Publications by authors named "Osama M Abdel Latif"
Background: Chronic spontaneous urticaria (CSU) is a persistent skin condition with no known cause or trigger. The unpredictability of CSU attacks lowers patients' quality of life. NOD-like receptor pyrin domain containing 3 (NLRP3) gene dysregulation can result in numerous immunological and inflammatory diseases.
View Article and Find Full Text PDFArticle Synopsis
- Chronic spontaneous urticaria (CSU) is a complex condition, and this study explored the connection between serum zonulin levels, a marker for "leaky gut," and CSU among patients.
- The study included 97 CSU patients and 87 healthy controls, revealing that CSU patients had significantly lower zonulin levels than the controls (median of 2.93 ng/ml versus 3.92 ng/ml).
- Although a positive correlation was found between serum zonulin and C-reactive protein, no significant relationship was established between zonulin levels and disease activity or immunoglobulin E levels, suggesting factors like diet and medication could impact zonulin levels in CSU patients.
The nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome is a high molecular weight protein complex that has been linked to a variety of allergic and inflammatory disorders in humans, including atopic dermatitis (AD). Polymorphisms in NLRP3 genes could lead to immune dysregulation. This case-control study aimed to assess the association between NLRP3 inflammasome (rs10754558) gene polymorphism in AD and the incidence and severity of the disease.
View Article and Find Full Text PDFPollen is responsible for seasonal allergies, such as allergic rhino-conjunctivitis (AR), and has become a growing public health concern. Climate change affects the range of allergenic species as well as the timing and length of the pollen season. In Egypt, data on pollinosis are scarce.
View Article and Find Full Text PDFBackground: Behçet's syndrome (BS) is a multi-systemic vasculitis characterized by recurrent oral ulcers, genital ulcers, ocular lesions, and other systemic manifestations. As there is no laboratory diagnostics of BS, the diagnosis is mainly clinical.
Objective: To investigate the utility of the autoantibody against tubulin-α-1c in diagnosis of BS and its clinical significance.