Publications by authors named "Osama Shalaby"
Article Synopsis
- - Spinal muscular atrophy is a genetic condition that leads to muscle weakness and atrophy, and nusinersen is a therapy approved for its treatment in both children and adults.
- - A clinical case series involving 20 pediatric and 18 adult patients in Kuwait was conducted to evaluate the effectiveness and safety of nusinersen, using various motor function assessments.
- - Results showed that about 70% of pediatric and 72% of adult patients experienced significant improvements in motor function, with the therapy being well-tolerated over a period extending beyond four years.
Purpose: The purpose of the study was to evaluate the quality of life (QOL) improvement in evaporative dry eye patients after treatment with intense pulsed light (IPL) therapy compared to punctal plug insertion.
Methods: A prospective comparative interventional study included 30 patients with moderate-to-severe evaporative dry eye. Patients' QOL affection before and after treatment was assessed by the Ocular Surface Disease Index (OSDI) questionnaire.
Background: Ablative carbon dioxide (CO ) laser is still a cornerstone in the management of xanthelasma. However, post-laser complications such as post-inflammatory hyperpigmentation or scarring have to be considered. Heparin sodium was recently suggested as an effective therapeutic modality for xanthelasma.
View Article and Find Full Text PDFExtraocular muscle (EOM) enlargement may be due to a variety of causes. These causes can be classified in three ways: according to pathogenesis and histopathological features, according to the site, and according to the clinical features. Diagnosis of the cause is dependent upon history, clinical examination, and investigations.
View Article and Find Full Text PDFPurpose: To study the role of muscle biopsy in patients with enlarged extraocular muscles.
Methods: A retrospective review of 31 patients who underwent biopsy for extraocular muscle enlargement. Characteristics, including signs, symptoms, imaging findings, and histopathological assessment were examined.
Purpose: evaluation of the role of combined injection of triamcinolone acetonide with 5 Fluorouracil in treatment of the enlarged extraocular muscles secondary to chronic non-specific non-infectious inflammation.
Methods: injection of 0.1 ml of triamcinolone acetonide 40 mg/ml and 0.
Background: Biotin-thiamine-responsive basal ganglia disease (BTRBGD) is a rare treatable autosomal recessive neurometabolic disorder characterized by progressive encephalopathy that eventually leads to severe disability and death if not treated with biotin and thiamine. BTRBGD is caused by mutations in the SLC19A3 gene on chromosome 2q36.6, encoding human thiamine transporter 2 (hTHTR2).
View Article and Find Full Text PDFPurpose: To compare the benefits and side effects of pars plana vitrectomy with those of systemic immune modulator therapy for patients with complicated intermediate uveitis.
Methods: This prospective clinical trial enrolled patients with recurrent intermediate uveitis who exhibited minimal improvement of visual acuity, despite injections of periocular steroids. Twenty patients were randomized to the pars plana vitrectomy group or oral steroid and cyclosporine-A group (10 eyes of 10 patients per group).
Article Synopsis
- Dermatochalasis is a condition often linked to aging that causes both functional and cosmetic issues for individuals, with various treatment options like blepharoplasty and laser therapy available.
- The study aimed to assess the effectiveness of plasma exeresis, a non-surgical method, in treating dermatochalasis in the upper eyelid among 40 female patients who underwent three treatment sessions spaced one month apart.
- Results showed significant improvements in eyelid laxity and marginal crease distance, with 90% of patients experiencing noticeable changes, indicating that plasma exeresis could be a safe and effective treatment option for mild to moderate cases of dermatochalasis.
Aim: To evaluate the role of anterior segment-optical coherence tomography (AS-OCT) in the diagnosis of punctal stenosis and to compare punctal parameters before and after medical treatment.
Patients And Methods: The study was conducted on 40 eyes of 24 patients who had acquired inflammatory punctal stenosis and had persistent epiphora (persistent epiphora group - PEG), and 20 eyes of 10 subjects with normal punctal openings as a control group (control group - CG). We measured the outer punctal diameter (OPD), recorded the visibility of the internal punctum and punctal depth (PD) using AS-OCT, before and 1 month after treatment with preservative free methylprednisolone 5% eye drops.
Purpose: The study aims at evaluating eyebrow elevation as a prognostic factor for frontalis sling procedure success in patients suffering from severe congenital ptosis with poor levator function.
Patients And Methods: This is a retrospective study that included 66 eyelids of 57 patients selected from a surgical log database between January 2016 and June 2019. All of them underwent frontalis suspension surgery for treating severe congenital myogenic ptosis with poor levator function.
Purpose: To study the cosmetic outcome of external dacryocystorhinostomy (Ex-DCR) and to detect the factors affecting it.
Patients And Methods: Prospective randomized interventional study included forty patients who were treated by 40 Ex-DCRs. In twenty patients, medial canthal vertical incision was used and in the other twenty cases, subciliary incision was used.
Orbital metastasis from hepatocellular carcinoma: report of 6 cases.
Ophthalmic Plast Reconstr Surg
August 2015
A series of 6 consecutive cases of orbital metastasis from hepatocellular carcinoma (HCC) were reported in the last 5 years. All patients were men. The age of patients ranged between 47 and 70 years.
View Article and Find Full Text PDFAim: To identify the underlying genetic defect in Egyptian patients with macular corneal dystrophy (MCD).
Methods: A clinical and molecular genetic study was performed on 11 patients from six families with MCD. Clinical diagnosis was confirmed by slit-lamp biomicroscopy and histopathological examination of corneal buttons following keratoplasty.
Purpose: To identify the underlying mutations in two unrelated British families with macular corneal dystrophy (MCD) by screening the carbohydrate sulfotransferase (CHST6) gene.
Design: Case reports and results of DNA analysis.
Methods: Two subjects from two British families with MCD were studied.