[Role of enteral feeding mixture based on soy in correction of immune status of patients with burn wounds].

The authors have studied the immune status of patients with burn wounds, which had early received to their complex therapy of burn disease an additional enteral feeding based on soy suspension. All populations of immunocompetent cells have been revealed to be activated, especially T-helper lymphocytes taking part in reparative processes, antibody production, synthesis of anti-inflammatory cytokines, thus contributing to regenerative processes taking place in burn wounds, speeding patients' recovering.

[Modification of the phospholipid composition of the cardiomyocyte sarcolemma in izadrin-induced myocarditis].

A modification of phospholipid composition in rat cardiomyocyte sarcolemma occurring during isadrin myocarditis has been investigated. The fractions of sphingomyelin (SphM), phosphatidylserine (PhS), phosphatidylinositol (PhI), phosphatidylcholine (PhCh), phosphatidylethanolamine (PhEA) have been isolated. The shifts in phospholipid composition during isadrin myocarditis expressing in increase of the amount of choline-containing (PhCh + SphM) and decrease of acid (PhS + PhI) phospholipids have been revealed.

[The beta-adrenergic regulation of the Na, K-ATPase activity in the sarcolemma of the heart muscle].

Using a sensitive potentiometric method the effect of isoproterenol upon the activity of Na, K-ATPase in cardiomyocytes has been studied. The activity of the enzyme in rat sarcolemma at isoproterenol-induced myocarditis decreases by 42%. A direct action of isoproterenol on the Na, K-ATPase activity in sarcolemma in vitro has been investigated.

[Fatty acid composition of total lipids and phospholipids of membrane preparations of transport ATPases].

The fatty acid composition of total lipids and phospholipids of duck salt gland Na,K-ATPase (outer plasma membrane) and of rabbit skeletal muscle Ca-ATPase (intracellular membrane) was investigated. The bulk of Na,K-ATPase fatty acids is represented by palmitic (16:0), oleic (18:1), stearic (18:0) and arachidonic (20:4) acids. The duck salt gland is characterized by rather a high content of unsaturated fatty acids, especially of arachidonic acid.

[Effect of chronic hyperphenylalaninemia and hypoxia on the effectiveness of the alpha-ketoglutarate shunt in the brain].

The effects of hypoxia and chronic hyperphenylalaninaemia (HPA) on the intensity of the alpha-oxoglutarate shunt in rat brain after injection of [5-14C]glutamate were investigated. The reaction of reducing carboxylation of alpha-oxoglutarate was shown to be the rate-limiting step for the whole pathway. The deceleration of this reaction under chronic HPA or, conversely, its increase under short-term heavy hypoxia led to a corresponding decrease or increase of fatty acid synthesis in the brain with [5-14C]glutamate as a radioactive precursor.

[Use of different precursors of fatty acid biosynthesis in the brain in chronic hyperphenylalaninemia].

The incorporation of 14C from 2-14C-acetate, 1-6-14C-glucose and 5-14-C-glutamate into fatty acids of brain lipids under chronic hyperphenylalaninemia (HPA) was investigated. A decrease of lipogenesis intensity was demonstrated in young rat brain. In the HPA a decrease in the labelling of fatty acids occurred due to inhibition of the enzymes of fatty acid biosynthesis and to disturbance of metabolic pathways involved in lipogenesis via acentyl-CoA.

[Participation of glutamate and alanine in amino acid biosynthesis, in lipogenesis, and in gluconeogenesis in the brain].

The participation of glutamate and alanine in lipogenesis and gluconeogenesis of brain was investigated. 5(14)C glutamate was injected intracisternally in an amount of 5 mcCu/l g tissue and 3(14)C-alanine was injected subcutaneously 30 mcCu/100 g body weight. Labels from glutamate and alanine were recovered in different lipid franctions -- in phospholipids, glycerides, free fatty acids and cholesterol, as well as in glucose and glycogen.

[Change in the activity of NAD- and NADP-specific malate dehyrdogenases in oxygen deficiency in different tissues].

NAD-dependent malate dehydrogenase (1.1.1.