Publications by authors named "Oscar Badillo"
Dendritic cells (DCs) possess a specialized function in presenting antigens and play pivotal roles in both innate and adaptive immune responses. Their ability to cross-present antigens from tumor cells to naïve T cells is instrumental in generating specific T-cell-mediated antitumor responses, crucial for controlling tumor growth and preventing tumor cell dissemination. However, within a tumor immune microenvironment (TIME), the functions of DCs can be significantly compromised.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates why glioblastoma (GBM) is often resistant to immune checkpoint inhibitors (ICIs) by examining the differences in tumor immune microenvironments (TIME) between GBM and other cancer types, focusing on the effects of tumor location (intracerebral vs. subcutaneous).
- - Results indicated that ICI responsiveness is linked to the presence of more T cells and dendritic cells (DCs) and fewer PD-L1+ macrophages; the SB28 GBM model only responded to ICIs when grown outside the brain, revealing the influence of the tumor environment on immune response.
- - The findings highlight that ineffective antigen presentation in the brain is a key challenge for GBM immunotherapy, suggesting that