Limits to sustained energy intake. XXVII. Trade-offs between first and second litters in lactating mice support the ecological context hypothesis.

Increased reproductive effort may lead to trade-offs with future performance and impact offspring, thereby influencing optimal current effort level. We experimentally enlarged or reduced litter size in mice during their first lactation, and then followed them through a successive unmanipulated lactation. Measurements of food intake, body mass, milk energy output (MEO), litter size and litter mass were taken.

Limits to sustained energy intake. XVII. Lactation performance in MF1 mice is not programmed by fetal number during pregnancy.

Several studies have suggested that lactation performance may be programmed by the number of fetuses during pregnancy, whereas other studies indicate that processes during lactation are more important. As gestation litter size and litter size in lactation are usually strongly correlated, separating the roles of pregnancy and lactation in lactation performance is difficult. To break this link, we experimentally manipulated litter size of MF1 mice to five or 16 pups per litter by cross-fostering.