Arrhythmic Risk Profile and Outcomes of Patients Undergoing Cardiac Sympathetic Denervation for Recurrent Monomorphic Ventricular Tachycardia After Ablation.

Background Cardiac sympathetic denervation (CSD) has been used as a bailout strategy for refractory ventricular tachycardia (VT). Risk of VT recurrence in patients with scar-related monomorphic VT referred for CSD and the extent to which CSD can modify this risk is unknown. We aimed to quantify arrhythmia recurrence risk and impact of CSD in this population.

Non-invasive stereotactic body radiation therapy for refractory ventricular arrhythmias: an institutional experience.

Background: Initial studies have reported excellent safety and efficacy for stereotactic body radiation therapy (SBRT) in patients with refractory ventricular tachycardia (VT).

Methods: This is a single-center retrospective analysis of eight consecutive patients who underwent SBRT for refractory, scar-related VT. The anatomic target for radioablation was defined based on surface 12-lead ECG VT morphology, cardiac magnetic resonance imaging, and electroanatomic mapping data when available.

Recurrent ventricular tachycardia after cardiac sympathetic denervation: Prolonged cycle length with improved hemodynamic tolerance and ablation outcomes.

Introduction: Cardiac sympathetic denervation (CSD) is utilized for the management of ventricular tachycardia (VT) in structural heart disease when refractory to radiofrequency ablation (RFA) or when patient/VT characteristics are not conducive to RFA.

Methods: We studied consecutive patients who underwent CSD at our institution from 2009 to 2018 with VT requiring repeat RFA post-CSD. Patient demographics, VT/procedural characteristics, and outcomes were assessed.

Repeated misclassifications of tachycardia by an implantable cardiac defibrillator.

This case describes repeated misclassifications of SVT due to AV node reentry as VT by an ICD. This case illustrates the limitations of SVT-VT discrimination algorithm. Careful analysis of the stored tracings is of critical importance to reach the correct diagnosis.

Renal denervation as adjunctive therapy to cardiac sympathetic denervation for ablation refractory ventricular tachycardia.

Background: Autonomic modulation is finding an increasing role in the treatment of ventricular arrhythmias. Renal denervation (RDN) has been described as a treatment modality for refractory ventricular tachycardia (VT) in case series.

Objective: The purpose of this study was to evaluate RDN as an adjunctive therapy to cardiac sympathetic denervation (CSD) for ablation refractory VT.

Relationship between sinus rhythm late activation zones and critical sites for scar-related ventricular tachycardia: systematic analysis of isochronal late activation mapping.

Background: It is not known whether the most delayed late potentials are functionally most specific for scar-related ventricular tachycardia (VT) circuits.

Methods And Results: Isochronal late activation maps were constructed to display ventricular activation during sinus rhythm over 8 isochrones. Analysis was performed at successful VT termination sites and prospectively tested.

Tissue voltage discordance during tachycardia versus sinus rhythm: implications for catheter ablation.

Background: Electroanatomic mapping systems are an important tool to identify cardiac chamber voltage and assess channels of slow conduction.

Objective: To assess the correlation between electroanatomic mapping voltage maps obtained during macroreentrant tachycardia compared to sinus rhythm (SR) with a contact mapping system.

Methods: We retrospectively evaluated patients with atrial flutter (AFL) referred for radiofrequency ablation with electroanatomic voltage maps obtained during AFL and SR.

Epicardial ablation of ventricular tachycardia: an institutional experience of safety and efficacy.

Background: Epicardial ablation has been shown to be a useful adjunct for treatment of ventricular tachycardia (VT).

Objective: To report the trends, safety, and efficacy of epicardial mapping and ablation at a single center over an 8-year period.

Methods: Patients referred for VT ablation (June 2004 to July 2011) were divided into 3 groups: ischemic cardiomyopathy (ICM), nonischemic cardiomyopathy (NICM), and idiopathic ventricular arrhythmias (VA).

Noh voice quality.

In Noh, a traditional performing art of Japan, extremely expressive voice quality is used to convey an emotional message. A periodicity of voice appears responsible for these special effects. Acoustic signals were recorded for selected portions of dramatic singing in order to study the acoustic effects of delicate voice control by a master of the Konparu school.

Device extraction in adults with congenital heart disease.

Background: Device extraction is a critical component in the treatment of patients with device-related infections. Due to complex anatomic considerations, device extraction in adults with congenital heart disease presents unique challenges to the electrophysiologist.

Methods: Here, we present a series of device-extraction cases performed in patients with transposition of the great arteries status post either Mustard or Senning surgical procedures that subsequently had permanent pacemakers placed and ultimately developed device-related infections.

Left ventricular apical wall motion abnormality is associated with lack of response to cardiac resynchronization therapy in patients with ischemic cardiomyopathy.

Background: Many patients with appropriate indications fail to respond to cardiac resynchronization therapy (CRT).

Objective: The purpose of our study was to determine the relationship between CRT response and preimplantation apical wall motion abnormality.

Methods: We analyzed data from 83 patients with ischemic cardiomyopathy who underwent CRT.

Asymmetric Ring-Closing Metathesis Catalyzed by Chiral Molybdenum Alkylidene Complexes.

Kinetic resolution was observed in ring-closing metathesis of racemic dienes catalyzed by the newly developed chiral molybdenum alkylidene complexes (R,R)-Mo(CHCMe(2)Ph)(NAr)(TBEC) 1 (Ar = 2,6-i-Pr(2)C(6)H(3), TBEC = 2',2',2",2"-tetrakis(trifluoromethyl)-1,2-bis(2'-hydroxyethyl)cyclopentane) and (R,R)-Mo(CHCMe(2)Ph)(NAr)(TBEH) 2 (Ar = 2,6-i-Pr(2)C(6)H(3), TBEH = 2',2',2",2"-tetrakis(trifluoromethyl)-1,2-bis(2'-hydroxyethyl)cyclohexane). In the case of a prochiral symmetric triene substrate, optically active cyclized product was formed by catalytic ring-closing metathesis with 1, which opens the possibility of a new version of two-directional synthesis. Although the observed enantiomeric excesses were modest to low, this data demonstrates the feasibility of asymmetric induction by chiral alkylidene catalysts in ring-closing metathesis.