Publications by authors named "Oscar Sapkota"
Article Synopsis
- NM1 is a crucial regulator of cellular metabolism, influencing mitochondrial function and oxidative phosphorylation by affecting key transcription factors.
- Deletion of NM1 leads to underdeveloped mitochondria and changes in cellular dynamics, resulting in a shift from oxidative phosphorylation to aerobic glycolysis, which is commonly seen in cancer cells.
- This metabolic switch, characterized by increased metabolism of amino acids, fatty acids, and sugars, supports tumor formation in NM1 knockout (KO) cells, indicating NM1's role as a potential tumor suppressor.
