Publications by authors named "Oscar Esparcia Rodriguez"
Article Synopsis
- In June 2021, the WHO released a comprehensive catalogue of mutations in Mycobacterium tuberculosis that are linked to drug resistance, prompting researchers to evaluate its effectiveness for diagnosing drug-resistant tuberculosis in the relatively low prevalence area of Valencia, Spain.
- A retrospective genomic study analyzed 785 tuberculosis isolates collected between 2014-2016, utilizing whole-genome sequencing (WGS) to predict resistance profiles based on the catalogue and comparing these predictions with actual phenotypic results.
- The study found that while sensitivity for predicting resistance varied, with the highest at 85.4% for isoniazid, overall pan-susceptibility accuracy was 96.4%, highlighting some discrepancies in certain isolates that carried mutations known to cause borderline
Transmission is a driver of tuberculosis (TB) epidemics in high-burden regions, with assumed negligible impact in low-burden areas. However, we still lack a full characterization of transmission dynamics in settings with similar and different burdens. Genomic epidemiology can greatly help to quantify transmission, but the lack of whole genome sequencing population-based studies has hampered its application.
View Article and Find Full Text PDFObjective: Patients with Inflammatory Bowel Disease (IBD) are at increased risk of hepatitis B virus (HBV) infection as well as a lower response to vaccination. This study aimed to analyze the immune response after vaccination against HBV in patients diagnosed with IBD and its associated factors.
Methods: A retrospective observational study was conducted on patients with IBD treated at the vaccination clinic for at-risk patients at the during the period 2011-2018.
Objective: Ocular infections caused by human adenovirus are highly contagious and can cause outbreaks, especially in nursing homes. In this work, we describe the epidemiological and analytical research as well as the control measures carried out for a conjunctivitis outbreak.
Methods: Descriptive epidemiological study.
Background: Whole genome sequencing provides better delineation of transmission clusters in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal individual transmission links within clusters is limited. Here, we used a 2-step approach based on Bayesian transmission reconstruction to (1) identify likely index and missing cases, (2) determine risk factors associated with transmitters, and (3) estimate when transmission happened.
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