Publications by authors named "Oryoji D"
Article Synopsis
- Cry j 1 is a significant allergen from Japanese cedar pollen that activates Th2 cells through its peptide sequence, specifically binding to HLA-DP5.
- The study found that specific amino acids, Ser(-2) and Lys(-3), in the N-terminal region of a related peptide (NF-pCj1) are essential for strong binding to HLA-DP5 and effective presentation to T-cells.
- Mutating these amino acids to Glu reduced the peptide's affinity for HLA-DP5 and decreased T-cell activation by about 2-fold, indicating their critical role in enhancing immune responses against this allergen.
The immunogenicity of a T cell Ag is correlated with the ability of its antigenic epitope to bind HLA and be stably presented to T cells. This presents a challenge for the development of effective cancer immunotherapies, as many self-derived tumor-associated epitopes elicit weak T cell responses, in part due to weak binding affinity to HLA. Traditional methods to increase peptide-HLA binding affinity involve modifying the peptide to reflect HLA allele binding preferences.
View Article and Find Full Text PDFBackground: Concomitant use of methotrexate (MTX) improves the clinical efficacy of anti-TNF agents in the treatment of rheumatoid arthritis (RA). We aimed to clarify the cytotoxic effect of MTX on transmembrane TNF (tmTNF)-expressing cells treated with anti-TNF agents.
Methods: Jurkat T cells stably expressing tmTNF were used for the following experiments.
Objectives: We investigated the effect of daily folic acid supplementation on methotrexate (MTX) toxicity and efficacy in Japanese patients with rheumatoid arthritis (RA).
Methods: We followed 19 patients treated with MTX who switched from taking weekly 5 mg folic acid supplementation (weekly regimen) to 1.25 mg daily (daily regimen).
Relapsing polychondritis (RP) is a rare systemic autoimmune disease that affects cartilaginous structures. RP causes tracheobronchomalacia (TBM) by affecting the bronchial cartilage. TBM is a fatal condition characterized by excessive weakening of the walls of the trachea and bronchi.
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- The study aimed to identify genetic differences between Hashimoto thyroiditis (HT) and Graves' disease (GD) by analyzing single nucleotide polymorphisms (SNPs) in Japanese patients.
- A significant SNP at the VAV3 locus was found to be specifically associated with HT, but not with GD, indicating a potential genetic marker for HT susceptibility.
- This discovery sheds light on the molecular mechanisms underlying HT, highlighting the role of VAV3 as a guanine nucleotide exchange factor.
Article Synopsis
- Previous studies hinted at the link between human leukocyte antigen (HLA) and Crohn's disease (CD), but research on HLA class I antigens in Japan was limited.
- In this study with 208 Japanese CD patients and 384 healthy controls, novel positive associations were found between CD and certain HLA class I antigens (HLA-A*02:01 and HLA-A*02:07), along with confirmed associations for HLA-Cw*14:02 and HLA-B*51:01.
- The study also identified negative associations with other HLA antigens (HLA-A*24:02 and HLA-B*07:02) and suggested that HLA class I genes might play dual roles
Article Synopsis
- * Researchers identified different susceptible HLA molecules for GD (4 types) and HT (2 types), as well as specific protective HLA haplotypes that may prevent the development of these diseases.
- * The findings suggest that HLA plays a crucial role in the differing immunological pathways of GD and HT, indicating complex interactions between protective and susceptible HLA alleles.
Otitis media is one of the common organ injuries that appear during the course of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We experienced four patients with myeloperoxidase (MPO)-ANCA-positive AAV with otitis media. All were elderly Japanese women.
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