Structural pathways related to the subventricular zone are decreased in volume with altered microstructure in young adult males with autism spectrum disorder.

Autism spectrum disorder is a neurodevelopmental condition characterized by reduced social communication and repetitive behaviors. Altered neurogenesis, including disturbed neuronal migration, has been implicated in autism spectrum disorder. Using diffusion MRI, we previously identified neuronal migration pathways in the human fetal brain and hypothesized that similar pathways persist into adulthood, with differences in volume and microstructural characteristics between individuals with autism spectrum disorder and controls.

Abnormal visual cortex activity using functional magnetic resonance imaging in treatment resistant photophobia in Friedreich Ataxia.

Purpose: Friedreich ataxia (FDRA) is a debilitating neurodegenerative disease that can have ophthalmological manifestations including visual dysfunction, nystagmus, and optic atrophy. However, severe photophobia has not been reported nor evaluated with functional magnetic resonance imaging (fMRI).

Methods: A 64-year-old white female with a 37-year history of FDRA presented to the eye clinic with worsening photophobia of 3 years.

Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway.

Hedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in the cerebrum, cerebellum, and cerebral ventricles, suggesting the association between brain morphology and the constitutive hyperactivation of hedgehog signaling, while the changes of regional brain volumes in upregulated hedgehog signaling pathway remains unclear so far. Herein, we investigated comprehensive brain regional volumes using quantitative structural brain MRI, and identified increased volumes of amygdala, striatum, and pallidum on the global segmentation, and increased volumes of the lateral and medial parts of the central nucleus of the amygdala on the detail segmentation in heterozygous deletion mice.

Imaging of developing human brains with ex vivo PSOCT and dMRI.

The human brain undergoes substantial developmental changes in the first five years of life. Particularly in the white matter, myelination of axons occurs near birth and continues at a rapid pace during the first 2 to 3 years. Diffusion MRI (dMRI) has revolutionized our understanding of developmental trajectories in white matter.

Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography.

Lissencephaly (LIS) is a rare neurodevelopmental disorder with severe symptoms caused by abnormal neuronal migration during cortical development. It is caused by both genetic and non-genetic factors. Despite frequent studies about the cortex, comprehensive elucidation of structural abnormalities and their effects on the white matter is limited.

Integration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study.

Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, communication and repetitive, restrictive behaviors, features supported by cortical activity. Given the importance of the subventricular zone (SVZ) of the lateral ventrical to cortical development, we compared molecular, cellular, and structural differences in the SVZ and linked cortical regions in specimens of ASD cases and sex and age-matched unaffected brain.

Methods: We used magnetic resonance imaging (MRI) and diffusion tractography on postmortem brain samples, which we further analyzed by Whole Genome Bisulfite Sequencing (WGBS), Flow Cytometry, and RT qPCR.

Nonmetric Variants of Anatolian Crania: A Preliminary Study.

Analysis of nonmetric cranial variants has been essential for identifying the human population through osteologic analysis and genetic affinities. This study aimed to examine the nonmetric cranial variants to evaluate differences among sex and side correlations in Anatolian dry skulls. This study was carried out on 50 Anatolian adult dry human skulls (22 males, 28 females) with suitable features (nonfractured and/or with necessary features) out of a total of 97 dry skulls.

Comprehensive Volumetric Analysis of -Null Mouse Model for Rett Syndrome by T2-Weighted 3D Magnetic Resonance Imaging.

Rett syndrome (RTT) is a severe progressive neurodevelopmental disorder characterized by various neurological symptoms. Almost all RTT cases are caused by mutations in the X-linked methyl-CpG-binding protein 2 () gene, and several mouse models have been established to understand the disease. However, the neuroanatomical abnormalities in each brain region of RTT mouse models have not been fully understood.

Preoperative and postoperative high angular resolution diffusion imaging tractography of cerebellar pathways in posterior fossa tumors.

This study aimed to utilize high angular resolution diffusion magnetic resonance imaging (HARDI) tractography in the mapping of the pathways of the cerebellum associated with posterior fossa tumors (infratentorial neoplasms) and to determine whether it is useful for preoperative and postoperative evaluation. Retrospective data from 30 patients (age 2-16 yr) with posterior fossa tumor (17 low grade, 13 high grade) and 30 age-sex-matched healthy controls were used. Structural and diffusion-weighted images were collected at a 3-tesla scanner.

Anatomy education in Ottoman-Turkish veterinary schools during 19 century and Papier-Mache models.

Veterinary medicine was recognized as a scientific discipline for the first time in 1762 in France. After a while, the first Ottoman-Turkish veterinary school was established in 1842, primarily for the improvement and welfare of army horses. There is not much detailed information about the content of the anatomy education and materials in the early days of veterinary schools apart from the anecdote that Gurlt's illustrated anatomy books were being used.

Small Nucleus Accumbens and Large Cerebral Ventricles in Infants and Toddlers Prior to Receiving Diagnoses of Autism Spectrum Disorder.

Early interventions for autism spectrum disorder (ASD) are increasingly available, while only 42-50% of ASD children are diagnosed before 3 years old (YO). To identify neuroimaging biomarkers for early ASD diagnosis, we evaluated surface- and voxel-based brain morphometry in participants under 3YO who were later diagnosed with ASD. Magnetic resonance imaging data were retrospectively obtained from patients later diagnosed with ASD at Boston Children's Hospital.

Symptom-Related Differential Neuroimaging Biomarkers in Children with Corpus Callosum Abnormalities.

We aimed to identify symptom-related neuroimaging biomarkers for patients with dysgenesis of the corpus callosum (dCC) by summarizing neurological symptoms reported in clinical evaluations and correlating them with retrospectively collected structural/diffusion brain magnetic resonance imaging (MRI) measures from 39 patients/controls (mean age 8.08 ± 3.98).

A Dissectional Study of the Level of Anterior Commissure of the Larynx.

Purpose: Precise knowledge of the level of the vocal fold as projected on the external thyroid cartilage is of critical importance for the performance of many surgical approaches. This study aims to identify the level of the anterior commissure, as well as the lengths of the vocal muscle and arytenoid cartilage in Turkish population.

Materials And Method: Specimens were collected after autopsy from the Council of Forensic Medicine.

Variations of the digastric muscle and accessory bellies - A study of gross anatomic dissections.

Objective: Variations of the bellies of the digastric muscle is reported for a long time and is not uncommon. However, there is still not a full consensus about the classifications and many different types of variations. The aim of this study was to examine the variations of the digastric muscle on cadaver dissections and to create a pictorial collection of variations related to present-day by combining with existing knowledge.

Tracing the papier mache anatomical models of Ottoman Turkish medicine and Louis Thomas Jerôme Auzoux.

Papier-mâché means chewed paper, and it defines a method. Various decorative products and functional tools have been produced with this method, which includes various techniques and materials. Maybe, the most interesting one among these is anatomic models developed and spread around the world by the French physician Louis Thomas Jerôme Auzoux (1797-1880) at the beginning of the nineteenth century.

Evaluation of normal tibial tubercle to trochlear groove distance in adult Turkish population.

Purpose: Many studies have confirmed the significance of tibial tuberosity-trochlear groove (TTTG) distance measurement for the preoperative assessment of tibial tubercle osteotomy and refixation of the patients that need surgery. TTTG distance is being used as threshold value for surgery decision. The purpose is to determine the TTTG values for the adult Turkish population and compare this with the values of other studies and establish a possible index.

Greater palatine foramen: assessment with palatal index, shape, number and gender.

Background: Accurate knowledge of location and relation with different para- meters of the greater palatine foramen (GPF) is a crucial necessity in performing a variety of anaesthesiological, dental and surgical procedures. The main aim of this study was to identify the GPF's locations, numbers and shapes via associating with gender and palatal indices and compare with literature results.

Materials And Methods: This study was held on the cranium collections of the many anatomy departments in Turkey.

Characteristics of lingual papillae in diabetic rats.

Diabetes mellitus (DM) is a metabolic disorder resulting with many different complications including soft tissue abnormalities in the oral cavity such as periodontitis and salivary and taste dysfunction. Previous studies also reported fungal and bacterial infections in oral cavity in these patients. This study aims to represent three dimentional morphologic ultrastructural changes of the diabetic rat tongue via scanning electron microscopy.

Does cigarette smoke exposure lead to histopathological alterations in the olfactory epithelium? An electron microscopic study on a rat model.

Objective: This study was conducted to examine the influence of smoke exposure of variable duration on the ultrastructure of and histopathologic and morphologic alterations in the olfactory epithelium.

Methods: A total of 24 Wistar albino rats were randomly assigned to three groups and fed a standard rat chow and tap water. Experimental rats in groups I and II were exposed to cigarette smoke in a glass cabin over a period of 2 months for 5 or 15 min, respectively, four times daily; control rats (group III) were not exposed to cigarette smoke.

Miratü'lEbdan Fi Teşrih-i Azaül-İnsan: first printed illustrated anatomy book in Ottoman-Turkish medicine.

Background: Medical education in Ottoman-Turkish medicine was shaped by the influence of Claudius Galenus (c.130-c.210) and Ibn-i Sina (c.