Supplementation of n3 long-chain polyunsaturated fatty acid synergistically decreases insulin resistance with weight loss of obese prepubertal and pubertal children.

Background And Aims: Supplementation with n3 long-chain polyunsaturated fatty acids (n3-LCPUFA) appears to affect body weight, adipokines, and insulin resistance (IR) in obese individuals. However, it is unclear whether the effect on IR is independent of weight loss and if the same effect is observed in children. We undertook this study to analyze the effect of supplementation with n3-LCPUFA on adipokine concentration and IR of prepubertal and pubertal children, independent of weight loss.