Publications by authors named "Oscar Fogelberg"
Effects-directed analysis of sediments from polluted marine sites in Norway.
J Toxicol Environ Health A
May 2011
Article Synopsis
- The study examined the pollution levels of two marine sites in Norway, Grenland and Oslo harbor, using target chemical analysis and effect-directed analysis (EDA).
- High concentrations of harmful substances like metals, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) were found at these sites, with Oslo harbor displaying elevated levels of organotin compounds.
- The investigation used the CALUX assay to measure aryl hydrocarbon receptor (AhR) activity, revealing the highest activity in Grenland due to historical dioxin releases, while different fractions of sediment indicated varying compounds contributing to this activity at both sites.
Alkylphenols act as estrogen mimics by binding to and transactivating estrogen receptors (ERs) in fish. In the present study, activation of ER-mediated production of the estrogenic biomarker vitellogenin (vtg) in a primary culture of rainbow trout (Oncorhynchus mykiss) hepatocytes was used to construct a structure-activity relationship for this ubiquitous group of aquatic pollutants. The role of alkyl chain length and branching, substituent position, number of alkylated groups, and the requirement of a phenolic ring structure was assessed.
View Article and Find Full Text PDFThe gill filament 7-ethoxyresorufin O-deethylase (EROD) assay was evaluated as a monitoring tool for waterborne cytochrome P4501A (CYP1A) inducers using rainbow trout (Oncorhynchus mykiss) caged in urban area waters in Sweden. To compare the CYP1A induction response in different tissues, EROD activity was also analyzed in liver and kidney microsomes. Immunohistochemistry was used to localize CYP1A protein in gill and kidney.
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