Publications by authors named "Osama M Abdel Latif"

Background: Chronic spontaneous urticaria (CSU) is a persistent skin condition with no known cause or trigger. The unpredictability of CSU attacks lowers patients' quality of life. NOD-like receptor pyrin domain containing 3 (NLRP3) gene dysregulation can result in numerous immunological and inflammatory diseases.

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Article Synopsis
  • Chronic spontaneous urticaria (CSU) is a complex condition, and this study explored the connection between serum zonulin levels, a marker for "leaky gut," and CSU among patients.
  • The study included 97 CSU patients and 87 healthy controls, revealing that CSU patients had significantly lower zonulin levels than the controls (median of 2.93 ng/ml versus 3.92 ng/ml).
  • Although a positive correlation was found between serum zonulin and C-reactive protein, no significant relationship was established between zonulin levels and disease activity or immunoglobulin E levels, suggesting factors like diet and medication could impact zonulin levels in CSU patients.
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The nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome is a high molecular weight protein complex that has been linked to a variety of allergic and inflammatory disorders in humans, including atopic dermatitis (AD). Polymorphisms in NLRP3 genes could lead to immune dysregulation. This case-control study aimed to assess the association between NLRP3 inflammasome (rs10754558) gene polymorphism in AD and the incidence and severity of the disease.

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Pollen is responsible for seasonal allergies, such as allergic rhino-conjunctivitis (AR), and has become a growing public health concern. Climate change affects the range of allergenic species as well as the timing and length of the pollen season. In Egypt, data on pollinosis are scarce.

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Background: Behçet's syndrome (BS) is a multi-systemic vasculitis characterized by recurrent oral ulcers, genital ulcers, ocular lesions, and other systemic manifestations. As there is no laboratory diagnostics of BS, the diagnosis is mainly clinical.

Objective: To investigate the utility of the autoantibody against tubulin-α-1c in diagnosis of BS and its clinical significance.

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