Publications by authors named "Ory F"

Living with chronic conditions like diabetes mellitus (DM) or insulin resistance (IR) requires significant self-management, adding to daily life stressors. This stress, known as diabetes distress, along with health empowerment from proper diet and lifestyle, and motivation to eat healthily, greatly impacts quality of life and disease outcomes. Different patient subgroups (type 1 diabetic (T1DM), type 2 diabetic (T2DM), and insulin resistant (IR) individuals) face these challenges differently.

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Chikungunya virus (CHIKV) was isolated from humans in an outbreak of a febrile illness during July and August 2015 in the central valleys of Chiapas, Mexico. Sera obtained from 80 patients were tested for CHIKV RNA by reverse transcriptase polymerase chain reaction (RT-PCR) and for IgM and IgG antibodies by an enzyme linked immunoassay and a commercial indirect immunofluorescence test for CHIKV and dengue virus (DENV). Of the 80 patients, 67 were positive, including 50 for RNA and 17 for IgM.

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Diabetes-specific distress (DD) is a crucial predictor of patients' self-care, necessitating reliable screening tools. The Diabetes Distress Scale captures typical sources of patients' distress effectively. The Hungarian Diabetes Distress Scale (HDDS) was employed in two studies with 450 type 2 diabetes patients.

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Background: To address the growing prevalence of youth mental health problems, early intervention is crucial to minimize individual, societal, and economic impacts. Indicative prevention aims to target emerging mental health complaints before the onset of a full-blown disorder. When intervening at this early stage, individuals are more responsive to treatment, resulting in cost-effective outcomes.

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We sequenced the genomes of recently discovered (CCOS 2000) and of the type strains of closely related (DSM 7262) and (LMG 21716). The three genomes set the basis to unambiguous diagnostic of these honey bee associated bacteria.

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Introduction: Over 25% of Dutch young people are psychologically unhealthy. Individual and societal consequences that follow from having mental health complaints at this age are substantial. Young people need care which is often unavailable.

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Introduction: To optimize treatment, it is of utmost importance to take into account the myriad of biological, social, and psychological changes that young people go through during adolescence which make them more vulnerable for developing mental health problems. Biocueing, a non-invasive method to transform physiological parameters into an observable signal, could strengthen stress- and emotion regulation by cueing physiologically unusual values in daily life. The aim of this study is to investigate the usability, feasibility, and exploratory effect of biocueing in addition to ENgage YOung people earlY (ENYOY), a moderated digital social therapy-platform, in young people with emerging mental health complaints.

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Trans-generational immune priming involves the transfer of immunological experience, acquired by the parents after exposure to pathogens, to protect their progeny against infections by these pathogens. Such natural mechanisms could be exploited to prevent disease expression in economically important insects, such as the honey bee. This mechanism occurs when honey bee queens are exposed to the pathogenic bacterium Paenibacillus larvae.

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Article Synopsis
  • MuV has triggered three epidemic waves in Spain since 2005, despite a high vaccination rate.
  • Genetic analysis identified seven significant variants and 88 different haplotypes, with the original variant dominating the first two waves before being replaced by others.
  • To improve mumps surveillance, it is important to complement SH gene sequencing with other variable markers right after a new genotype appears, but tracking new SH variants may not require this approach afterward.
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Introduction: Multiple system atrophy (MSA) is a rare degenerative neurological disorder in adults. It induces parkinsonian and/or cerebellar syndrome associated with dysautonomia. Pharyngolaryngeal symptoms are common.

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  • Nursing home residents in France accounted for half of COVID-19 deaths in the 2020 spring wave, prompting a study to identify factors linked to outbreaks in nursing homes (NHs).
  • A July 2020 questionnaire study involving 231 NHs revealed that factors like in-room meal service and early family visit bans were associated with a lower risk of COVID-19 cases, despite strict measures like resident confinement.
  • The study concluded that while strict lockdowns might help prevent outbreaks, they raise ethical concerns regarding residents' wellbeing, suggesting that communal dining cessation is the most effective preventive measure.
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  • * A total of 162 samples were analyzed, with findings showing high sensitivity (up to 100%) and varying specificity (as low as 52.4%) for both rubella and measles tests.
  • * The chemiluminescence and electrochemiluminescence methods proved to have the best performance for detecting IgM antibodies for both viruses.
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Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules. The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based screening, we discovered that KCNQ5, KCNN4, and KCNK5 potassium channels positively modulate cationic CPP direct translocation into cells by decreasing the transmembrane potential (V).

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The MMR vaccination program was introduced in Spain in 1981. Consistently high vaccination coverage has led to Spain being declared free of endemic measles transmission since 2014. A few imported and import-related cases were reported during the post-elimination phase (2014 to 2020), with very low incidence: three cases per million of inhabitants a year, 70% in adults.

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The genera Phlebovirus transmitted by Diptera belonging to the Psychodidae family are a cause of self-limited febrile syndrome in the Mediterranean basin in summer and autumn. Toscana virus can also cause meningitis and meningoencephalitis. In Spain, Toscana, Granada, Naples, Sicily, Arbia and Arrabida-like viruses have been detected.

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Between the ages of 12 and 25 the onset of mental disorders typically occurs, and the burden of mental health problems is greatest for this group. Indicated preventive interventions to target individuals with subclinical symptoms to prevent the transition to clinical levels of disorders have gained considerable traction. However, the threshold to seek help appears to be high even when help is needed.

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In August 2018, a fatal autochthonous case of Crimean-Congo hemorrhagic fever was confirmed in western Spain. The complete sequence of the viral genome revealed circulation of a new virus because the genotype differs from that of the virus responsible for another case in 2016. Practitioners should be alert to possible new cases.

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Background: The emergence of Zika virus (ZIKV) represents a threat with consequences on maternal and children's health. We aimed to assess the clinical and epidemiological characteristics of pregnant women returning from ZIKV affected areas, and the effects of maternal ZIKV infection on birth outcomes and children's health.

Methods: This was a hospital-based prospective observational study conducted at the Hospital Clínic of Barcelona and Hospital Sant Joan de Déu, Barcelona, Spain, from January 2016 to February 2020.

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Previous studies have demonstrated that the angle of women's lumbar curvature affects men's attractiveness judgments of them. The theoretically optimal angle of lumbar curvature provides better resistance against both hyperlordosis and hypolordosis as biomechanical costs of a bipedal fetal load that could impair a woman's fertility. Since men find this attribute attractive, women aim to emphasize it by wearing high-heeled shoes.

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BCR-ABL is an aberrant tyrosine kinase responsible for chronic myeloid leukemia (CML). Tyrosine kinase inhibitors (TKIs) induce a potent antileukemic response mostly based on the inhibition of BCR-ABL, but they also increase the activity of Natural Killer (NK) and CD8+ T cells. After several years, patients may interrupt treatment due to sustained, deep molecular response.

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Article Synopsis
  • Tyrosine kinase inhibitors (TKIs), like dasatinib, are effective in treating chronic myeloid leukemia (CML) and have shown an unexpected resistance to HIV-1 infection in CD4+ T cells from CML patients on treatment.
  • In patients who safely stopped TKI treatment after achieving a deep molecular response, their CD4+ T cells experienced phosphorylation of SAMHD1, making them more susceptible to HIV-1 infection over a year later.
  • Despite this increased susceptibility, CD4+ T cells from these patients showed a significantly lower frequency of HIV-1 proviral integration compared to healthy donors, potentially due to enhanced NK cell activity and increased cytotoxic responses in both CD4+ and CD8+
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