Publications by authors named "Oscar Matteo Gagliardi"
Article Synopsis
- Proliferative vitreoretinopathy (PVR) causes fibrotic membranes that lead to recurrent retinal detachment, with current treatment (pars plana vitrectomy) having high recurrence rates due to unresolved underlying issues.
- There are no approved pharmacological therapies for PVR, largely because of ethical and safety concerns in preclinical and in vivo studies.
- The review discusses the potential of computational models and Digital Twins in developing personalized treatment strategies, highlighting nintedanib as a promising drug candidate for simulating effects on fibrotic pathways.
The polymorphism of the HLA system has been extensively studied in COVID-19 infection, however there are no data about the role of HLA on vaccine response. We report here the HLA-A, -B, -C, and DRB1 allelic frequencies of n = 111 individuals after BNT162b2 mRNA vaccine, selected on the basis of lower antibody levels (<5% percentile) after the second dose among a total of n = 2569 vaccinees, and compare them with the frequencies of a reference population. We found that differences in the frequencies of the alleles HLA-A*03:01, A*33:03, B*58:01 and at least one haplotype (HLA-A*24:02~C*07:01~B*18:01~DRB1*11:04) are associated with a weaker antibody response after vaccination, together with the age of vaccinees.
View Article and Find Full Text PDFObjective: To evaluate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) anti-spike (S) IgG antibody production after vaccination with BNT162b2 and the protection from symptomatic breakthrough infections in health care workers.
Methods: This prospective observational study (RENAISSANCE) had as a primary end point the evaluation of serologic response to BNT162b2 14 days after a second dose. SARS-CoV-2 anti-S IgG antibodies were evaluated with LIAISON SARS-CoV-2 TrimericS IgG assay (DiaSorin S.