Publications by authors named "Orton C"

Background: Adults living with head and neck burn injuries experience psychosocial consequences due to scarring as well as functional disabilities. However, the impact of head and neck burns on long-term self-reported psychosocial outcomes, return to work, and need for reconstructive surgery has not been well described. This study investigates the unique longitudinal problems in psychosocial and functional recovery faced by adults with head and neck burn injuries.

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  • Federated networks enhance data privacy by allowing analysis without transferring sensitive data, supporting trustworthy data analysis in healthcare research.
  • The International COVID-19 Data Alliance (ICODA) tested a federated network with partners to analyze data from the International Perinatal Outcome in the Pandemic (iPOP) Study, facing both challenges and benefits in the process.
  • Establishing these networks requires significant investment and planning for technology and governance, which can lead to powerful collaborative research opportunities using health data from various countries.
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Background: A national database is used to evaluate pediatric burn survivor outcomes, but the generalizability to the United States pediatric burn injury population is unclear, as only 60% of enrollees are U.S. residents.

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Return to work (RTW) after burn injury is dependent on many variables, including type and location of burn injury, access to care, and pre-injury mental and physical health. Noting that prior studies were limited by small sample sizes, we aimed to use a large database to explore the associations between hand burn severity, functional hand outcomes, and RTW post-injury. Data from a multicenter longitudinal study were analyzed.

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Older adults are at a higher risk of complications after burn injuries since many physical and mental changes are compounded by increasing age. Few studies have targeted the long-term effects of burns on older adults. Therefore, this study will investigate the long-term physical and mental health outcomes in older adults.

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  • Voice is critical for communication, but acute burn care procedures like intubation and tracheostomy can negatively affect voice quality.
  • A study from 2015-2023 involving 582 burn survivors found that 65 reported voice changes, with prevalence noted at discharge and lasting up to 60 months.
  • Factors such as type of burn and duration of mechanical ventilation significantly correlated with the likelihood of experiencing these long-term voice changes.
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Background: Prior open reduction and internal fixation (ORIF) of tibial plateau fracture (TPF) adds complexity to subsequent total knee arthroplasty (TKA). The purpose of this study was to compare the outcomes of patients undergoing a TKA following prior ORIF of TPF to patients undergoing a primary TKA for osteoarthritis and an aseptic revision TKA.

Methods: There were 52 patients who underwent primary TKA following prior ORIF of TPF between January 2009 and June 2021, who were included and matched in a 1:4 ratio to 208 patients undergoing primary TKA.

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Daily rehabilitation after burn injury is vital for the prevention of function-limiting contractures. However, adherence to prescribed therapy following acute burn hospitalization has historically been low and not well-studied. Studies involving virtual reality technology have demonstrated an association with improved functional outcomes in burn therapy.

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Respiratory particles produced during vocalized and nonvocalized activities such as breathing, speaking, and singing serve as a major route for respiratory pathogen transmission. This work reports concomitant measurements of exhaled carbon dioxide volume (VCO) and minute ventilation (VE), along with exhaled respiratory particles during breathing, exercising, speaking, and singing. Exhaled CO and VE measured across healthy adult participants follow a similar trend to particle number concentration during the nonvocalized exercise activities (breathing at rest, vigorous exercise, and very vigorous exercise).

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Spontaneous intracerebral hemorrhage (sICH) is associated with significant morbidity and mortality, with subsequent hematoma expansion (HE) linked to worse neurologic outcomes. Accurate, real-time predictions of the risk of HE could enable tailoring management-including blood pressure control or surgery-based on individual patient risk. Although multiple radiographic markers of HE have been proposed based on standard imaging, their clinical utility remains limited by a reliance on subjective interpretation of often ambiguous findings and a poor overall predictive power.

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Background: Ambulatory electrocardiogram (AECG) monitoring is an attractive method for objectively identifying atrial fibrillation (AF) symptoms by documenting simultaneous arrhythmia with symptomatic episodes. However, no study yet has evaluated this simultaneous symptom-rhythm correlation in patients with heart failure (HF). We aimed to measure the correlation between symptoms and atrial arrhythmia (ATAF) episodes among patients with HF and known AF using prolonged AECG monitoring.

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  • Management of atrial fibrillation (AF) often focuses on alleviating symptoms, but the relationship between these symptoms and heart rhythm disturbances (like atrial tachycardia/AF) is not well understood when monitored using ambulatory electrocardiography (AECG).
  • A study analyzed AECG data from 742 patients, revealing a low symptom-rhythm correlation (SRC) of 0.39, indicating that while AT/AF events significantly increase the likelihood of symptoms, many episodes do not correspond well with reported symptoms.
  • Factors such as previous treatment for AF and lower heart rates were found to negatively impact SRC, highlighting the need for more in-depth research to better link symptoms and heart rhythms for improved patient care.
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Background: Singing for lung health (SLH) is an arts-based breathing control and movement intervention for people with long-term respiratory conditions, intended to improve symptoms and quality of life. Online, remotely delivered programmes might improve accessibility; however, no previous studies have assessed the effectiveness of this approach.

Methods: We conducted an assessor-blind randomised controlled trial comparing the impact of 12 weeks of once-weekly online SLH sessions against usual care on health-related quality of life, assessed using the RAND 36-Item Short Form Health Survey (SF-36) Mental Health Composite (MHC) and Physical Health Composite (PHC) scores.

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Excessive dynamic airway collapse (EDAC) is a recognized cause of exertional dyspnea arising due to invagination of the trachea and/or main bronchi. EDAC is typically assessed by evaluating large airway movement with forced expiratory maneuvers. This differs from the respiratory response to exercise hyperpnea.

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  • * A harmonized curation approach was developed to create comparable patient groups across different datasets from England, Wales, and Scotland, addressing inconsistencies in data coding.
  • * Tools and resources, including codelists and metadata, have been provided to assist researchers in recreating these patient cohorts in various EHR systems, facilitating future respiratory research.
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  • Trusted Research Environments (TREs) aim to facilitate secure data access while adhering to the "five-safes" framework for privacy, though there is inconsistency in how these frameworks are applied across different TREs in the UK.
  • The study focuses on documenting governance features of major UK-TREs to enhance collaborative analyses and future multi-TRE collaborations.
  • Key findings show that all 15 TREs analyzed require human-operated disclosure checks for data pooling, have distinct access request procedures, and varying levels of disclosure control guidance, with only 40% achieving ISO 20071 accreditation as of 2023.
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Background And Objective: Bronchoscopic transbronchial lung cryobiopsy (TBLC) is a guideline-endorsed alternative to surgical lung biopsy for tissue diagnosis in unclassifiable interstitial lung disease (ILD). The reported incidence of post-procedural bleeding has varied widely. We aimed to characterize the incidence, severity and risk factors for clinically significant bleeding following TBLC using an expert-consensus airway bleeding scale, in addition to other complications and diagnostic yield.

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Purpose Of Review: Chronic bronchitis is a phenotype of chronic obstructive pulmonary disease (COPD), characterized by chronic cough and sputum production, associated with an increased rate of COPD exacerbations and hospital admissions, a more rapid decline in lung function and reduced life expectancy. Despite optimal medical therapy, chronic bronchitis remains difficult to treat. Interventional bronchoscopic procedures offer novel therapeutic approaches to this highly symptomatic condition.

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Introduction: Phonation and speech are known sources of respirable aerosol in humans. Voice assessment and treatment manipulate all the subsystems of voice production, and previous work (Saccente-Kennedy et al., 2022) has demonstrated such activities can generate >10 times more aerosol than conversational speech and 30 times more aerosol than breathing.

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The care required to recover serious burn injuries is costly. In the United States, these costs are often borne by patients. Examining the relationship between out-of-pocket (OOP) costs and health-related quality of life (HRQL) is important to support burn survivors.

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  • Preterm birth (PTB) is a major cause of infant mortality globally, and studies show mixed results regarding its rates during COVID-19 lockdowns, with changes ranging from -90% to +30%.
  • Analysis of data from 52 million births in 26 countries indicates modest reductions in PTB rates during the first three months of lockdown, but no significant changes in the fourth month.
  • High-income countries showed an increase in stillbirth risk during the first month of lockdown, with Brazil experiencing increased stillbirth rates throughout the entire lockdown period, highlighting the need for further investigation into these trends.
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  • Research-ready data enhances the rigor and opportunities in scientific research by creating a unified data environment, particularly valuable for analyses involving multiple cohorts.
  • The C-Surv model was developed through stakeholder feedback and is designed with a structured approach based on 18 relevant data themes, using standard naming conventions for variables in longitudinal studies.
  • Implementing this common data model provides significant advantages, as shown by reduced data preparation times compared to specific cohort models, and aids in the efficient discovery and analysis of research data.
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The aim of this study was to determine the appetite-related responses to breaking up prolonged sitting with physical activity bouts differing in frequency and duration among adult females. Fourteen sedentary females aged 34 ± 13 years with a body mass index of 27.1 ± 6.

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