Theophylline, an old drug with multi-faceted effects: Its potential benefits in immunological liver injury in rats.

Aim: A low dose of theophylline enhances histone deacetylase activity leading to inhibition of proinflammatory transcription, and inhibits lung fibroblast proliferation. The present work investigated the effect of lowdose theophylline on biochemical and histological pictures of liver tissues in rats with immunological hepatic injury induced by concanavalin A (Con A).

Main Methods: Ratswere assigned to control vehicle,model (Con A) and theophylline groups.