with the vented-gas forced-infusion system during pars plana vitrectomy.

Purpose: To measure ophthalmodynamometric pressure (ODP) with the vented-gas forced-infusion (VGFI) system during vitrectomy in patients with various vitreoretinal disorders and to investigate factors related to ODP.

Methods: This study included 169 eyes of 169 patients undergoing pars plana vitrectomy. After core vitrectomy, the intraocular pressure was gradually raised by using the VGFI system.

Vision-related quality of life after transsphenoidal surgery for pituitary adenoma.

PURPOSE. To use the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) to evaluate vision-related quality of life (VR-QOL) in patients with pituitary adenoma who undergo transsphenoidal surgery. METHODS.

[Time course of changes in contrast sensitivity function after application of antiglaucomatous eyedrops].

Purpose: Some antiglaucomatous eyedrops can cause blurred vision after application. Contrast sensitivity after application, however, has not been examined. The purpose of this study was to investigate the influence of antiglaucomatous eyedrops on contrast sensitivity function.

Influence of induced decentered orthokeratology lens on ocular higher-order wavefront aberrations and contrast sensitivity function.

Purpose: To quantitatively evaluate the effect of overnight orthokeratology lenses intentionally left decentered after 3 months of wear and assess the influence on clinical outcomes such as ocular higher-order wavefront aberrations and contrast sensitivity function.

Setting: Department of Ophthalmology, Tsukuba University Hospital, Ibaraki, Japan.

Methods: This prospective study assessed refraction, visual acuity, corneal topography, wavefront aberration, and contrast sensitivity function before and 3 months after overnight orthokeratology treatment.

Time course of changes in ocular wavefront aberration after instillation of 0.5% timolol gel-forming solution.

Aims: To investigate the influence of 0.5% timolol gel-forming solution on ocular wavefront aberrations.

Methods: In 17 normal volunteers, ocular aberration was assessed before and 5 min, 30 min, 1 h, 2 h, 3 h, 6 h and 12 h after instillation of timolol gel-forming solution.

Vision-related quality of life and visual function after vitrectomy for various vitreoretinal disorders.

Purpose: To investigate vision-related quality of life (VR-QOL) in patients undergoing vitrectomy for various vitreoretinal disorders and to evaluate the relationship between VR-QOL and visual function.

Methods: The study included 100 normal control subjects and 299 patients with various vitreoretinal disorders including proliferative diabetic retinopathy (PDR), diabetic macular edema (DME), branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO), macular hole (MH), epiretinal membrane (ERM), and rhegmatogenous retinal detachment (RD). The 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) was answered by the patients with vitreoretinal disorders before and 3 months after pars plana vitrectomy, as well as by the normal control subjects.

Corneal sensation after overnight orthokeratology.

Purpose: The purpose of this study was to investigate the influence of overnight orthokeratology on corneal sensation.

Methods: A prospective study was conducted in 34 eyes of 17 patients undergoing overnight orthokeratology. Their ages ranged from 21 to 33 years (23.

Investigation of multifocal choroiditis with panuveitis by three-dimensional high-penetration optical coherence tomography.

A single case of multifocal choroiditis with panuveitis (MFCPU) was investigated by a three-dimensional (3-D) high-penetration optical coherence tomography. The HP-OCT is based on a swept-source OCT technology, uses a probe beam with a center wavelength of 1060 nm, and possesses a depth resolution of 10.4 micromin tissue.

Vision-related quality of life and visual function in patients undergoing vitrectomy, gas tamponade and cataract surgery for macular hole.

Aim: To evaluate the relationship between vision-related quality of life (VR-QOL) and visual function in patients undergoing vitrectomy, gas tamponade and cataract surgery for macular hole (MH).

Methods: The 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) was self-administered by 32 patients with MH (age 66.2 (SD 5.

Experimental use of estriol for visualizing the vitreous body in the anterior chamber after posterior capsule rupture in animal models.

Purpose: To compare the efficacy and safety of estriol and triamcinolone acetonide suspensions in visualizing the prolapsed vitreous body in the anterior chamber after posterior capsule rupture in animal models.

Setting: Tsukuba University Institute of Clinical Medicine, Ibaraki, Japan.

Methods: To evaluate efficacy, triamcinolone acetonide or estriol suspension was injected into the anterior chambers of porcine eyes after intentional posterior capsule rupture.

Patient satisfaction and clinical outcomes after overnight orthokeratology.

Purpose: To assess patient satisfaction following overnight orthokeratology using a visual analogue scale and to find clinical factors that influence patient satisfaction.

Methods: In this prospective study, subjective patient satisfaction with visual outcomes was measured using a visual analogue scale, ranging from 0 (very dissatisfied) to 10 (very satisfied) in 17 patients who completed 1-year follow-up examinations after commencement of orthokeratology. Spherical equivalent refraction at baseline was 2.

Postural response of intraocular pressure and visual field damage in patients with untreated normal-tension glaucoma.

Purpose: To evaluate whether postural changes of intraocular pressure (IOP) are associated with visual field damage by comparing both eyes of patients with previously untreated normal-tension glaucoma (NTG).

Patients And Methods: Forty eyes of 20 patients newly diagnosed as bilateral NTG were studied. IOP was measured in both sitting and supine positions, and the magnitude of IOP elevation with postural change (ΔIOP) was calculated.

Mesopic contrast sensitivity and ocular higher-order aberrations in eyes with conventional spherical intraocular lenses.

Purpose: To investigate relationship between mesopic contrast sensitivity (CS) function and ocular higher-order aberrations in eyes implanted with conventional spherical intraocular lenses (IOL).

Design: Prospective, nonrandomized case series.

Methods: Sixty-eight eyes of 48 patients who attained best spectacle-corrected visual acuity (BSCVA) of 20/20 or better after phacoemulsification and spherical IOL implantation were included in the study.

Intraindividual comparison of aspherical and spherical intraocular lenses of same material and platform.

Purpose: There have been few studies which compared aspherical and spherical intraocular lenses (IOLs) of same material and platform in bilateral cataract cases. We performed an intraindividual comparison of ocular aberration and scotopic, mesopic, and photopic contrast sensitivity with aspherical and spherical IOLs, using the same IOL material and platform manufactured by the same company.

Design: Prospective, randomized, controlled study.

Anterior ocular biometry using 3-dimensional optical coherence tomography.

Purpose: To evaluate anterior ocular biometry by comparing the measurements of central corneal thickness (CCT) and anterior chamber depth (ACD) with 3-dimensional corneal and anterior segment optical coherence tomography (CAS-OCT) and other methods.

Design: Cross-sectional study.

Participants: Forty eyes of 40 normal subjects.

SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy.

Aim: Neovascularization is an important event in proliferative diabetic retinopathy (PDR), where various secretory proteins including multiple growth factors are considered to be involved in this process. We searched for secretory proteins expressed in a surgical specimen obtained from the eyes of patients with PDR.

Methods: We developed the oligo-cap signal sequence trap (SST) strategy which enables us to screen for secretory or membrane proteins from a minimal starting material.

One-year prospective intrapatient comparison of aspherical and spherical intraocular lenses in patients with bilateral cataract.

Purpose: To conduct longitudinal, intrapatient comparisons of aspherical and spherical silicone intraocular lenses (IOL) of the same material and platform in patients undergoing bilateral cataract surgery.

Design: Prospective, randomized study.

Methods: Sixty-two eyes of 31 patients were randomized to receive a silicone aspherical IOL (Tecnis Z9000; AMO Inc, Santa Ana, California, USA) in 1 eye and a silicone spherical IOL (CeeOn 911A; AMO Inc) in the other eye.

Immunohistochemical localisation of D-beta-aspartic acid-containing proteins in climatic droplet keratopathy.

Aim: Biologically uncommon D-beta-aspartic acid (D-beta-Asp) accumulates in the body with age and is involved in the ageing process. In the present study, the localisation of D-beta-Asp-containing proteins was investigated in surgical specimens with climatic droplet keratopathy (CDK), one of the ocular changes related to the ageing process.

Methods: Immunohistochemical localisation of D-beta-Asp-containing proteins using polyclonal antibodies raised against D-beta-Asp-containing peptides was examined in three corneas with CDK, three corneas with interstitial keratitis, six corneas with bullous keratopathy, and three corneas without any corneal diseases.

Immunohistochemical localisation of D-beta-aspartic acid in pingueculae.

Background: D-beta-aspartic acid residues, which are biologically uncommon, have been reported to accumulate in various proteins of the living body with age. In the present study, D-beta-aspartic acid-containing proteins were found to be localised in pingueculae, which represent one of the most prominent age-related ocular changes.

Methods: Surgical specimens of conjunctivae with or without pingueculae were obtained from eight patients.

Evaluation of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography.

Objective: To investigate the internal structures of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography (3-D CAS OCT).

Design: Observational case series.

Participants: Thirty-eight filtering blebs in 31 patients who had undergone trabeculectomy examined retrospectively.

Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography.

A sequential case series of post-glaucoma-surgery structures examined by three-dimensional corneal and anterior eye segment optical coherence tomography (3D-CASOCT) and 3D polarization sensitive CASOCT (PS-CASOCT) is presented. A total of 5 patients who underwent glaucoma surgery were included in this study. Of these, 1, 1, and 3 patient underwent trabeculotomy, laser iridotomy, and trabeculectomy respectively.

A case of subperiosteal abscess of the orbit with central retinal artery occlusion.

Purpose: To report a rare case of orbital subperiosteal abscess with central retinal artery occlusion that resulted in blindness.

Methods: A 60-year-old previously healthy woman was referred to the hospital with 4-day history of orbital cellulitis, progressive left eye pain, eyelid swelling, and 1-day history of visual impairment. The patient was diagnosed with subperiosteal abscess of the orbit on diagnostic imaging.

Effect of vitrectomy for epiretinal membrane on visual function and vision-related quality of life.

Purpose: To evaluate the vision-related quality of life (VR-QOL) in patients undergoing vitrectomy for epiretinal membrane (ERM) removal and to investigate the relationship between VR-QOL and the severity of pre/postoperative metamorphopsia.

Design: Prospective, interventional, consecutive, comparative case series.

Methods: The 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was self-administered by 28 patients (age, 66.

Increased level of (1,3)-beta-D-glucan in tear fluid of mycotic keratitis.

Purpose: Increased concentration of (1,3)-beta-D-glucan, one of the major components of fungal cell walls, is detected in the serum of systemic fungal infection. In our study, the concentration of (1,3)-beta-D-glucan was measured in the tear fluid of patients with mycotic keratitis.

Methods: Tear fluid was collected from patients with fungal keratitis (n = 4) and bacterial corneal ulcers (n = 4) with or without corneal scraping.

Toxicities and pharmacokinetics of subconjunctival injection of liposomal amphotericin B.

Introduction: The toxicity of conventional formulations of amphotericin B deoxycholate (AmB(DOC)) limits its clinical applications. To reduce the toxicity of AmB(DOC), lipid formulations of amphotericin B (AmB) have been developed and clinically applied. In the present study, we evaluated the ocular toxicity and pharmacokinetics of subconjunctival injection of liposomal AmB.