Investigating the Roles of Active Site Residues in Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents.

drug resistance is emerging and new drug targets are needed. Tryptophan biosynthesis is necessary for replication and virulence. Indole-3-glycerol phosphate synthase (IGPS) catalyzes a step in tryptophan biosynthesis and has been suggested as a potential anti-infective target, but our understanding of this enzyme is limited.