Publications by authors named "Oscar Enrique Torres Montaguth"
Article Synopsis
- * The study compared two sequencing approaches: untargeted metagenomics using Illumina and Oxford Nanopore Technologies (ONT), and a targeted panel approach with Twist Bioscience's Comprehensive Viral Research Panel (CVRP).
- * Results showed that the CVRP significantly improved detection sensitivity for low viral loads, while ONT performed well at high viral loads but required longer runs at lower viral loads; ONT also had better specificity compared to Illumina.
Article Synopsis
- Over 1,000 unexplained pediatric hepatitis cases have been identified globally, with a study focusing on 38 cases and various control groups to understand potential viral causes.
- High levels of adeno-associated virus 2 (AAV2) DNA were found in most cases, while low levels of adenovirus and human herpesvirus 6B were also detected; however, AAV2 appeared infrequently in healthy controls even when they were immunocompromised.
- The study suggests that abnormal replication of AAV2, potentially influenced by other viruses like HAdV and HHV-6B, may be responsible for immune-related liver disease in susceptible children.
Despite our extensive knowledge of the genetic regulation of heat shock proteins (HSPs), the evolutionary routes that allow bacteria to adaptively tune their HSP levels and corresponding proteostatic robustness have been explored less. In this report, directed evolution experiments using the Escherichia coli model system unexpectedly revealed that seemingly random single mutations in its gene can confer significant heat resistance. Closer examination, however, indicated that these mutations create folding-deficient and aggregation-prone TnaA variants that in turn can endogenously and preemptively trigger HSP expression to cause heat resistance.
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