Anti-MDA5 positive clinically amyopathic dermatomyositis presenting with severe cardiomyopathy.

Background: Anti-MDA5 (Melanoma differentiation-associated gene 5) positive dermatomyositis is a new variant of clinically amyopathic dermatomyositis that presents with characteristic mucocutaneous findings and is associated with a higher risk of developing rapidly progressive interstitial lung disease. Because its presentation differs from that of classical dermatomyositis, this entity can be a diagnostic challenge for the clinician.

Methods & Results: We present the case of a 55-year-old male with a 7-month history of chill sensation, constitutional symptoms and polyarthralgia.

Tofacitinib and other kinase inhibitors in the treatment of psoriasis.

Protein kinases play a crucial role in the intracellular signaling pathways involved in inflammation and cell proliferation. Advances in our understanding of these metabolic pathways and of the role played by intracellular signaling in the pathogenesis of psoriasis have led to research in this area and the development of a new class of drugs for the treatment of psoriasis and other inflammatory processes. Since kinase inhibitors are small molecules, oral and topical treatments are possible.

Dermoscopic patterns of melanoma metastases: interobserver consistency and accuracy for metastasis recognition.

Background: Cutaneous metastases of malignant melanoma (CMMM) can be confused with other skin lesions. Dermoscopy could be helpful in the differential diagnosis.

Objectives: To describe distinctive dermoscopic patterns that are reproducible and accurate in the identification of CMMM.