Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening.

Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms.

Alpha-glucosidase inhibitor use is associated with decreased colorectal neoplasia risk in patients with type 2 diabetes mellitus receiving colonoscopy: a retrospective study.

Purpose: The purpose of this study was to clarify the factors that influence the incidence of colorectal neoplasia in patients with type 2 diabetes mellitus (DM).

Study Design And Setting: Among a total of 1176 patients who underwent total colonoscopy at our hospital, we retrospectively analyzed 168 patients with type 2 DM. Univariate and multivariate logistic regression analyses were then performed to identify the risk factors associated with colorectal neoplasia.

Characterization of the one-electron oxidized Cu(II)-salen complexes with a side chain aromatic ring: the effect of the indole ring on the Cu(II)-phenoxyl radical species.

To gain insights into the role of the proximal indole ring in the redox-active metal center as seen in galactose oxidase, we prepared the Cu(II)-salen-type complexes having a pendent indol-3-ylmethyl (1), methyl (2) or benzyl (3) group substituted on the ethylenediamine moiety and investigated the structures and redox properties by various physicochemical methods and theoretical calculations. Neutral complexes 1, 2, and 3 showed no significant difference in the UV-Vis-NIR and EPR spectra. One-electron oxidation of 1, 2, and 3 by addition of 1 equiv.

[A refractory duodenal ulcer with a biliary-duodenal fistula following the administration of bevacizumab].

A 65-year-old woman with recurrent breast cancer was repeatedly treated with bevacizumab, an anti-VEGF antibody. In addition, she was also frequently prescribed a nonsteroidal anti-inflammatory drug for abdominal pain. Melena was revealed 2 months after the final treatment with bevacizumab, and an endoscopic study revealed a duodenal ulcer (DU) that was resistant to anti-ulcer therapy.

Development of a Novel Scoring System for Predicting the Risk of Colorectal Neoplasia: A Retrospective Study.

Objective: The purpose of this study was to develop a novel scoring system to screen subjects who have a high risk for colorectal neoplasia.

Study Design And Setting: We retrospectively analyzed 1061 subjects undergoing total colonoscopy (TCS) for the first time at Gihoku Kosei Hospital. The characteristics and habits of the subjects were analyzed using a multivariate logistic regression analysis.

[Bile duct injury and severe bleeding after endoscopic papillary large balloon dilation without sphincterotomy: a case report].

We report the case of an 80-year-old woman with multiple choledocholithiasis who suffered severe bleeding after endoscopic papillary large balloon dilation (EPLBD). Astriction by balloon tamponade and a covered, self-expandable, metallic stent failed. However, embolization using a transcatheter arterial coil stopped the bleeding.

Properties of the indole ring in metal complexes. A comparison with the phenol ring.

Tryptophan (Trp), an essential amino acid, has an indole ring with a high electron density and is frequently seen at the proximal position of the metal site in metalloproteins. For example, the indole ring of Trp has been reported to interact weakly with Cu(I) in a Cu chaperone CusF. Another aromatic amino acid, tyrosine (Tyr), has a phenol ring, which is an important metal binding site in various metalloproteins.

[Delayed stenosis of the small intestine after cardiopulmonary arrest].

A man in his 70s experienced cardiopulmonary arrest (CPA) due to acute myocardial infarction. He was resuscitated and treated with a multimodal approach, and he fortunately survived CPA without neurological damage. However, abdominal pain and vomiting occurred 45 days after the CPA.

[A case of advanced gastric cancer with liver abscesses].

A man visited to our hospital because of high grade fever. Computed tomography revealed multilocular space occupying lesion which were suspected liver abscess. Upper gastrointestinal endoscopy showed an advanced gastric cancer with an ulcer on antrum.

Group-10 metal complexes of biological molecules and related ligands: structural and functional properties.

The complexes of group-10 metals, Ni, Pd, and Pt, with biological molecules and related ligands have been attracting increasing attention in recent years due to their reactivities and functions, such as catalysts and drugs, and their biological relevance. The well-defined structures and kinetic inertness especially of Pt complexes have been used as the sites for weak interactions with other molecules. The Ni complexes have been reported as models not only for Ni enzymes but also for other metalloenzyme active sites for deeper understanding of the reactivities such as oxygen activations and detailed electronic structures.

Metal complexes of amino acids and amino acid side chain groups. Structures and properties.

Alpha-amino acid residues exhibit various functions in biological systems. The side chain groups are very important for formation of the metal center and its catalytic action in proteins. They are involved in metal binding, molecular recognition by weak interactions, enzyme catalysis, and formation of the molecular environment.

CH...Metal(II) axial interaction in planar complexes (metal=Cu, Pd) and implications for possible environmental effects of alkyl groups at biological copper sites.

Intramolecular M(II)...

Formation and characterization of Co(III)-semiquinonate phenoxyl radical species.

Co(III) complexes of N(3)O-donor tripodal ligands, 2,4-di(tert-butyl)-6-{[bis(2-pyridyl)methyl]aminomethyl}phenolate (tbuL), 2,4-di(tert-butyl)-6-{[bis(6-methyl-2-pyridyl)methyl]aminomethyl}phenolate (tbuL(Mepy)(2)), were prepared, and precursor Co(II) complexes, [Co(tbuL)Cl] (1) and [Co(tbuL(Mepy)(2))Cl] (2), and ternary Co(III) complexes, [Co(tbuL)(acac)]ClO(4) (3), [Co(tbuL)(tbu-cat)] (4), and [Co(tbuL(Mepy)(2))(tbu-SQ)]ClO(4) (5), where acac, tbu-cat, and tbu-SQ refer to pentane-2,4-dionate, 3,5-di(tert-butyl)catecholate, and 3,5-di(tert-butyl)semiquinonate, respectively, were structurally characterized by the X-ray diffraction method. Complexes 3 and 5 have a mononuclear structure with a fac-N(3)O(3) donor set, while 4 has a mer-N(3)O(3) structure. The cyclic voltammogram (CV) of complex 3 exhibited one reversible redox wave centered at 0.

Syntheses and electronic structures of one-electron-oxidized group 10 metal(II)-(disalicylidene)diamine complexes (metal = Ni, Pd, Pt).

Group 10 metal(II) complexes of H2tbu-salen (H2tbu-salen = N,N'-bis(3',5'-di-tert-butylsalicylidene)ethylenediamine) and H2tbu-salcn (H2tbu-salcn = N,N'-bis(3',5'-di-tert-butylsalicylidene)-1,2-cyclohexanediamine) containing two 2,4-di(tert-butyl)phenol moieties, [Ni(tbu-salen)] (1a), [Ni(tbu-salcn)] (1b), [Pd(tbu-salen)] (2a), [Pd(tbu-salcn)] (2b), and [Pt(tbu-salen)] (3), were prepared and structurally characterized by X-ray diffraction, and the electronic structures of their one-electron-oxidized species were established by spectroscopic and electrochemical methods. All the complexes have a mononuclear structure with two phenolate oxygens coordinated in a very similar square-planar geometry. These complexes exhibited similar absorption spectra in CH2Cl2, indicating that they all have a similar structure in solution.

Pi-pi stacking assisted binding of aromatic amino acids by copper(II)-aromatic diimine complexes. Effects of ring substituents on ternary complex stability.

Ternary Cu(ii) complexes containing an aromatic diimine (DA = di(2-pyridylmethyl)amine (dpa), 4,4'-disubstituted 2,2'-bipyridine (Y(2)bpy; Y = H (bpy), Me, Cl, N(Et)(2), CONH(2) or COOEt) or 2,2'-bipyrimidine) and an aromatic amino acid (AA = l-phenylalanine (Phe), p-substituted phenylalanine (XPhe; X = NH(2), NO(2), F, Cl or Br), l-tyrosine (Tyr), l-tryptophan (Trp) or l-alanine (Ala)) were characterized by X-ray diffraction, spectroscopic and potentiometric measurements. The structures of [Cu(dpa)(Trp)]ClO(4).2H(2)O and [Cu((CONH(2))(2)bpy)(Phe)]ClO(4).

Indole rings in palladium(II) complexes. Dual mode of metal binding and aromatic ring stacking causing syn-anti isomerism.

In view of the interesting metal-binding properties of lichen substances and the indole ring as a potential ligand, we studied the Pd(II) complexes of indole-containing ligands, N-(indole-3-ethyl)-Delta(2,11)-enaminousnic acid (IEU) and 4-[2-(indol-3-yl)-ethylamino]pent-3-en-2-one (IEP) obtained by condensation of tryptamine with usnic acid and its model acetylacetone, respectively. Reactions of Pd(II) with IEU and IEP gave isomeric complexes resulting from coordination of the C3 atom of the indole ring in the 3H-indole form, Pd2(IEUH(-2))(2) (1 and 2) and Pd2(IEPH(-2))(2) (3 and 4) (IEUH(-2) and IEPH(-2) denote doubly deprotonated forms of IEU and IEP, respectively). Complexes 1-4 were determined, from the NMR and MS spectra, to have dimeric structures doubly bridged by the indole rings, which were stacked in different orientations.

Dipolar ruthenium(II) ammine complexes as electron transfer mediators of amperometric glucose sensors.

The mediation of dipolar ruthenium(II) ammine complexes containing pyridinium ions [Ru(NH(3))(5)(L(+))](3+)(L(+): pyridinium ions) in glucose oxidation has been investigated by a voltammetric method. These ruthenium(II) complexes had appropriate redox potentials of 0.10-0.

Cyclopalladation of the indole ring in palladium(II) complexes of 2N1O-donor ligands and its dependence on the O-donor properties.

Synthetic, structural, spectroscopic, and kinetic studies have been carried out on the Pd(II) complexes of new 2N1O-donor ligands containing a pendent indole, 3-(N-2-pyridylmethyl-N-2-hydroxy-5-methoxybenzylamino)ethylindole (HMeO-iepp), 3-(N-2-pyridylmethyl-N-2-hydroxy-5-nitrobenzylamino)ethylindole (HNO2-iepp), and (N-2-pyridylmethyl-3-indolylethylamino)acetic acid (Hiepc) (H denotes a dissociable proton). [Pd(MeO-iepp)Cl] (2), [Pd(NO2-iepp)Cl] (3), and [Pd(iepc)Cl] (4) were prepared and revealed by X-ray analysis to have a pyridine nitrogen, an amine nitrogen, a phenolate or carboxylate oxygen, and a chloride ion in the coordination plane. UV absorption and 1H NMR spectral changes indicated that all the complexes could be converted to the indole-binding complexes where the O donor was replaced by the indole C2 atom by cyclopalladation in DMSO or DMF in the temperature range of 40-60 degrees C.

Nickel(II)-phenoxyl radical complexes: structure-radical stability relationship.

Nickel(II) complexes of N3O-donor tripodal ligands, 2,4-di-tert-butyl-6-[([bis(2-pyridyl)methyl]amino)methyl]phenol (HtbuL), 2,4-di-tert-butyl-6-[([(6-methyl-2-pyridyl)methyl](2-pyridylmethyl)amino)methyl]phenol (HtbuLMepy), and 2,4-di-tert-butyl-6-[([bis(6-methyl-2-pyridyl)methyl]amino)methyl]phenol (HtbuL(Mepy)2), were prepared, and [Ni(tbuL)Cl(H2O)] (1), [Ni(tbuLMepy)Cl] (2), and [Ni(tbuL(Mepy)2)Cl] (3) were structurally characterized by the X-ray diffraction method. Complexes 1 and 3 have a mononuclear structure with a coordinated phenolate moiety, while 2 has a dinuclear structure bridged by two chloride ions. The geometry of the Ni(II) center was found to be octahedral for 1 and 2 and 5-coordinate trigonal bipyramidal for 3.

Reactivity of the indole ring in palladium(II) complexes of 2N1O-donor ligands: cyclopalladation and pi-cation radical formation.

The Pd(II) complexes of new 2N1O-donor ligands containing a pendent indole, 3-[N-2-pyridylmethyl-N-2-hydroxy-3,5-di(tert-butyl)benzylamino]ethylindole (Htbu-iepp), 1-methyl-3-[N-2-pyridylmethyl-N-2-hydroxy-3,5-di(tert-butyl)benzylamino]ethylindole (Htbu-miepp), 3-[N-2-pyridylmethyl-N-2-hydroxy-3,5-di(tert-butyl)benzylamino]methylindole (Htbu-impp), and 3-(N-2-pyridylmethyl-N-4-hydroxybenzylamino)ethylindole (Hp-iepp) (H denotes a dissociable proton), were synthesized, and the structures of [Pd(tbu-iepp)Cl] (1a), [Pd(tbu-iepp-c)Cl] (1b), [Pd(tbu-miepp)Cl] (3), and [Pd(p-iepp-c)Cl] (4) (tbu-iepp-c and p-iepp-c denote tbu-iepp and p-iepp bound to Pd(II) through a carbon atom, respectively) were determined by X-ray analysis. Complexes 1a prepared in CH(2)Cl(2)/CH(3)CN and 3 prepared in CH(3)CN have a pyridine nitrogen, an amine nitrogen, a phenolate oxygen, and a chloride ion in the coordination plane. Complex 1b prepared in CH(3)CN has the same composition as 1a and was revealed to have the C2 atom of the indole ring bound to Pd(II) with the Pd(II)-C2 distance of 1.

One-electron oxidized nickel(II)-(disalicylidene)diamine complex: temperature-dependent tautomerism between Ni(III)-phenolate and Ni(II)-phenoxyl radical states.

The one-electron oxidized species of a Ni(II)-phenolate complex has been shown to be in the Ni(II)-phenoxyl radical state at room temperature and the Ni(III)-phenolate state at < -120 degrees C, indicating that the oxidation state is temperature dependent.

Combined effects of electrostatic and pi-pi stacking interactions: selective binding of nucleotides and aromatic carboxylates by platinum(II)-aromatic ligand complexes.

Adduct formations of Pt(II) complexes containing an aromatic diimine (DA) and an L-amino acid (A) with an aromatic carboxylate (AR) or a mononucleotide (NMP) has been studied by synthetic, structural, spectroscopic, and calorimetric methods. Several adducts between Pt(II) complexes, [Pt(DA)(L-A)] (charges are omitted; DA=2,2'-bipyrimidine (bpm); A=L-arginine (L-Arg), L-alaninate (L-Ala), and AR (=indole-3-acetate (IA), gentisate (GA)) or GMP were isolated as crystals and structurally characterized by the X-ray diffraction method. GMP in [Pt(bpm)(Arg)](GMP).