Publications by authors named "Oscar Orlando Araya Fernandez"
Background: The effects of topical application of sucralfate (SCF) on the tissue content of MUC-2 protein have not yet been evaluated in experimental models of diversion colitis.
Aim: To measure the tissue content of MUC-2 protein in the colonic mucosa diverted from fecal stream submitted to the SCF intervention.
Methods: Thirty-six rats underwent derivation of intestinal transit through proximal colostomy and distal mucous fistula.
Article Synopsis
- The study investigates the effects of sucralfate (SCF) enemas on MUC-2 protein levels in the colonic mucosa of rats with diversion colitis.
- Rats were divided into groups receiving different SCF concentrations and treatment durations. Results indicated that SCF, especially at 2 g/kg/day, significantly reduced inflammation and increased MUC-2 levels compared to saline treatment.
- The findings suggest that SCF could be an effective therapeutic method to manage inflammation and maintain MUC-2 levels in the colon after diversion.