Publications by authors named "Orville O Kirkland"
Article Synopsis
- Neutralizing antibody (NAb) titer is crucial for measuring protection against SARS-CoV-2 infection, but current testing methods are not widely accessible.
- A new lateral flow assay has been developed that measures the amount of neutralized SARS-CoV-2 receptor-binding domain (RBD) that no longer binds to ACE2, showing a strong correlation with NAb titer from vaccinated and recovered patients.
- This testing method outperforms existing techniques and could potentially be used for large-scale assessments of immunity in the population, making it easier for individuals to check their NAb titer at home.
Sendai virus (SeV, formally murine respirovirus) is a membrane-enveloped, negative-sense RNA virus in the Paramyxoviridae family and is closely related to human parainfluenza viruses. SeV has long been utilized as a model paramyxovirus and has recently gained attention as a viral vector candidate for both laboratory and clinical applications. To infect host cells, SeV must first bind to sialic acid glycolipid or glycoprotein receptors on the host cell surface via its hemagglutinin-neuraminidase (HN) protein.
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