Publications by authors named "Osamah Badwan"
Article Synopsis
- Recurrent pericarditis is challenging for both patients and healthcare providers due to its significant impact on health and substantial treatment costs.
- New research since the 2015 European Society of Cardiology Guidelines has improved our understanding of the causes, imaging techniques, and treatment options available for this condition.
- The review emphasizes the importance of imaging-guided therapy and interleukin-1 inhibitors, which have changed how recurrent pericarditis is managed, although more studies are needed to refine diagnosis and treatment timing.
Background: There are significant sex and age differences in left ventricular (LV) remodeling that may lead to disparity in outcomes when used to inform the timing of aortic regurgitation (AR) intervention.
Objectives: The aim of this study was to examine whether left atrial (LA) parameters might represent better criteria than LV parameters to inform the timing of AR intervention.
Methods: Using data on patients with moderate to severe or severe AR with serial echocardiography (2010-2016), the longitudinal trends in left atrial volume index (LAVI) and left atrial reservoir strain (LAr) were evaluated by sex and age.
Article Synopsis
- * In a study involving 1,421 patients monitored for about 6 years, those receiving AVR showed significantly lower risks for both all-cause and cardiovascular mortality compared to those who were managed with clinical surveillance.
- * The benefits of AVR were particularly evident in patients with preserved left ventricular ejection fraction (LVEF ≥50%), as they also showed improvements in heart function over time.
In patients with cardiac amyloidosis, pericardial involvement is common, with up to half of patients presenting with pericardial effusions. The pathophysiological mechanisms of pericardial pathology in cardiac amyloidosis include chronic elevations in right-sided filling pressures, myocardial and pericardial inflammation due to cytotoxic effects of amyloid deposits, and renal involvement with subsequent uremia and hypoalbuminemia. The pericardial effusions are typically small; however, several cases of life-threatening cardiac tamponade with hemorrhagic effusions have been described as a presenting clinical scenario.
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- The study investigates how untreated chronic obstructive coronary artery disease (CAD) affects outcomes in patients undergoing transcatheter aortic valve replacement (TAVR).
- Researchers analyzed a cohort of 1,911 TAVR patients from 2015 to 2021, categorizing them by CAD severity and assessing complications and long-term outcomes.
- Results show that TAVR can be performed safely even in patients with untreated chronic obstructive CAD, with low procedural mortality and complication rates, and no significant increase in long-term mortality or major cardiovascular events based on CAD severity.
COronaVIrus Disease-2019 (COVID-19) is associated with a hypercoagulable state. Intracardiac thrombosis is a potentially serious complication but has seldom been evaluated in COVID-19 patients. We assessed the incidence, associated factors, and outcomes of COVID-19 patients with intracardiac thrombosis.
View Article and Find Full Text PDFImportance: Preclinical studies suggest a potential role for aspirin in slowing abdominal aortic aneurysm (AAA) progression and preventing rupture. Evidence on the clinical benefit of aspirin in AAA from human studies is lacking.
Objective: To investigate the association of aspirin use with aneurysm progression and long-term clinical outcomes in patients with AAA.
Parasitic constrictive pericarditis is a rare entity. We present a case of a 75-year-old man who presented with dyspnea, ascites, and pedal edema and was found to have constrictive pericarditis on multimodality imaging with positive serology for . Treatment required ivermectin and radical pericardiectomy with significant clinical improvement.
View Article and Find Full Text PDFObjective: Coronary artery bypass grafting (CABG) is an established revascularisation strategy for multivessel and left main coronary artery disease. Although aspirin is routinely recommended for patients with CABG, the optimal antiplatelet regimen after CABG remains unclear. We evaluated the efficacies and risks of different antiplatelet regimens (dual (DAPT) versus single (SAPT), and dual with clopidogrel (DAPT-C) versus dual with ticagrelor or prasugrel (DAPT-T/P)) after CABG.
View Article and Find Full Text PDFMany patients with chronic kidney disease have chronically elevated cardiac troponin levels, and if they present with symptoms suggesting an acute coronary syndrome, it is often difficult to determine if this is the correct diagnosis. This article briefly reviews the major challenges in diagnosing acute coronary syndrome in patients with chronic kidney disease, describes the mechanisms and prognostic significance of troponin elevation in chronic kidney disease, and provides a diagnostic algorithm to risk-stratify patients with chronic kidney disease who have troponin elevation and suspected acute coronary syndrome.
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- A study analyzed sex differences in the progression and outcomes of early-stage aortic stenosis (AS) using data from the Cleveland Clinic over a 10-year period involving 2,549 patients, of which 42.5% were women.
- Results showed that women had a slower progression of AS compared to men, with lower rates of aortic valve replacement (AVR) while both sexes had similar overall mortality.
- Women displayed better heart performance indicators over time, such as preserved left ventricular ejection fraction and greater left ventricular hypertrophy, indicating different disease impacts based on sex.
Purpose Of Review: The dicrotic notch (DN) has long been considered a marker of arterial stiffness and compliance. Herein, we explored the recent developments in vascular medicine research in an attempt to assess the DN utility in clinical cardiovascular medicine.
Recent Findings: Since its discovery, several studies have attempted to measure the changes in different parameters of the DN in physiological and pathological states.
Background: Patients with severe tricuspid regurgitation (TR) exhibit high morbidity and mortality. Tricuspid transcatheter edge-to-edge repair (T-TEER) is a rapidly evolving strategy to address the unmet clinical need of severe TR therapies.
Objective: Organize the current body of evidence on outcomes following use of the PASCAL (Edwards Lifesciences) system for T-TEER.
Background: Current guidelines for aortic regurgitation (AR) recommend the same linear left ventricular (LV) dimension for intervention regardless of age and sex.
Objectives: The purpose of this study was to evaluate the impact of age and sex on the degree of LV remodeling and outcomes.
Methods: We included consecutive patients with severe AR who were serially monitored by echocardiogram between 2010 and 2016.
As the mainstay of therapy for end-stage liver disease (ESLD), orthotopic liver transplantation (OLT) has complex effects on multiple organ systems. We present a representative case of acute heart failure with apical ballooning syndrome following OLT and review its mechanisms. Recognition of this and other potential cardiovascular and hemodynamic complications of OLT are essential to periprocedural anesthesia management.
View Article and Find Full Text PDFThe Ross procedure allows replacement of a diseased aortic valve with pulmonary root autograft, possibly avoiding the highly thrombotic mechanical valves and immunologic deterioration of tissue valves in antiphospholipid syndrome (APS). Here, we present the use of the Ross procedure in a 42-year-old woman with mild intellectual disability, APS, and a complex anticoagulation history after she presented with thrombosis of her mechanical On-X aortic valve previously implanted for non-bacterial thrombotic endocarditis.
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