Publications by authors named "Osamu Nose"
Article Synopsis
- About twice as many boys as girls receive growth hormone therapy for growth hormone deficiency (GHD), but this may be due to a selection bias rather than actual prevalence.
- A study involving 3,902 children at 17 short stature clinics found no significant difference in the percentage of boys (45.7%) and girls (49.8%) undergoing GH stimulation tests, nor in the diagnosis rates of GHD (22.0% for boys vs. 20.1% for girls).
- The observed boy-to-girl ratio in both short stature and GHD diagnoses was similar (1.58:1 and 1.59:1 respectively), suggesting that more boys seek treatment due to parental concerns about boys' height
Background: Polymorphisms in the growth hormone receptor (GHR) gene were reported in Caucasian populations. However, the frequency of those in other ethnic backgrounds remains unclear.
Aim: We investigated the presence of polymorphisms in the GHR gene in a Japanese population and compared the frequencies with those reported in Caucasian populations.
Congenital combined pituitary hormone deficiency attributable to a novel PROP1 mutation (467insT).
J Pediatr Endocrinol Metab
April 2006
Background: Combined pituitary hormone deficiency (CPHD) is an anterior pituitary disorder, commonly resulting in growth retardation. PROP1 gene mutations appear to be frequently responsible for CPHD, particularly in Middle and Eastern Europe and the Americas, but few cases have been reported in Japan.
Patients And Design: Two sisters (aged 8.