Diagnostic Performance and Safety of Positron Emission Tomography Using F-Fluciclovine in Patients with Clinically Suspected High- or Low-grade Gliomas: A Multicenter Phase IIb Trial.

Objectives: The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer F-fluciclovine (anti-[F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.

Methods: Anti-[F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET imaging. T1-weighted, contrast-enhanced T1-weighted, and fluid-attenuated inversion recovery (or T2-weighted) magnetic resonance imaging (MRI) scans were obtained to plan for the tissue collection.

Multiple dural arteriovenous fistulas causing rapid progressive dementia successfully treated by endovascular surgery: case report.

A 67-year-old female presented with multiple dural arteriovenous fistulas (AVFs) manifesting as dementia rapidly progressing over 2 months. The initial diagnosis was Creutzfeldt-Jakob disease based on the acute clinical course. However, angiography eventually revealed multiple dural AVFs involving the bilateral convexities to the superior sagittal sinus and the right transverse-sigmoid sinus.

Effect of C-type natriuretic peptide (CNP) on water channel aquaporin-4 (AQP4) expression in cultured astrocytes.

Astrocytes play a vital role in volume and ion control in the central nervous system. C-type natriuretic peptide (CNP) may be involved in neuronal-glial signaling, but its physiological role has not yet been characterized. In our study, we found that CNP can regulate the water channel aquaporin-4 (AQP4) expression in cultured astrocytes.