Publications by authors named "Ortiz-Alvarez J"

Introduction: Myroides is a bacterial genus of opportunistic bacteria responsible for diverse infections including in the skin and soft tissues, urinary tract, cardiovascular system, and bacteremia, although the incidence of its reported infections is low, it is increasing, likely due the use of better bacterial identification methods, but also perhaps due an increase in its prevalence. In addition, their pathogenic role is limited in terms of reporting their microbial physiology, so the present work provides information in this regard in addition to the information that is available in the international literature.

Objective: To describe the microbiological and genetic characteristics of seven different Myroides spp.

View Article and Find Full Text PDF

is a native perennial plant used in traditional Mexican medicine. In June 2022, leaf blight symptoms were observed in a wild population of plants. Disease incidence was 80% and disease intensity reached up to 5% of the leaf area.

View Article and Find Full Text PDF

Acinetobacter baumannii belongs to the ESKAPE group. It is classified as a critical priority group by the World Health Organization and a global concern on account of its capacity to acquire and develop resistance mechanisms to multiple antibiotics. Data from the United States indicates 500 deaths annually.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the timing of initiating biological therapy (secukinumab) for managing hidradenitis suppurativa (HS) to improve patient outcomes.
  • It involves a retrospective analysis of 67 patients who switched to secukinumab after failing previous treatments, with follow-up lasting 24 weeks to evaluate safety and effectiveness.
  • Results indicate that 41.79% achieved significant improvement, and a lower therapeutic burden (fewer prior treatments) was linked to better responses, supporting the idea that earlier treatment may be beneficial.
View Article and Find Full Text PDF

Background: Infections caused by Stenotrophomonas maltophilia and related species are increasing worldwide. Unfortunately, treatment options are limited, whereas the antimicrobial resistance is increasing.

Methods: We included clinical isolates identified as S.

View Article and Find Full Text PDF
Article Synopsis
  • - Biological therapy, specifically brodalumab, shows promise in treating hidradenitis suppurativa (HS) by targeting the IL-17 receptor, which may play a role in the disorder's immune dysregulation.
  • - A study involving 16 adults with moderate to severe HS found that 50% achieved an improvement in symptoms and experienced a significant decrease in disease severity after 16 weeks of brodalumab treatment.
  • - The treatment was generally safe, with some patients experiencing mild adverse effects, suggesting that brodalumab is a viable option for those who did not respond to previous biologics like adalimumab.
View Article and Find Full Text PDF

The genomes of species belonging to the genus Colletotrichum harbor a substantial number of cytochrome P450 monooxygenases (CYPs) encoded by a broad diversity of gene families. However, the biological role of their CYP complement (CYPome) has not been elucidated. Here, we investigated the putative evolutionary scenarios that occurred during the evolution of the CYPome belonging to the Colletotrichum Graminicola species complex (s.

View Article and Find Full Text PDF

Sexually transmitted infections are communicable diseases where the pathogen is transmitted through sexual contact. The Sexually Transmitted Infections Working Group of the Spanish Academy of Dermatology and Venereology (AEDV) is engaged in the drafting of documents to guide dermatologists and health care personnel who treat Spanish patients with these infections. This document analyzes the epidemiological, clinical, therapeutic, and control characteristics of 2 sexually transmitted parasitosis: scabies due to Sarcoptes scabiei var.

View Article and Find Full Text PDF

The increasing number of infections caused by antimicrobial multi-resistant microorganisms has led to the search for new microorganisms capable of producing novel antibiotics. This work proposes sp. nov.

View Article and Find Full Text PDF
Article Synopsis
  • - Oculocutaneous albinism (OCA) is a genetic disorder affecting melanin production, studied in pediatric patients through dermatological and ophthalmological exams, including advanced imaging techniques like OCT.
  • - The study found that individuals with a single pathogenic mutation showed milder symptoms, while more severe cases were linked to a greater number of genetic mutations and polymorphisms.
  • - A common observation across all OCA subgroups was paler dermoscopic patterns, particularly varied vascular patterns, which indicated more severe presentations of the disease.
View Article and Find Full Text PDF
Article Synopsis
  • * Researchers isolated various Bacillus strains from mine tailings in Zacatecas, Mexico, which can tolerate heavy metals and enhance soil quality by producing beneficial compounds like siderophores and IAA, and by solubilizing phosphates.
  • * The adaptations found in these Bacillus species, including specific genes for nutrient fixation and toxicity resistance, suggest they play a crucial role in helping ecosystems recover from mining impacts and could aid in phytoremediation efforts.
View Article and Find Full Text PDF
Article Synopsis
  • The study aims to leverage deep transfer learning algorithms to distinguish between in situ melanoma and invasive melanoma, including their Breslow thickness classifications.
  • A dataset of 1,315 dermoscopic images was analyzed using three advanced CNN models (ResNetV2, EfficientNetB6, and InceptionV3), with results indicating EfficientNetB6 had the highest accuracy in diagnosis.
  • The findings suggest that DTL models can effectively aid dermatologists in melanoma classification, potentially enhancing decision-making processes in clinical settings.
View Article and Find Full Text PDF

Background: Ultraviolet radiation is the main environmental risk factor responsible for the development of skin cancer. Other occupational, socioeconomic, and environmental factors appear to be related to the risk of skin cancer. Furthermore, the factors appear to differ for melanoma and non-melanoma skin cancer (NMSC).

View Article and Find Full Text PDF

Background: Digital strategies are innovative approaches to the prevention of skin cancer, but the attrition following this kind of intervention needs to be analyzed.

Objective: The aim of this paper is to assess the dropouts from studies focused on digital strategies for the prevention of skin cancer.

Methods: We conducted this systematic review with meta-analyses and metaregression according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statements.

View Article and Find Full Text PDF

Infantile hemangiomas occur in 3 to 10% of infants. To predict the clinical course and counsel on treatment, it is crucial to accurately determine the hemangiomas' extension, volume, and location. However, this can represent a challenge because hemangiomas may present irregular patterns or be covered by hair, or their depth may be difficult to estimate.

View Article and Find Full Text PDF

Magnusiomyces capitatus (also denominated “Geotrichum capitatum” and “the teleomorph stage of Saprochaete capitata”) mainly affects immunocompromised patients with hematological malignancies in rare cases of invasive fungal infections (IFIs). Few cases have been reported for pediatric patients with acute lymphoblastic leukemia (ALL), in part because conventional diagnostic methods do not consistently detect M. capitatus in infections.

View Article and Find Full Text PDF

Down syndrome (DS) has been related to a higher risk of hidradenitis suppurativa (HS). This cross-sectional study assessed DS patients with HS in a Spanish single-centre sample. DS participants presented a lower age of onset, age at diagnosis and time to diagnosis.

View Article and Find Full Text PDF

Due to the emergence of multidrug-resistant strains of yeasts belonging to the Candida genus, there is an urgent need to discover antifungal agents directed at alternative molecular targets. The aim of the current study was to evaluate the capacity of three different series of synthetic compounds to inhibit the Candida glabrata enzyme denominated 3-hydroxy-methyl-glutaryl-CoA reductase and thus affect ergosterol synthesis and yeast viability. Compounds 1c (α-asarone-related) and 5b (with a pyrrolic core) were selected as the best antifungal candidates among over 20 synthetic compounds studied.

View Article and Find Full Text PDF

Non-melanoma skin cancers (NMSC) are the most common malignancies worldwide and are, worryingly, increasing in incidence. However, data in the literature on NMSC specific mortality are scarce, because these tumors are excluded from most mortality registries. The main objective of this study is to analyze NMSC's mortality rates and use them to generate a predictive model for the coming years in Spain.

View Article and Find Full Text PDF

Unlabelled: Dermal fillers are applied using a minimally invasive technique with a good safety profile. However, they can have side effects. We present the case of a patient who, 2 months after undergoing polycaprolactone (Ellansé) injections, developed nodular facial and nodal lesions that were compatible with sarcoidosis on histology.

View Article and Find Full Text PDF

Background: Vascular malformations are a complex pathology with few treatment options. In previously published studies, oral sirolimus (rapamycin) has shown promising results in the treatment of low-flow vascular malformations, but its usefulness in high-flow vascular malformations is controversial.

Aim: To evaluate the efficacy and safety of sirolimus for the treatment of high-flow vascular malformations in real-life practice.

View Article and Find Full Text PDF